scholarly journals NSAID Gastroenteropathy: Past, Present and Future

1996 ◽  
Vol 10 (7) ◽  
pp. 451-459 ◽  
Author(s):  
John L Wallace
Keyword(s):  
Gastrointestinal Tract ◽  
Inflammatory Disorders ◽  
The Past ◽  
Prostaglandin Synthase ◽  
Nsaid Enteropathy ◽  
The Future ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Identification And Characterization

The toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) in the gastrointestinal tract continues to be a major limitation to their use in the treatment of inflammatory disorders. Better understanding of the pathogenesis of NSAID enteropathy has facilitated the development of novel NSAIDs that spare the gastrointestinal tract. In particular, identification and characterization of the inducible form of prostaglandin synthase has led to the design of novel NSAIDs that specifically target that enzyme. The pathogenesis of NSAID gastroenteropathy is reviewed, as are the strategies that have been used in the past and are used now to develop NSAIDs that spare the gastrointestinal tract. Also reviewed are the strategies being employed to achieve this goal in the future.

scholarly journals Porcelain enamel coatings, from the past to the future: solved and unsolved issues for the improvement of their mechanical properties.

2020 ◽  
Author(s):  
Stefano Rossi ◽  
Francesca Russo
Keyword(s):  
Mechanical Properties ◽  
Industrial Revolution ◽  
Chemical Degradation ◽  
Protective Properties ◽  
The Past ◽  
Enhanced Resistance ◽  
Mechanical Study ◽  
The Future ◽  
Ancient Times

Porcelain enamel coatings have their origins in ancient times when they were mainly used for decorative and ornamental purposes. From the industrial revolution onwards, these coatings have started to be used also as functional layers, ranging from home applications up to the use in high-technological fields, such as in chemical reactors. The excellent properties of enamel coatings, such as fire resistance, protection of the substrate from corrosion, resistance to atmospheric and chemical degradation, mainly depend and originate from the glassy nature of the enamel matrix itself. On the other side, the vitreous nature of enamel coatings limits their application in many fields, where mechanical stress and heavy abrasion phenomena could lead to nucleation and propagation of cracks inside the material, thus negatively affecting the protective properties of this coating. Many efforts have been made to improve the abrasion resistance of enamelled materials. On this regard, researchers showed encouraging results and proposed many different improvement approaches. Now it is possible to obtain enamels with enhanced resistance to abrasion. Differently, the investigation of the mechanical properties of enamel coatings remains a poorly studied topic. In the literature, there are interesting methodological ideas, which could be successfully applied to the mechanical study of enamelled materials and could allow to have further insights on their behaviour. Thus, the path that should be followed in the future includes the mechanical characterization of these coatings and the search for new solutions to address their brittle behaviour.

scholarly journals Characterization of subjects experiencing selective hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs)

2019 ◽  
Vol 143 (2) ◽  
pp. AB29
Author(s):  
Natalia Pérez-Sánchez ◽  
Inmaculada Doña ◽  
Maria Salas ◽  
Testera-Montes Almudena ◽  
Francisca Gomez ◽  
...  
Keyword(s):  
Hypersensitivity Reactions ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Autonomy and the Perspectives of Its Artificial Implementation

Proceedings ◽  
2020 ◽  
Vol 47 (1) ◽  
pp. 34
Author(s):  
Marcin J. Schroeder
Keyword(s):  
Free Choice ◽  
The Past ◽  
The Future ◽  
External Causes ◽  
Definition Of

Whichever definition of autonomy is used, it is usually formulated in a negative way by the absence, rather than presence, of the defining factors. Some definitions refer to the absence of external causes, physical determination, coercion or control. If positive factors are used, autonomy is associated with the shift from effective causes to final ones. Both approaches, the former of which is based on the elimination of determinism to secure free choice, and the latter of which is based on the replacement of determination by the past by determination by the future, are inconsistent with the scientific description of reality. This paper is an attempt to provide the positive, constructive characterization of autonomy consistent with the scientific view of reality, which can guide us in our search for its implementation in artefacts.

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