scholarly journals A Case of Epithelial-Myoepithelial Carcinoma of Parotid Gland and Analysis of 33 Cases Reported in Korea

2021 ◽  
Vol 37 (2) ◽  
pp. 61-65
Author(s):  
Ji Won Kim ◽  
Min Soo Kim ◽  
Bo Sung Kim ◽  
Seong Dong Kim
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Low Frequency ◽  
Malignant Neoplasm ◽  
Clinicopathological Characteristics ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Regional Lymph Nodes ◽  
Retrospective Cohort Studies ◽  
Epithelial Myoepithelial Carcinoma

Epithelial-myoepithelial carcinoma is rare, low-grade malignant neoplasm that compromises approximately 1% of all salivary gland neoplasms. We reported a 68-year-old woman with epithelial-myoepithelial carcinoma in the parotid gland. We analyzed demographic and clinicopathological characteristics of salivary gland epithelial-myoepithelial carcinoma which has been reported in 33 cases in Korea from 1992 to 2017, and compared this result to overseas retrospective cohort studies. There was no significance in terms of mean age at diagnosis, the predominance of females, low frequency in regional lymph nodes, and distant metastasis between the two groups. However, T classification and AJCC stage at diagnosis in domestic cases are more advanced than those of overseas cases. Although the recurrence rate in domestic cases has been reported lower than that of overseas, further study may be needed considering that the follow-up period after treatment is short in domestic cases.

Epithelial-Myoepithelial Carcinoma of the Lung

2003 ◽  
Vol 127 (4) ◽  
pp. e177-e180 ◽  
Author(s):  
Latife Doganay ◽  
Selcuk Bilgi ◽  
Asli Ozdil ◽  
Yener Yoruk ◽  
Semsi Altaner ◽  
...  
Keyword(s):  
S100 Protein ◽  
Lower Lobe ◽  
Malignant Neoplasm ◽  
Myoepithelial Cells ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Primary Lung Tumors ◽  
Pulmonary Parenchyma ◽  
Epithelial Myoepithelial Carcinoma ◽  
Bronchial Glands

Abstract Primary lung tumors mimicking the salivary gland–type neoplasms are extremely rare. These types of tumors originate from submucosal bronchial glands. Epithelial-myoepithelial carcinoma is an uncommon tumor in this group, and only 7 cases have been reported. It is considered to be a low-grade malignant neoplasm. We report a case of epithelial-myoepithelial carcinoma of bronchial gland origin in a 73-year-old man who presented with coughing and dyspnea. The bronchus of the left lower lobe contained a tumor mass that had a polypoid growth pattern. The tumor also extended into the pulmonary parenchyma, forming a well-circumscribed mass with a pushing margin. The tumor consisted of epithelial and myoepithelial cells. The epithelial cells were positive for cytokeratins and epithelial membrane antigen, while the myoepithelial cells were positive for S100 protein and muscle-specific actin. According to these findings, we diagnosed epithelial-myoepithelial carcinoma. After undergoing pneumonectomy, the patient has been disease free for 34 months.

scholarly journals Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Salih Aydın ◽  
Umit Taskin ◽  
Kadir Ozdamar ◽  
Kadir Yücebas ◽  
Mehmet Sar ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Malignant Tumor ◽  
Malignant Tumors ◽  
Tumor Development ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Poorly Differentiated Adenocarcinoma ◽  
Poorly Differentiated ◽  
Epithelial Myoepithelial Carcinoma ◽  
Histopathological Results

Dedifferentiation is defined as high-grade malignant tumor development out of a low-grade malignant tumor. We present an adenocarcinoma tumor of the parotid gland that was dedifferentiated from a low-grade epithelial-myoepithelial carcinoma and was followed up for 3 years. Our patient, a 46-year-old female, presented with a left parotid mass of 20-year duration. Histopathologic results showed that there was only one area of typical epithelial-myoepithelial carcinoma, with foci of poorly differentiated adenocarcinoma (not otherwise specified; NOS) and clear cytoplasm in the parotid gland. Immunohistochemical staining results showed SMA (+), P63 (+), CK8 (+), and S100 (+) on epithelial cells. A review of the literature revealed 22 previously reported cases of dedifferentiated epithelial-myoepithelial carcinoma. In these cases, the malignant tumors that dedifferentiated from epithelial-myoepithelial carcinoma were adenoid cystic carcinoma, actinic cell carcinoma, polymorphous low-grade adenocarcinoma, mucoepidermoid carcinoma, and intraductal carcinoma. In our case, the malignant tumor that dedifferentiated from the epithelial-myoepithelial carcinoma was a poorly differentiated adenocarcinoma. Histopathological results showed that metastases were not seen in the neck-dissection material. As a result, our case will make a contribution to the literature in terms of prognosis, because there are very few reported cases of dedifferentiated adenocarcinoma development arising from epithelial-myoepithelial carcinoma.

scholarly journals Low Grade Central Mucoepidermoid Carcinoma

2015 ◽  
Vol 5 (1) ◽  
pp. 31-34
Author(s):  
Kartik Poonja ◽  
Janaki Subramanian Iyer ◽  
Leela Poonja
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Male Patient ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumor ◽  
Malignant Neoplasm ◽  
Low Grade ◽  
Gland Tumor ◽  
Malignant Salivary Gland Tumor ◽  
Central Mucoepidermoid Carcinoma

ABSTRACT Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, comprising about 15% of all salivary gland tumors and 30% of all salivary malignancies. Most of the MEC arise in the parotid gland. Rarely, it originates in the mandible and maxilla as an intraosseous variant, referred to as ‘central mucoepidermoid carcinoma’ or ‘intraosseous mucoepidermoid carcinoma’. Central mucoepidermoid carcinomas (CMECs) are extremely rare, but well-known entity, comprising 2 to 3% of all MECs reported. Histopathologically, this malignant neoplasm is characterized by mucous, intermediate and epidermoid cells. In this report, we present a case of a male patient diagnosed as low grade CMEC. How to cite this article Iyer JS, Poonja K, Pathak J, Patel S, Poonja L. Low Grade Central Mucoepidermoid Carcinoma. J Contemp Dent 2015;5(1):31-34.

