scholarly journals NSAIDs in the Treatment of Adult Asthma: Sodium Cromoglycate and Nedocromil Sodium

1995 ◽  
Vol 2 (suppl a) ◽  
pp. 19A-23A ◽  
Author(s):  
Michel-Y Rouleau
Keyword(s):  
Sodium Cromoglycate ◽  
Low Dose ◽  
Similar Efficacy ◽  
Nedocromil Sodium ◽  
Mild Asthma ◽  
Adult Asthma ◽  
Inhaled Steroids ◽  
Inflammatory Drugs ◽  
Efficacy Profile ◽  
Steroid Sparing

Among nonsteroidal anti-inflammatory drugs used in the treatment of adult asthma, sodium cromoglycate and nedocromil sodium are the most frequently prescribed. These medications have a similar efficacy profile in asthma although it has been suggested that nedocromil is more powerful than cromoglycate, particularly in its steroid sparing effects. Both drugs have been recommended as alternatives to steroids in the treatment of mild asthma. They are useful in the prevention of bronchospasm induced by exposure to allergens or to a variety of other stimuli. In comparison with theophylline or low dose inhaled steroids, cromoglycate and nedocromil have shown a similar antiasthmatic efficacy, although this is variable among patients.

▾Nedocromil aerosol in adult asthma

1988 ◽  
Vol 26 (24) ◽  
pp. 95-96
Keyword(s):  
Sodium Cromoglycate ◽  
Maintenance Treatment ◽  
Nedocromil Sodium ◽  
First Line ◽  
Adult Asthma

Nedocromil sodium (Tilade - Fisons) aims to improve on the same company’s sodium cromoglycate (Intal), now 20 years old. The drug is promoted as “a first-line maintenance treatment for adults” with asthma.

scholarly journals Clinical equivalency of Beclasone Eco Easi Breathe and Flixotide via MDI in asthma patients

2007 ◽  
pp. 74-81
Author(s):  
A. A. Visel ◽  
V. N. Seliverstov ◽  
I. Yu. Visel ◽  
V. A. Sergeev ◽  
N. M. Rakhmatullina
Keyword(s):  
Severe Asthma ◽  
Comparative Trial ◽  
Similar Efficacy ◽  
Heart Beat ◽  
Inhaled Steroids ◽  
Russian Version ◽  
Asthma Patients ◽  
Heart Beat Rate ◽  
Physical Findings

It is well known that efficacy of asthma treatment depends on a choice of a basic medication as well as on a delivery system. The aim of this study was a comparison of clinical efficacy of equal doses of beclomethasone dipropionate (Beclasone Eco Easi Breathe) and fluticasone propionate (Flixotide) via MDI. The study was designed as a randomized open prospective comparative trial. Findings of 26 patients with moderate and severe asthma of > 18 yrs old were analyzed, such as medical history, physical findings, spirometric and bronchodilating test results, heart beat rate and blood pressure, quality of life (QoL) using Russian version of AQLQ questionnaire. After the run-in period the patients randomly received Beclasone Eco Easi Breathe 500 to 1000 μg daily or Flixotide at the same doses for 4 weeks followed the cross-over change of the drugs for the next 4 weeks. After 1 month of the treatment, significant improvements in airflow parameters, need in short-acting β2 -agonists and QoL have been reported. After changing the drugs these effects have been maintained with no further reliable improvement. Thus, the study demonstrated similar efficacy and safety of these inhaled steroids that could be considered as being clinically equal in treatment of moderate and severe asthma.

Low-dose budesonide beneficial in mild asthma

2003 ◽  
Vol &NA; (1381) ◽  
pp. 14
Author(s):  
&NA;
Keyword(s):  
Low Dose ◽  
Mild Asthma

Case Report: Rapid Response to Low-Dose Thalidomide in a Case of Severe Steroid Recalcitrant Erythema Nodosum Leprosum

2021 ◽  
Author(s):  
B. Savitha ◽  
Kabir Sardana ◽  
Ritu Kumari ◽  
Ananta Khurana ◽  
Surabhi Sinha ◽  
...  
Keyword(s):  
Low Dose ◽  
Erythema Nodosum ◽  
Lepromatous Leprosy ◽  
High Dose ◽  
Effective Treatment Option ◽  
Steroid Dependence ◽  
Erythema Nodosum Leprosum ◽  
Organ Specific ◽  
Inflammatory Drugs

Erythema nodosum leprosum (ENL), or type 2 lepra reaction, presents with crops of evanescent, tender erythematous nodules accompanied by fever, arthralgia, weight loss, malaise, and organ-specific manifestations, and is seen in borderline and lepromatous leprosy. The drugs approved for ENL include nonsteroidal anti-inflammatory drugs, systemic steroids, thalidomide, and clofazimine. The management of ENL is challenging because long-term steroid use leads to steroid dependence. Our patient had severe steroid recalcitrant ENL with vesicular and pustular lesions mimicking Sweet’s syndrome, and was treated effectively with a low-dose thalidomide regimen (100 mg/d) as opposed to the high dose (400 mg/d) recommended in the literature. We discuss the patho-mechanics and clinical utility of a low-dose thalidomide regimen as an effective treatment option for ENL.

scholarly journals Reduction of Eosinophils in Small Airways by Inhaled Steroids is Insufficient in Patients with Adult Asthma

2006 ◽  
Vol 55 (3) ◽  
pp. 305-309 ◽  
Author(s):  
Hiroshi Tanaka ◽  
Midori Hashimoto ◽  
Masaru Fujii ◽  
Nobuyuki Tanaka ◽  
Kazuhiko Suzuki ◽  
...  
Keyword(s):  
Small Airways ◽  
Adult Asthma ◽  
Inhaled Steroids
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