scholarly journals Skull Metastasis as Initial Manifestation of Pulmonary Epithelial-Myoepithelial Carcinoma: A Case Report of an Unusual Case

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Masamitsu Nishihara ◽  
Naoya Takeda ◽  
Shoutarou Tatsumi ◽  
Keiji Kidoguchi ◽  
Shigeto Hayashi ◽  
...  
Keyword(s):  
Predictive Marker ◽  
Histopathological Study ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Left Hemiparesis ◽  
Intracranial Metastasis ◽  
Initial Manifestation ◽  
Skull Metastasis ◽  
Epithelial Myoepithelial Carcinoma ◽  
Mib 1

Epithelial-myoepithelial carcinoma (EMC) of the lung is rare and is considered to be low-grade malignancy. Intracranial metastasis of pulmonary EMC has not previously been reported according to our search of the literature. We report a case of skull metastasis as the initial manifestation of pulmonary EMC. An 81-year-old man complained of left leg motor weakness. Neurological examination showed left hemiparesis. Computed tomography and magnetic resonance imaging revealed an osteolytic tumor in the right frontal bone with invasion to the dura and subdural space, attached to the superior sagittal sinus. Subtotal removal of the tumor was performed, and the left hemiparesis showed improvement. Histopathological study revealed the tumor to consist of epithelial and myoepithelial cells. Pulmonary EMC was diagnosed. The MIB-1 index in primary lesion was approximately 10%. The skull and dura are possible sites for metastasis from pulmonary EMC. The MIB-1 index is a predictive marker of malignant potential.

scholarly journals A Case of Epithelial-Myoepithelial Carcinoma of Parotid Gland and Analysis of 33 Cases Reported in Korea

2021 ◽  
Vol 37 (2) ◽  
pp. 61-65
Author(s):  
Ji Won Kim ◽  
Min Soo Kim ◽  
Bo Sung Kim ◽  
Seong Dong Kim
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Low Frequency ◽  
Malignant Neoplasm ◽  
Clinicopathological Characteristics ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Regional Lymph Nodes ◽  
Retrospective Cohort Studies ◽  
Epithelial Myoepithelial Carcinoma

Epithelial-myoepithelial carcinoma is rare, low-grade malignant neoplasm that compromises approximately 1% of all salivary gland neoplasms. We reported a 68-year-old woman with epithelial-myoepithelial carcinoma in the parotid gland. We analyzed demographic and clinicopathological characteristics of salivary gland epithelial-myoepithelial carcinoma which has been reported in 33 cases in Korea from 1992 to 2017, and compared this result to overseas retrospective cohort studies. There was no significance in terms of mean age at diagnosis, the predominance of females, low frequency in regional lymph nodes, and distant metastasis between the two groups. However, T classification and AJCC stage at diagnosis in domestic cases are more advanced than those of overseas cases. Although the recurrence rate in domestic cases has been reported lower than that of overseas, further study may be needed considering that the follow-up period after treatment is short in domestic cases.

Epithelial-Myoepithelial Carcinoma of the Lung

2003 ◽  
Vol 127 (4) ◽  
pp. e177-e180 ◽  
Author(s):  
Latife Doganay ◽  
Selcuk Bilgi ◽  
Asli Ozdil ◽  
Yener Yoruk ◽  
Semsi Altaner ◽  
...  
Keyword(s):  
S100 Protein ◽  
Lower Lobe ◽  
Malignant Neoplasm ◽  
Myoepithelial Cells ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Primary Lung Tumors ◽  
Pulmonary Parenchyma ◽  
Epithelial Myoepithelial Carcinoma ◽  
Bronchial Glands

Abstract Primary lung tumors mimicking the salivary gland–type neoplasms are extremely rare. These types of tumors originate from submucosal bronchial glands. Epithelial-myoepithelial carcinoma is an uncommon tumor in this group, and only 7 cases have been reported. It is considered to be a low-grade malignant neoplasm. We report a case of epithelial-myoepithelial carcinoma of bronchial gland origin in a 73-year-old man who presented with coughing and dyspnea. The bronchus of the left lower lobe contained a tumor mass that had a polypoid growth pattern. The tumor also extended into the pulmonary parenchyma, forming a well-circumscribed mass with a pushing margin. The tumor consisted of epithelial and myoepithelial cells. The epithelial cells were positive for cytokeratins and epithelial membrane antigen, while the myoepithelial cells were positive for S100 protein and muscle-specific actin. According to these findings, we diagnosed epithelial-myoepithelial carcinoma. After undergoing pneumonectomy, the patient has been disease free for 34 months.

