scholarly journals Role of Brush Biopsy and DNA Cytometry for Prevention, Diagnosis, Therapy, and Followup Care of Oral Cancer

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Alfred Böcking ◽  
Christoph Sproll ◽  
Nikolas Stöcklein ◽  
Christian Naujoks ◽  
Rita Depprich ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Image Cytometry ◽  
Accurate Method ◽  
Resection Margins ◽  
Brush Biopsy ◽  
Oral Cancers ◽  
Locoregional Failure ◽  
Late Treatment ◽  
Diagnosis Therapy ◽  
Dna Image Cytometry

Late diagnosis resulting in late treatment and locoregional failure after surgery are the main causes of death in patients with oral squamous cell carcinomas (SCCs). Actually, exfoliative cytology is increasingly used for early detection of oral cancer and has been the subject of intense research over the last five years. Significant advances have been made both in relation to screening and evaluation of precursor lesions. As this noninvasive procedure is well tolerated by patients, more lesions may be screened and thus more oral cancers may be found in early, curable stages. Moreover, the additional use of DNA image cytometry is a reasonable tool for the assessment of the resection margins of SCC. DNA image cytometry could help to find the appropriate treatment option for the patients. Finally, diagnostic DNA image cytometry is an accurate method and has internationally been standardized. In conclusion, DNA image cytometry has increasing impact on the prevention, diagnostic, and therapeutical considerations in head and neck SCC.

scholarly journals Earliest Detection of Oral Cancer Using Non-Invasive Brush Biopsy Including DNA-Image-Cytometry: Report on Four Cases

2003 ◽  
Vol 25 (4) ◽  
pp. 159-166 ◽  
Author(s):  
Torsten W. Remmerbach ◽  
Horst Weidenbach ◽  
Alexander Hemprich ◽  
Alfred Böcking
Keyword(s):  
Oral Cancer ◽  
Case Reports ◽  
Image Cytometry ◽  
Severe Dysplasia ◽  
Brush Biopsy ◽  
Oral Cancers ◽  
Non Invasive ◽  
Dna Measurements ◽  
Dna Image Cytometry

Objective: We describe four patients presenting early oral cancers, detected cytologically on non‐invasive brush biopsies including DNA‐image cytometry as an adjunctive method before histology on scalpel biopsies confirmed the evidence of malignancy.Methods: Brush biopsies were performed and smears thereof investigated cytologically. After Feulgen restaining, DNA‐measurements were performed using a DNA‐Image‐Cytometer.Case reports: Oral squamous cell carcinomas were diagnosed cytologically in macroscopically suspicious lesions and malignancy confirmed by DNA‐cytometry. The initially performed scalpel biopsies did neither supply evidence of oral cancer nor of severe dysplasia. After at least one to 15 months the occurrence of cancer was finally proven histologically on a second scalpel biopsy each (three microinvasive and onein situcarcinoma).Conclusion: Non‐invasive brush biopsies are a suitable instrument for early cytologic detection of cancer of the mouth. DNA‐image‐cytometry, as an adjunctive method, can be used to confirm the cytologic diagnosis or suspicion of cancer in patients with doubtful lesions (dysplasias). DNA‐aneuploidy is a marker for (prospective) malignancy in smears of the oral cavity, which may detect malignancy months prior to histology. In future this method could be used as a mass screening tool in dentists practise. Colour figures can be viewed onhttp://www.esacp.org/acp/2003/25‐4/remmerbach.htm.

O.151 DNA-image cytometry improves assessment of resection margins

2008 ◽  
Vol 36 ◽  
pp. S38-S39
Author(s):  
J. Handschel ◽  
C. Sproll ◽  
R. Depprich ◽  
A. Zimmermann ◽  
S. Braunstein ◽  
...  
Keyword(s):  
Image Cytometry ◽  
Resection Margins ◽  
Dna Image Cytometry

Additional use of DNA-image cytometry improves the assessment of resection margins

2007 ◽  
Vol 36 (8) ◽  
pp. 472-475 ◽  
Author(s):  
Jörg Handschel ◽  
Döne Öz ◽  
Natalia Pomjanski ◽  
Rita Depprich ◽  
Michelle A. Ommerborn ◽  
...  
Keyword(s):  
Image Cytometry ◽  
Resection Margins ◽  
Dna Image Cytometry

scholarly journals Evaluation of Serum Immunoglobulins (IgG, IgA, IgM) and Circulating Immune Complexes in Oral Precancer and Cancer Patients

2021 ◽  
Author(s):  
Pooja Madki ◽  
Mandya Lakshman Avinash Tejasvi ◽  
Geetha Paramkusam ◽  
Ruheena Khan ◽  
Shilpa J.
Keyword(s):  
Oral Cancer ◽  
Immune Complexes ◽  
Serum Levels ◽  
Circulating Immune Complexes ◽  
Oral Cancers ◽  
Cancer Group ◽  
Oral Precancer ◽  
Serum Iga ◽  
The Mean

Abstract Objectives The aim of the present study is to evaluate the role of immunoglobulins (IgA, IgG, and IgM) and circulating immune complexes (CIC) as tumor marker in oral cancer and precancer patients. Materials and Methods The present study was performed on 45 individuals subdivided into three groups, that is, oral precancer, oral cancer and healthy individuals, and levels of immunoglobulins, and CIC was estimated by turbidometry and ELISA method. Results In the present study, the mean serum IgA levels in oral precancer were 161.00 ( ±  118.02) mg/dL, oral cancers were 270.67 ( ±  171.44) mg/dL, and controls were 133.73 ( ±  101.31) mg/dL. Mean serum levels of IgG in oral precancer were 1,430.87 ( ±  316) mg/dL, oral cancers were 1,234.27 ( ±  365.42) mg/dL, and controls were 593.87 ( ±  323.06) mg/dL. Conclusion We found that the levels of serum IgG and IgA were elevated consistently in precancer and cancer group, and Serum IgM levels were increased only in precancer. Also, significant increase in serum CIC levels were seen in oral precancer and cancer group on comparison with control.

scholarly journals Additional Techniques in Serous Effusions

2002 ◽  
Vol 24 (1) ◽  
pp. 1-4 ◽  
Author(s):  
A. G. J. M. Hanselaar
Keyword(s):  
Flow Cytometry ◽  
Malignant Mesothelioma ◽  
Peritoneal Cavity ◽  
Diagnostic Tool ◽  
Image Cytometry ◽  
Serous Effusion ◽  
Cytological Examination ◽  
Valuable Diagnostic Tool ◽  
Carcinoma Of The Ovary ◽  
Dna Image Cytometry

Cytological examination is a valuable diagnostic tool in case of a serous effusion. The firstmanifestation of malignancy may be an effusion of the pleural, pericardial, or peritoneal cavity, especially in carcinoma of the ovary, or lung, and malignant mesothelioma. In other malignancies effusions may occur in the course of the disease. The contribution by Motherby et al. in this issue of ACP focuses on the contribution of image and flow cytometry to establish the presence or absence of malignancy in serous effusions [16]. They point out that the sensitivity of DNA image cytometry in equivocal effusions may be as high as 87.5%, and that for the detection of malignancy, DNA image cytometry is superior to flow cytometry.

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