scholarly journals A Simple, Sensitive Spectrophotometric Determination of Mosapride in Pharmaceutical Preparations Using Novel Reagent

2004 ◽  
Vol 1 (5) ◽  
pp. 267-271 ◽  
Author(s):  
G. Krishnamurthy Naidu ◽  
K. Suvardhan ◽  
M. V. Jyothi ◽  
B. S. Sastry ◽  
P. Chiranjeevi
Keyword(s):  
Optimum Condition ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Azo Dye ◽  
Acidic Medium ◽  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Pharmaceutical Formulation ◽  
Sensitive Spectrophotometric Method

A rapid, selective and sensitive spectrophotometric method for the determination of mosarpide in either pure form or in its formulations in pharmaceutical preparations is described. The method is based on the diazotization coupling reaction of mosapride with 1-naphthol in acidic medium to give red azo dye product with theλmaxof 500 nm and is stable for more than 12 hours at optimum condition, Beer's law is obeyed at concentration of 0.2 to 12 μg mL-1at the wavelength of maximum absorbance. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed method. The developed method is highly reproducible and applied to wide variety of pharmaceutical formulation and the results were compared favourably with the reported method.

scholarly journals Spectrophotometric Determination of Epinephrine in Pharmaceutical Preparations Using Praseodymium as Mediating Metals

2011 ◽  
Vol 8 (1) ◽  
pp. 110-117 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Relative Error ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Direct Methods ◽  
Orange Yellow ◽  
Sensitive Spectrophotometric Method

A simple, accurate and sensitive spectrophotometric method for the determinaion of epinephrine is described . The method is based on the coordination of Pr (III) with epinephrine at pH 6. Absorbance of the resulting orange yellow complex is measured at 482 nm . A graph of absorbance versus concentrations shows that beer 's low is obeyed over the concentration range (1-50)mg.ml-1 of epinephrine with molar absorpitivity of ( 2.180x103 L.mol-1.cm-1 ), a sandell sensitivity of (0.084 mg.cm-2 ), a relative error of (-2.83%) , a corrolation coffecient (r= 0.9989) and recovery % ( 97.03 ± 0.75 ) depending on the concentration.This method is applied to analyse EP in several commercially available pharmaceutical preparations using direct methods .All statistical calculations are implemented via a Minitab software version 11.

scholarly journals Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–Chlorimide

2007 ◽  
Vol 4 (1) ◽  
pp. 50-52 ◽  
Author(s):  
M. Vamsi Krishna ◽  
P. V. Madhavi Latha ◽  
D. Gowri Sankar
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Oxidative Coupling ◽  
Pharmaceutical Preparations ◽  
Coupling Product ◽  
Beer's Law ◽  
Beer’S Law ◽  
Sensitive Spectrophotometric Method

A simple, sensitive spectrophotometric method for the determination of Famciclovir and Racecodotril is developed. It is based on the formation of a colored oxidative coupling product between 2,6-dichloroquinone-chlorimide and the drug is described. The method has been extended to pharmaceutical preparations. The absorption maxima and Beer’s law limits for Famciclovir are 500 nm, 20-100 µg/mL and for Racecodotril are 460 nm, 12.5-62.5 µg/mL.

scholarly journals Spectrophotometric Determination of Paracetamol in bulk and Pharmaceutical Preparations

2015 ◽  
Vol 12 (2) ◽  
pp. 317-323
Author(s):  
Baghdad Science Journal
Keyword(s):  
Sodium Hydroxide ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Reaction Conditions ◽  
Accuracy And Precision ◽  
Beer's Law ◽  
Beer’S Law

A simple, and rapid spectrophotometric method for the estimation of paracetamol has been developed. The methods is based on diazotisation of 2,4-dichloroaniline followed by a coupling reaction with paracetamol in sodium hydroxide medium. All variables affecting the reaction conditions were carefully studied. Beer's law is obeyed in the concentration range of 4-350 ?gml?1 at 490 nm .The method is successfully employed for the determination of paracetamol in pharmaceutical preparations. No interferes observed in the proposed method. Analytical parameters such as accuracy and precision have been established for the method and evaluated statistically to assess the application of the method.

