Adaptation of Mitochondrial Gene Expression to Changing Cellular Energy Demands

Physiology ◽  
1997 ◽  
Vol 12 (4) ◽  
pp. 178-184 ◽  
Author(s):  
RJ Wiesner
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Energy Demand ◽  
Feedback Loop ◽  
Mitochondrial Gene ◽  
Negative Feedback Loop ◽  
Mitochondrial Gene Expression ◽  
Demand And Supply ◽  
Cellular Energy ◽  
Energy Demands

Training of skeletal muscle, as well as thyroid and steroid hormones, stimulates mitochondrial biogenesis, which requires regulation of genes encoded on nuclear and mitochondrial DNA. Imbalances between energy demand and supply increase mitochondrial gene expression via as yet unknown metabolic signals involving transcription factors in the sense of a negative feedback loop.

scholarly journals Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle.

1986 ◽  
Vol 261 (1) ◽  
pp. 376-380 ◽  
Author(s):  
R S Williams ◽  
S Salmons ◽  
E A Newsholme ◽  
R E Kaufman ◽  
J Mellor
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Contractile Activity ◽  
Mitochondrial Gene ◽  
Mitochondrial Gene Expression

scholarly journals The dynamics of mitochondrial-linked gene expression among tissues and life stages in two contrasting strains of laying hens

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262613
Author(s):  
Clara Dreyling ◽  
Martin Hasselmann
Keyword(s):  
Gene Expression ◽  
Energy Metabolism ◽  
Life Span ◽  
Laying Hens ◽  
Mitochondrial Gene ◽  
Model Organisms ◽  
Life Stages ◽  
Mitochondrial Gene Expression ◽  
Cellular Energy ◽  
Cellular Energy Metabolism

The cellular energy metabolism is one of the most conserved processes, as it is present in all living organisms. Mitochondria are providing the eukaryotic cell with energy and thus their genome and gene expression has been of broad interest for a long time. Mitochondrial gene expression changes under different conditions and is regulated by genes encoded in the nucleus of the cell. In this context, little is known about non-model organisms and we provide the first large-scaled gene expression analysis of mitochondrial-linked genes in laying hens. We analysed 28 mitochondrial and nuclear genes in 100 individuals in the context of five life-stages and strain differences among five tissues. Our study showed that mitochondrial gene expression increases during the productive life span, and reacts tissue and strain specific. In addition, the strains react different to potential increased oxidative stress, resulting from the increase in mitochondrial gene expression. The results suggest that the cellular energy metabolism as part of a complex regulatory system is strongly affected by the productive life span in laying hens and thus partly comparable to model organisms. This study provides a starting point for further analyses in this field on non-model organisms, especially in laying-hens.

scholarly journals Regulation of mitochondrial gene expression by energy demand in neural cells

2005 ◽  
Vol 93 (4) ◽  
pp. 850-860 ◽  
Author(s):  
Zara Mehrabian ◽  
Li-Ing Liu ◽  
Gary Fiskum ◽  
Stanley I. Rapoport ◽  
Krish Chandrasekaran
Keyword(s):  
Gene Expression ◽  
Energy Demand ◽  
Mitochondrial Gene ◽  
Neural Cells ◽  
Mitochondrial Gene Expression

scholarly journals Chronically endurance-trained individuals preserve skeletal muscle mitochondrial gene expression with age but differences within age groups remain

2014 ◽  
Vol 2 (12) ◽  
pp. e12239 ◽  
Author(s):  
Matthew L. Johnson ◽  
Ian R. Lanza ◽  
Daniel K. Short ◽  
Yan W. Asmann ◽  
K. Sreekumaran Nair
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Mitochondrial Gene ◽  
Age Groups ◽  
Mitochondrial Gene Expression

A mitochondrial Pac-man drug to tackle aging

2019 ◽  
Vol 11 (501) ◽  
pp. eaay3574
Author(s):  
Ming Yang
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Mitochondrial Gene ◽  
Mitochondrial Gene Expression ◽  
Elderly Individuals ◽  
Urolithin A

Urolithin A, an activator of mitophagy, is safe to use and increases skeletal muscle mitochondrial gene expression in elderly individuals.

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