scholarly journals Epithelial–Myoepithelial Carcinoma of the Lacrimal Sac and Literature Review of the Lacrimal System

2020 ◽  
Vol 11 ◽  
pp. 215265672092060
Author(s):  
Dhruv Sharma ◽  
Ashley Neiweem ◽  
Kyle Davis ◽  
Mark Prendes ◽  
Rao Chundury ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Presentation ◽  
Definitive Treatment ◽  
Malignant Neoplasms ◽  
Low Grade ◽  
Open Approach ◽  
Myoepithelial Carcinoma ◽  
Lacrimal Sac ◽  
Lacrimal System ◽  
Epithelial Myoepithelial Carcinoma

Background Epithelial–myoepithelial carcinomas make up less than 0.1% of head and neck malignancies and are regarded as rare, low-grade malignant neoplasms of the salivary gland. They are thought to arise from intercalated ducts with histopathology showing a classic biphasic morphology of an outer layer of myoepithelial cells and inner layer of epithelial cells. These tumors most commonly occur in the parotid gland; however, rare cases have also been described in the nasal cavity, nasopharynx, subglottis, base of tongue, and the lacrimal gland. Objective To describe the clinical presentation, surgical management, and histopathology of the first reported case of lacrimal sac epithelial–myoepithelial carcinoma. To conduct a literature review of this malignancy, which is present in the lacrimal system. Methods Case report (n = 1) and literature review. Results We report a case of a 72-year-old man presenting with epiphora and a lacrimal sac mass with intranasal extension on imaging and nasal endoscopy. A combined endoscopic endonasal and open approach provided successful definitive treatment for final pathologic diagnosis of epithelial–myoepithelial carcinoma of the lacrimal sac, with orbital reconstruction and lacrimal stenting providing good cosmetic and functional results. Conclusions After PubMed database search for any case series or reports of lacrimal system epithelial–myoepithelial carcinomas, we believe this is the first documented case originating from the lacrimal sac. Although the histopathology of this tumor is distinct, unusual location and clinical presentation may pose significant diagnostic difficulties.

scholarly journals Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Salih Aydın ◽  
Umit Taskin ◽  
Kadir Ozdamar ◽  
Kadir Yücebas ◽  
Mehmet Sar ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Malignant Tumor ◽  
Malignant Tumors ◽  
Tumor Development ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Poorly Differentiated Adenocarcinoma ◽  
Poorly Differentiated ◽  
Epithelial Myoepithelial Carcinoma ◽  
Histopathological Results

Dedifferentiation is defined as high-grade malignant tumor development out of a low-grade malignant tumor. We present an adenocarcinoma tumor of the parotid gland that was dedifferentiated from a low-grade epithelial-myoepithelial carcinoma and was followed up for 3 years. Our patient, a 46-year-old female, presented with a left parotid mass of 20-year duration. Histopathologic results showed that there was only one area of typical epithelial-myoepithelial carcinoma, with foci of poorly differentiated adenocarcinoma (not otherwise specified; NOS) and clear cytoplasm in the parotid gland. Immunohistochemical staining results showed SMA (+), P63 (+), CK8 (+), and S100 (+) on epithelial cells. A review of the literature revealed 22 previously reported cases of dedifferentiated epithelial-myoepithelial carcinoma. In these cases, the malignant tumors that dedifferentiated from epithelial-myoepithelial carcinoma were adenoid cystic carcinoma, actinic cell carcinoma, polymorphous low-grade adenocarcinoma, mucoepidermoid carcinoma, and intraductal carcinoma. In our case, the malignant tumor that dedifferentiated from the epithelial-myoepithelial carcinoma was a poorly differentiated adenocarcinoma. Histopathological results showed that metastases were not seen in the neck-dissection material. As a result, our case will make a contribution to the literature in terms of prognosis, because there are very few reported cases of dedifferentiated adenocarcinoma development arising from epithelial-myoepithelial carcinoma.