Epithelial-Myoepithelial Carcinoma: A Low-Grade Malignancy in the Parotid Gland

2005 ◽  
Vol 34 (04) ◽  
pp. 231 ◽  
Author(s):  
Hiroki Yano ◽  
Hidehiro Tsutsumi ◽  
Katsumi Tanaka ◽  
Akiyoshi Hirano
Keyword(s):  
Parotid Gland ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Grade Malignancy ◽  
Epithelial Myoepithelial Carcinoma

scholarly journals Epithelial-Myoepithelial Carcinoma of the Minor Salivary Glands: Case Series with Comprehensive Review

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2124
Author(s):  
Kohei Okuyama ◽  
Yasuyuki Michi ◽  
Yoshihisa Kashima ◽  
Hirofumi Tomioka ◽  
Hideaki Hirai ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumor ◽  
Case Series ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
Minor Salivary Glands ◽  
Comprehensive Review ◽  
Epithelial Myoepithelial Carcinoma

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells, which is especially uncommon in the minor salivary glands (MSG). Because of its histologic variety, complexity, and heterogeneity, it is sometimes challenging to make the accurate diagnosis. Here, we report a literature review of EMC of the MSGs with our experience of two cases. Incisional biopsy was suggestive of pleomorphic adenoma in Case 1 and pleomorphic adenoma or a low-grade salivary gland carcinoma in Case 2. Both cases were performed intraoral tumor resection, and they have good postoperative courses and are alive with no evidence of local recurrence or metastasis at 31 and 16 months, respectively. Considering that the anatomy, structure, and size of salivary glands are quite different from MSGs, it might be difficult to predict EMCs of the MSG similarly to EMCs of the major salivary glands. This comprehensive review also reports the features of EMC of the MSG cases and the trends of diagnosis and discusses treatment strategy.

scholarly journals Epithelial-Myoepithelial Carcinoma of the Salivary Gland

2013 ◽  
Vol 28 (1) ◽  
pp. 36-37
Author(s):  
Jose M. Carnate ◽  
José Florencio F. Lapeña
Keyword(s):  
Salivary Gland ◽  
Cell Types ◽  
Myoepithelial Cells ◽  
World Health ◽  
Low Grade ◽  
Myoepithelial Carcinoma ◽  
S 100 ◽  
Grade Malignancy ◽  
Epithelial Myoepithelial Carcinoma ◽  
Health Organization

The World Health Organization  (2005) defines an epithelial-myoepithelial carcinoma (EMC) as a malignancy composed of two cell types that typically form duct-like structures.1 We present herein an archival case from the parotid gland.   EMC occurs primarily in the major salivary glands particularly in the parotid where it presents as a painless, slow-growing mass.1  Microscopic examination shows bi-layered tubular duct-like structures with pale to clear areas (Figure 1). The inner luminal layer is composed of cuboidal cells that are of epithelial derivation while the outer layer is composed  of polygonal cells that are of myoepithelial derivation (Figures 2 and 3). The latter typically have abundant clear cytoplasm.1,2 The  epithelial-myoepithelial  dualism is confirmed using immunohistochemical  stains; the epithelial cells being immunoreactive  for low molecular weight keratin and the myoepithelial cells for S-100 protein, muscle specific actin, vimentin and p63.1, 3   EMC is primarily a tumor of adulthood with peak incidence in the sixth and seventh decades. First described by Donath et al. in 1972,3   they are rare salivary gland neoplasms with an incidence of less than 1% arising mainly in the parotid gland4   although they have been documented in the lungs.5  Perineural and vascular invasion are frequent and recurrence occurs in around 40% of cases and metastasis in 14%.1 Although thought to be of low-grade malignancy, fatal courses have been described4  and “analysis of the various series have demonstrated that tumors with a solid growing pattern, nuclear atypia, DNA aneuploidy and high proliferative activity, generally have a more aggressive behavior and a higher frequency of local recurrences and metastases.”3

Terminal duct adenocarcinomas of the parotid gland

1995 ◽  
Vol 109 (5) ◽  
pp. 466-468 ◽  
Author(s):  
Bonnie L. Kemp ◽  
John G. Batsakis ◽  
Adel K. El-Naggar ◽  
Sophia N. Kotliar ◽  
Mario A. Luna
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Biological Behaviour ◽  
Parotid Neoplasms ◽  
Clinicopathological Study

AbstractThe major salivary glands are considered to rarely be the sites of primary terminal duct adenocarcinomas, a neoplasm with a considerable predilection for origin from intraoral minor salivary glands. We present a clinicopathological study of 22 terminal duct adenocarcinomas of the parotid gland, the largest single series to date. A comparison between the parotid neoplasms and over 200 minor salivary gland terminal duct adenocarcinomas indicates there is little difference in biological behaviour and confirms the low-grade quality of the carcinomas, regardless of site of origin.

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