scholarly journals Visuo-Spatial Imagery Impairment in Posterior Cortical Atrophy: A Cognitive and SPECT Study

2011 ◽  
Vol 24 (2) ◽  
pp. 123-132 ◽  
Author(s):  
Simona Gardini ◽  
Letizia Concari ◽  
Salvatrice Pagliara ◽  
Caterina Ghetti ◽  
Annalena Venneri ◽  
...  
Keyword(s):  
Autobiographical Memory ◽  
Semantic Memory ◽  
Mental Imagery ◽  
Spatial Representation ◽  
Right Hemisphere ◽  
Cortical Atrophy ◽  
Precentral Gyrus ◽  
Posterior Cortical Atrophy ◽  
Spatial Imagery ◽  
Topographical Disorientation

This study investigated the cognitive profile and the cerebral perfusion pattern in a highly educated 70 year old gentleman with posterior cortical atrophy (PCA). Visuo-perceptual abilities, spatial memory, spatial representation and navigation, visuo-spatial mental imagery, semantic and episodic-autobiographical memory were assessed. Regional cerebral blood flow (rCBF) was imaged with SPECT. Cognitive testing showed visual-perceptual impairment, apperceptive visual and landmark agnosia, topographical disorientation with way-finding deficits, impaired map learning and poor mental image generation. Semantic memory was normal, while episodic-autobiographical memory was impaired. Reduced rCBF was found mainly in the right hemisphere, in the precentral gyrus, posterior cingulate and middle temporal gyri, cuneus and precuneus, in the left superior temporal and lingual gyri and in the parahippocampus bilaterally. Hypoperfusion in occipito-parietal regions was associated with visuo-spatial deficits, whereas deficits in visuo-spatial mental imagery might reflect dysfunction related to hypoperfusion in the parahippocampus and precuneus, structures which are responsible for spatial and imagery processing. Dissociating performance between preserved semantic memory and poor episodic-autobiographical recall is consistent with a pattern of normal perfusion in frontal and anterior temporal regions but abnormal rCBF in the parahippocampi. The present findings indicate that PCA involves visuo-spatial imagery deficits and provide further validation to current neuro-cognitive models of spatial representation and topographical disorientation.

[P3-270]: VISUAL IMAGERY AND AUTOBIOGRAPHICAL MEMORY IMPAIRMENT IN POSTERIOR CORTICAL ATROPHY

2017 ◽  
Vol 13 (7S_Part_22) ◽  
pp. P1046-P1047
Author(s):  
Samrah Ahmed ◽  
Muireann Irish ◽  
Clare Loane ◽  
Ian Baker ◽  
Masud Husain ◽  
...  
Keyword(s):  
Autobiographical Memory ◽  
Visual Imagery ◽  
Memory Impairment ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

scholarly journals Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome

2018 ◽  
Vol 18 ◽  
pp. 822-834 ◽  
Author(s):  
Samrah Ahmed ◽  
Muireann Irish ◽  
Clare Loane ◽  
Ian Baker ◽  
Masud Husain ◽  
...  
Keyword(s):  
Autobiographical Memory ◽  
Memory Impairment ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

P1-231: Posterior Cortical Atrophy (PCA) and Mental Imagery Deficits

2016 ◽  
Vol 12 ◽  
pp. P496-P496
Author(s):  
Jennifer C. Scuse ◽  
Dina I. Drubach ◽  
Daniel A. Drubach
Keyword(s):  
Mental Imagery ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

THE MAN WHO MISTOOK THE FRIDGE FOR A DOOR: AN ATYPICAL PRESENTATION OF DEMENTIA WITH LEWY BODIES

2015 ◽  
Vol 86 (11) ◽  
pp. e4.141-e4
Author(s):  
Sean O'Dowd ◽  
Tudor Munteanu ◽  
Daniel Hardiman ◽  
Niall Sheehy ◽  
Janice Redmond
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy ◽  
Mathematical Skills ◽  
Visual Symptoms ◽  
Topographical Disorientation ◽  
History Of ◽  
Alzheimer Pathology ◽  
History Of Depression