Epithelial-Myoepithelial Carcinoma: A Low-Grade Malignancy in the Parotid Gland

2005 ◽  
Vol 34 (04) ◽  
pp. 231 ◽  
Author(s):  
Hiroki Yano ◽  
Hidehiro Tsutsumi ◽  
Katsumi Tanaka ◽  
Akiyoshi Hirano
Keyword(s):  
Parotid Gland ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Grade Malignancy ◽  
Epithelial Myoepithelial Carcinoma

An unusual presentation of aggressive epithelial-myoepithelial carcinoma of the nasal cavity with high-grade histology

2011 ◽  
Vol 125 (12) ◽  
pp. 1286-1289 ◽  
Author(s):  
J-O Park ◽  
C-K Jung ◽  
D-I Sun ◽  
M-S Kim
Keyword(s):  
Nasal Cavity ◽  
Rare Case ◽  
Low Grade ◽  
High Grade ◽  
Myoepithelial Carcinoma ◽  
Left Nasal Cavity ◽  
Unique Case ◽  
Medial Maxillectomy ◽  
Epithelial Myoepithelial Carcinoma

AbstractBackground:Epithelial-myoepithelial carcinoma is an uncommon, low-grade carcinoma that generally occurs in the salivary glands. A few cases of epithelial-myoepithelial carcinoma arising in the nasal cavity have been reported. We describe a unique case of aggressive epithelial-myoepithelial carcinoma in the nasal cavity.Case report:A 36-year-old woman presented with a mass in her left nasal cavity. Histopathological evaluation revealed it to be an epithelial-myoepithelial carcinoma with overt nuclear atypia, frequent mitoses and necrosis. The tumour recurred in the contralateral nasal cavity 15 months following primary excision. Medial maxillectomy and radiation therapy were performed. Seven-month follow up revealed extensive bone metastases.Conclusion:We report a rare case of aggressive epithelial-myoepithelial carcinoma in the nasal cavity, with high-grade histology.

scholarly journals Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2124
Author(s):  
Kohei Okuyama ◽  
Yasuyuki Michi ◽  
Yoshihisa Kashima ◽  
Hirofumi Tomioka ◽  
Hideaki Hirai ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumor ◽  
Case Series ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Minor Salivary Glands ◽  
Comprehensive Review ◽  
Epithelial Myoepithelial Carcinoma

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells, which is especially uncommon in the minor salivary glands (MSG). Because of its histologic variety, complexity, and heterogeneity, it is sometimes challenging to make the accurate diagnosis. Here, we report a literature review of EMC of the MSGs with our experience of two cases. Incisional biopsy was suggestive of pleomorphic adenoma in Case 1 and pleomorphic adenoma or a low-grade salivary gland carcinoma in Case 2. Both cases were performed intraoral tumor resection, and they have good postoperative courses and are alive with no evidence of local recurrence or metastasis at 31 and 16 months, respectively. Considering that the anatomy, structure, and size of salivary glands are quite different from MSGs, it might be difficult to predict EMCs of the MSG similarly to EMCs of the major salivary glands. This comprehensive review also reports the features of EMC of the MSG cases and the trends of diagnosis and discusses treatment strategy.

scholarly journals Epithelial-Myoepithelial Carcinoma of the Salivary Gland

2013 ◽  
Vol 28 (1) ◽  
pp. 36-37
Author(s):  
Jose M. Carnate ◽  
José Florencio F. Lapeña
Keyword(s):  
Salivary Gland ◽  
Cell Types ◽  
Myoepithelial Cells ◽  
World Health ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
S 100 ◽  
Grade Malignancy ◽  
Epithelial Myoepithelial Carcinoma ◽  
Health Organization

The World Health Organization  (2005) defines an epithelial-myoepithelial carcinoma (EMC) as a malignancy composed of two cell types that typically form duct-like structures.1 We present herein an archival case from the parotid gland.   EMC occurs primarily in the major salivary glands particularly in the parotid where it presents as a painless, slow-growing mass.1  Microscopic examination shows bi-layered tubular duct-like structures with pale to clear areas (Figure 1). The inner luminal layer is composed of cuboidal cells that are of epithelial derivation while the outer layer is composed  of polygonal cells that are of myoepithelial derivation (Figures 2 and 3). The latter typically have abundant clear cytoplasm.1,2 The  epithelial-myoepithelial  dualism is confirmed using immunohistochemical  stains; the epithelial cells being immunoreactive  for low molecular weight keratin and the myoepithelial cells for S-100 protein, muscle specific actin, vimentin and p63.1, 3   EMC is primarily a tumor of adulthood with peak incidence in the sixth and seventh decades. First described by Donath et al. in 1972,3   they are rare salivary gland neoplasms with an incidence of less than 1% arising mainly in the parotid gland4   although they have been documented in the lungs.5  Perineural and vascular invasion are frequent and recurrence occurs in around 40% of cases and metastasis in 14%.1 Although thought to be of low-grade malignancy, fatal courses have been described4  and “analysis of the various series have demonstrated that tumors with a solid growing pattern, nuclear atypia, DNA aneuploidy and high proliferative activity, generally have a more aggressive behavior and a higher frequency of local recurrences and metastases.”3

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