The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity
2010 ◽
Vol 2010
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pp. 1-6
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Keyword(s):
IL-2 production is decreased in systemic lupus erythematosus (SLE) patients and affects T cell function and other aspects of host immunity. Transcription factors regulating IL-2 production behave aberrantly in SLE T cells. In addition to IL-2 dysregulation, other IL-2 family members (IL-15 and IL-21) are abnormally expressed in SLE. Decreased IL-2 production in SLE patients leads to many immune defects such as decreasedTregproduction, decreased activation-induced cell death (AICD), and decreased cytotoxicity. IL-2 deficiency results in systemic dysregulation of host immune responses in patients suffering from SLE disease.
9 THE GENES, ENVIRONMENT, AND HOST IMMUNE RESPONSES IN THE ETIOLOGY OF SYSTEMIC LUPUS ERYTHEMATOSUS.
2004 ◽
Vol 52
(Suppl 1)
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pp. S258.4-S258
2015 ◽
Vol 42
(8)
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pp. 1401-1405
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