Brachytherapy for Prostate Cancer: A Systematic Review

Low-dose rate brachytherapy has become a mainstream treatment option for men diagnosed with prostate cancer because of excellent long-term treatment outcomes in low-, intermediate-, and high-risk patients. To a great extend due to patient lead advocacy for minimally invasive treatment options, high-quality prostate implants have become widely available in the US, Europe, and Japan. High-dose-rate (HDR) afterloading brachytherapy in the management of localised prostate cancer has practical, physical, and biological advantages over low-dose-rate seed brachytherapy. There are no free live sources used, no risk of source loss, and since the implant is a temporary procedure following discharge no issues with regard to radioprotection use of existing facilities exist. Patients with localized prostate cancer may benefit from high-dose-rate brachytherapy, which may be used alone in certain circumstances or in combination with external-beam radiotherapy in other settings. The purpose of this paper is to present the essentials of brachytherapies techniques along with the most important studies that support their effectiveness in the treatment of prostate cancer.

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High-dose-rate brachytherapy monotherapy versus low-dose-rate brachytherapy with or without external beam radiotherapy for clinically localized prostate cancer

Radiotherapy and Oncology ◽

10.1016/j.radonc.2018.10.020 ◽

2019 ◽

Vol 132 ◽

pp. 162-170 ◽

Cited By ~ 7

Author(s):

Hideya Yamazaki ◽

Koji Masui ◽

Gen Suzuki ◽

Satoaki Nakamura ◽

Kei Yamada ◽

...

Keyword(s):

Prostate Cancer ◽

Dose Rate ◽

Low Dose ◽

External Beam Radiotherapy ◽

High Dose Rate ◽

Localized Prostate Cancer ◽

High Dose ◽

External Beam ◽

Low Dose Rate ◽

Low Dose Rate Brachytherapy

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A comparison of outcomes for patients with intermediate and high risk prostate cancer treated with low dose rate and high dose rate brachytherapy in combination with external beam radiotherapy

Clinical and Translational Radiation Oncology ◽

10.1016/j.ctro.2019.10.001 ◽

2020 ◽

Vol 20 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

Finbar Slevin ◽

Sree Lakshmi Rodda ◽

Peter Bownes ◽

Louise Murray ◽

David Bottomley ◽

...

Keyword(s):

Prostate Cancer ◽

Dose Rate ◽

Low Dose ◽

External Beam Radiotherapy ◽

High Dose Rate ◽

High Dose ◽

External Beam ◽

Low Dose Rate ◽

High Risk Prostate Cancer ◽

Risk Prostate Cancer

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LOW-DOSE-RATE OR HIGH-DOSE-RATE BRACHYTHERAPY IN COMBINATION WITH EXTERNAL BEAM RADIOTHERAPY FOR INTERMEDIATE AND HIGH-RISK PROSTATE CANCER

Problems in oncology ◽

10.37469/0507-3758-2018-64-1-79-83 ◽

2018 ◽

Vol 64 (1) ◽

pp. 79-83

Author(s):

Vladimir Solodkiy ◽

Andrey Pavlov ◽

Aleksey Tsybulskiy ◽

Anton Ivashin

Keyword(s):

Prostate Cancer ◽

High Risk ◽

Dose Rate ◽

Low Dose ◽

External Beam Radiotherapy ◽

Combined Treatment ◽

High Dose ◽

External Beam ◽

Low Dose Rate ◽

Risk Of Progression

Introduction. One of the main problems of modem on-courology is treatment for prostate cancer of intermediate and high risk of progression. Modern radiotherapy in this category of patients has an advantage over surgical methods of treatment. One way to improve the effectiveness of radiotherapy is to escalate the dose in the prostate gland. For this purpose a combination of brachytherapy and remote radiotherapy is used. This combination allows increasing the dose of radiation, thereby providing better local control, reducing complications from neighboring organs. Purpose of the study. To conduct a comparative analysis of efficacy and safety of radical treatment of patients with prostate cancer at medium and high risk of progression using a combination of high and low dose rate brachytherapy with external beam radiotherapy. Materials and methods. 107 patients with prostate cancer of the group of medium and high risk of progression combined treatment (brachytherapy with external beam radiotherapy) was conducted. 53 patients underwent combined treatment (HDR-brachytherapy and external beam radiotherapy). 54 patients underwent combined treatment (LDR-brachytherapy and external beam radiotherapy). The observation period was 5 years. Conclusion. In a comparative analysis in groups of combined radiotherapy with the use of high-dose and low-dose-rate brachytherapy, the same effectiveness of immediate and long-term results of treatment was demonstrated. A significant reduction in early and late toxic reactions in patients with high-power brachytherapy has been demonstrated.

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