scholarly journals Extranodal NK/T-Cell Lymphoma: Toward the Identification of Clinical Molecular Targets

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Christian Schmitt ◽  
Nouhoum Sako ◽  
Martine Bagot ◽  
Yenlin Huang ◽  
Philippe Gaulard ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Epstein Barr Virus Infection ◽  
Cytotoxic Lymphocytes ◽  
Barr Virus ◽  
Nk T Cell ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Hodgkin's Lymphomas

Extranodal natural killer (NK)/T-cell lymphoma of nasal type (NKTCL) is a malignant disorder of cytotoxic lymphocytes of NK or more rarely T cells associated with clonal Epstein-Barr virus infection. Extranodal NKTCL is rare in Western countries, but in Asia and Central and South America it can account for up to10%of non-Hodgkin's lymphomas. It is an aggressive neoplasm with very poor prognosis. Although the pathogenesis of extranodal NKTCL remains poorly understood, some insights have been gained in the recent years, especially from genome-wide studies. Based on our own experience and knowledge of the literature, we here review some of the genomic and functional pathway alterations observed in NKTCL that could provide a rationale for the development of innovative therapeutic strategies.

Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection

2006 ◽  
Vol 97 (7) ◽  
pp. 605-610 ◽  
Author(s):  
Angen Liu ◽  
Tetsuya Takakuwa ◽  
Wen-Juan Luo ◽  
Shigeki Fujita ◽  
Katsuyuki Aozasa
Keyword(s):  
T Cell ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Nk T Cell ◽  
Epstein Barr ◽  
Barr Virus Infection

Human Ia-Like-Antigen-Expressed Cutaneous T Cell Lymphoma Associated with Epstein-Barr Virus Infection

Dermatology ◽  
1982 ◽  
Vol 165 (2) ◽  
pp. 100-107
Author(s):  
Fukumi Furukawa ◽  
Motoi Oguchi ◽  
Momoyo Hashimoto ◽  
Susumu Ohkawa ◽  
Motoaki Ozaki ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Epstein Barr Virus Infection ◽  
Cutaneous T Cell Lymphoma ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Nasal T-cell lymphoma associated with Epstein-Barr virus infection

1993 ◽  
Vol 107 (5) ◽  
pp. 468-470 ◽  
Author(s):  
J. Dhaliwal ◽  
D. C. Rowlands ◽  
G. Niedobitek ◽  
A. Williams ◽  
A. Das Gupta ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
T Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

A case of nasal T-cell lymphoma in a Caucasian male is reported, in which the presence of Epstein-Barr virus within tumour cells was demonstrated by in situ hybridization to the Epstein-Barr virus encoded RNAs EBER-1 and EBER-2.

scholarly journals Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
X. A. Andrade ◽  
H. E. Fuentes ◽  
D. M. Oramas ◽  
H. Mann ◽  
P. Kovarik
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cell ◽  
Cell Lymphoma ◽  
Complete Response ◽  
T Cell Lymphoma ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Increased Risk ◽  
Epstein Barr ◽  
Barr Virus Infection

Patients with rheumatoid arthritis are at increased risk of hematological malignancies, especially when exposed to immunosuppressive therapy. The mechanisms of lymphomagenesis remain poorly understood but factors implicated include high disease activity, exposure to antitumoral necrosis factor medications, and Epstein–Barr virus infection. Lymphoid malignancies of T-cell origin are uncommon in patients with rheumatoid arthirits. Clinical presentation with associated hemophagocytic lymphohistiocyotsis is rare and confers a poor prognosis. This case report illustrates a case of a patient with long-standing rheumatoid arthritis and an iatrogenic peripheral T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis who achieved a complete response after intensive chemotherapy.

scholarly journals One method to establish Epstein-Barr virus-associated NK/T cell lymphoma mouse models

2018 ◽  
Vol 23 (2) ◽  
pp. 1509-1516
Author(s):  
Weili Xue ◽  
Weiming Li ◽  
Yufeng Shang ◽  
Yanjie Zhang ◽  
Xuan Lan ◽  
...  
Keyword(s):  
T Cell ◽  
Mouse Models ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Barr Virus ◽  
Nk T Cell ◽  
Epstein Barr

Epstein-Barr virus-induced natural killer/T cell lymphoma arising in tonsil and cervical node tissue

2021 ◽  
Vol 14 (11) ◽  
pp. e235100
Author(s):  
Adora Tricia Santos ◽  
Jiankun Tong ◽  
Amir Steinberg ◽  
Larry Shemen
Keyword(s):  
T Cell ◽  
Natural Killer ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Early Recognition ◽  
T Cell Lymphoma ◽  
Unique Type ◽  
Barr Virus ◽  
Nk T Cell ◽  
Epstein Barr

Infection with Epstein-Barr virus (EBV) has been linked to approximately 10%–15% of lymphomas diagnosed in the USA, including a small percentage of Natural Killer (NK)/T cell lymphomas, which are clinically aggressive, respond poorly to chemotherapy and have a shorter survival. Here, we present a case of a patient found to have EBV-induced NK/T cell lymphoma from a chronic EBV infection. While the EBV most commonly infects B cells, it can infect NK/T cells, and it is important for the clinician to be aware of the potential transformation to lymphoma as it is clinically aggressive, warranting early recognition and treatment. NK/T cell lymphoma is a unique type of non-Hodgkin's lymphoma that is almost always associated with EBV. The disease predominantly localises in the upper aerodigestive tract, most commonly in the nose.

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