A 61-year old engineer was referred for a fourth opinion regarding visual symptoms. He had a recent history of depression, and was taking fluoxetine. He reported an eight-year history of progressive visual symptoms, manifest particularly as difficulty judging distances and depth. He acknowledged visual misperceptions and rare visual hallucinations; his reading had deteriorated; he complained of loss of mathematical skills. There had been episodic topographical disorientation. Memory and insight were preserved. There were no extrapyramidal symptoms. Examination (see video) revealed evidence of significant parietal and some frontal dysfunction. Visuospatial and visuoperceptual impairments were particularly marked. There was no evidence of parkinsonism. A diagnosis of posterior cortical atrophy (PCA) syndrome was made. Structural imaging was reported as normal but SPECT imaging revealed bilateral presynaptic dopaminergic denervation and FDG-PET demonstrated significant parieto-occipital hypometabolism. CSF tau and beta-amyloid levels were normal. A diagnosis of probable dementia with Lewy bodies (DLB) was made. PCA is a relatively rare and often under-recognised neurodegenerative syndrome, most frequently associated with Alzheimer pathology. The clinical and paraclinical findings in this case suggest a Lewy body process, which very rarely presents as PCA. The challenges pertaining to the accurate diagnosis of PCA and the implications for management are discussed.

P3-201: Posterior cortical atrophy (PCA) and mental imagery: A pilot study

2015 ◽  
Vol 11 (7S_Part_15) ◽  
pp. P710-P710
Author(s):  
Jennifer C. Scuse ◽  
Dina I. Drubach ◽  
Daniel A. Drubach
Keyword(s):  
Pilot Study ◽  
Mental Imagery ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

Very early-onset posterior cortical atrophy

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
W.G. Janzarik ◽  
S. Rauer ◽  
C. Weiller ◽  
K. Schmidtke
Keyword(s):  
Early Onset ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

scholarly journals Is Lateropulsion Really Related with a Specific Lesion of the Brain?

2021 ◽  
Vol 11 (3) ◽  
pp. 354
Author(s):  
Kyoung Lee ◽  
Sang Yoo ◽  
Eun Ji ◽  
Woo Hwang ◽  
Yeun Yoo ◽  
...  
Keyword(s):  
Right Hemisphere ◽  
Parietal Lobe ◽  
Inferior Frontal Gyrus ◽  
Brain Lesions ◽  
Vertical Posture ◽  
Lesion Volume ◽  
Precentral Gyrus ◽  
Stroke Patients ◽  
The Right ◽  
Right Hemisphere Stroke

Lateropulsion (pusher syndrome) is an important barrier to standing and gait after stroke. Although several studies have attempted to elucidate the relationship between brain lesions and lateropulsion, the effects of specific brain lesions on the development of lateropulsion remain unclear. Thus, the present study investigated the effects of stroke lesion location and size on lateropulsion in right hemisphere stroke patients. The present retrospective cross-sectional observational study assessed 50 right hemisphere stroke patients. Lateropulsion was diagnosed and evaluated using the Scale for Contraversive Pushing (SCP). Voxel-based lesion symptom mapping (VLSM) analysis with 3T-MRI was used to identify the culprit lesion for SCP. We also performed VLSM controlling for lesion volume as a nuisance covariate, in a multivariate model that also controlled for other factors contributing to pusher behavior. VLSM, combined with statistical non-parametric mapping (SnPM), identified the specific region with SCP. Lesion size was associated with lateropulsion. The precentral gyrus, postcentral gyrus, inferior frontal gyrus, insula and subgyral parietal lobe of the right hemisphere seemed to be associated with the lateropulsion; however, after adjusting for lesion volume as a nuisance covariate, no lesion areas were associated with the SCP scores. The size of the right hemisphere lesion was the only factor most strongly associated with lateropulsion in patients with stroke. These results may be useful for planning rehabilitation strategies of restoring vertical posture and understanding the pathophysiology of lateropulsion in stroke patients.

scholarly journals A-25Clinical Assessment of Posterior Cortical Atrophy

2016 ◽  
Vol 31 (6) ◽  
pp. 592.3-592
Author(s):  
G Wagner ◽  
J Rosen ◽  
G Holguin ◽  
B Frishberg ◽  
A Wang ◽  
...  
Keyword(s):  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

A case with cholinesterase inhibitor responsive asymmetric posterior cortical atrophy

2005 ◽  
Vol 108 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Eunhee Kim ◽  
Yunsoo Lee ◽  
Jongkeol Lee ◽  
Seol-Heui Han
Keyword(s):  
Cholinesterase Inhibitor ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy
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