Differential activation of the human costal and crural diaphragm during voluntary and involuntary breaths

2020 ◽  
Vol 128 (5) ◽  
pp. 1262-1270 ◽  
Author(s):  
D. A. T. Nguyen ◽  
N. Amirjani ◽  
E. J. McCaughey ◽  
S. C. Gandevia ◽  
J. E. Butler ◽  
...  
Keyword(s):  
Tidal Breathing ◽  
Differential Activation ◽  
Crural Diaphragm ◽  
Diaphragm Activity

Simultaneous electromyographic recordings from the human costal and crural diaphragm during voluntary augmented breathing and involuntary rebreathing show that the increase in inspiratory crural diaphragm activity was ~60% of the increase in costal diaphragm activity. However costal to crural diaphragm activation did not differ between the two tasks. The dissociation in the amplitude of activation of the costal and crural diaphragm becomes apparent only as the drive to breathe increases above tidal breathing.

Effects of CO2 and bronchoconstriction on costal and crural diaphragm electromyograms

1984 ◽  
Vol 57 (5) ◽  
pp. 1347-1353 ◽  
Author(s):  
E. van Lunteren ◽  
M. A. Haxhiu ◽  
E. C. Deal ◽  
D. Perkins ◽  
N. S. Cherniack
Keyword(s):  
Electrical Activity ◽  
Neural Control ◽  
Maximal Increase ◽  
Diaphragm Electrical Activity ◽  
Anesthetized Dogs ◽  
Relative Delay ◽  
Inspiratory Activity ◽  
Crural Diaphragm ◽  
Diaphragm Activity ◽  
Irregular Breathing

To determine if neural control of the crural diaphragm is similar to that of the costal diaphragm, electrical activity was recorded from these two parts of the diaphragm in 10 anesthetized dogs during resting O2 breathing and during progressive hyperoxic hypercapnia. Within a breath, the onset of crural diaphragm inspiratory activity started significantly earlier than that of the costal diaphragm under both resting and CO2 stimulated conditions, although the relative delay in costal diaphragm activity was smaller during hypercapnia than during resting O2 breathing. Following hyperventilation to apnea, both parts of the diaphragm resumed activity on the same breath. During CO2 rebreathing, the maximal increase in crural diaphragm peak electrical activity was significantly greater than that of the costal diaphragm. We also examined the effects of histamine-induced bronchoconstriction on diaphragm activity. Following administration of histamine aerosol there was a transient of irregular breathing during which in three animals costal diaphragm activity became nearly quiet, although there was continued activity of the crural diaphragm. Once breathing became more regular, there was a significantly greater stimulation of crural diaphragm than costal diaphragm activity; this difference persisted for 15 min after histamine inhalation. These results support the concept that electrical activity can be distributed nonuniformly to the costal and crural diaphragm and demonstrate that the crural diaphragm has a greater gain with hypercapnia and bronchoconstriction than does the costal diaphragm.

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