scholarly journals Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations

2009 ◽  
Vol 6 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Alka Gupta ◽  
P. Mishra ◽  
K. Shah
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Pure Form ◽  
Ultraviolet Region ◽  
Rosuvastatin Calcium ◽  
Sensitive Spectrophotometric Method

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of rosuvastatin calcium in bulk and in pharmaceutical formulations. Rosuvastatin exhibits absorption maxima at 244 nm with apparent molar absorptivity of 7.2345 ×104L/mol.cm in methanol. Beer’s law was found to be obeyed in the concentration range of 2-18 µg/mL. The method is accurate, precise and economical. This method is extended to pharmaceutical preparations. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studies

scholarly journals SPECTROPHTOTOMETRIC DETERMINATION OF PURE SULFAMETHOXAZOLE IN PHARMACEUTICAL PREPARATIONS BY OXIDATIVE COUPLING REACTION

2021 ◽  
Vol 13 (1) ◽  
pp. 65-76
Author(s):  
Noor M. Ghaib Allah1 ◽  
Keyword(s):  
Correlation Coefficient ◽  
Spectrophotometric Method ◽  
Oxidative Coupling ◽  
Sulfonic Acid ◽  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Potassium Iodate ◽  
Oxidative Coupling Reaction ◽  
Sensitive Spectrophotometric Method

A new, simple, rapid and sensitive spectrophotometric method for the determination of sulfamethoxazole in both pure form and pharmaceutical preparations has been reported.The adapted technique based on utilization 4-aminobenzene sulfonic acid as a new modern chromogenic through an oxidative coupling reaction with sulfamethoxazole and potassium iodate in basic media to form orange soluble dye product with absorption maxima at 490 nm. Subject to Beer's law in the range 2–32μg mL-1. The values of molarabsorption coefficient (ε) and correlation coefficient were found to be 9.118 × 103 and0.9999 respectively whereas the Sandels index was 0. 02778 µg.cm-2

A new optical sensor for spectrophotometric determination of uranium (VI) and thorium (IV) in acidic medium

2017 ◽  
Vol 105 (12) ◽  
Author(s):  
O. A. Elhefnawy
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Optical Sensor ◽  
Acidic Medium ◽  
Complexation Reaction

AbstractA spectrophotometric method was developed for U(VI) and Th(IV) determination in acidic medium by using proposed optical sensor. This sensor is base on the complexation reaction of the ionophore midodrine hydrochloride (

scholarly journals Spectrophotometric Determination ofN-Acetyl-L-Cysteine andN-(2-Mercaptopropionyl)-Glycine in Pharmaceutical Preparations

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Lea Kukoc-Modun ◽  
Njegomir Radić
Keyword(s):  
Regression Analysis ◽  
Detection Limit ◽  
Correlation Coefficient ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Complexation Reaction ◽  
Calibration Data ◽  
Pharmaceutical Excipients

A simple spectrophotometric method for the determination ofN-acetyl-L-cysteine (NAC) andN-(2-mercaptopropionyl)glycine (MPG) in pharmaceutical preparations was developed, validated, and used. The proposed equilibrium method is based on a coupled two-step redox and complexation reaction. In the first step, Fe(III) is reduced to Fe(II) by NAC or MPG. Subsequently, Fe(II) is complexed with 2,4,6-tripyridyl-s-triazine (TPTZ). Several analytical parameters of the method were optimized for NAC and MPG analysis in the concentration range from 1.0 μM to 100.0 μM. Regression analysis of the calibration data showed a good correlation coefficient (0.9999). The detection limit of the method was 0.14 μM for NAC and 0.13 μM for MPG. The method was successfully applied to quantify NAC and MPG in pharmaceutical preparations. No interferences were observed from common pharmaceutical excipients.

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