scholarly journals The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Susan Yung ◽  
Tak Mao Chan
Keyword(s):  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Inflammatory Responses ◽  
Tissue Injury ◽  
Cell Surface Receptor ◽  
Systemic Lupus ◽  
Permanent Damage ◽  
Immune Mediated ◽  
Surface Receptor

Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that affects multiorgan systems. Lupus nephritis is one of the most severe manifestations of SLE whereby immune-mediated inflammation can lead to permanent damage within the glomerular, tubulo-interstitial, and vascular compartments of the kidney, resulting in acute or chronic renal failure. The mechanisms that regulate host inflammatory responses and tissue injury are incompletely understood. Accumulating evidence suggests that hyaluronan and its interaction with its cell surface receptor CD44 plays an important role in mediating pathogenic mechanisms in SLE. This paper discusses the putative mechanisms through which hyaluronan and CD44 contribute to the pathogenesis of SLE, with particular emphasis on lupus nephritis.

scholarly journals Phoenix from the flames: Rediscovering the role of the CD40–CD40L pathway in systemic lupus erythematosus and lupus nephritis

2020 ◽  
Vol 19 (11) ◽  
pp. 102668
Author(s):  
Meera Ramanujam ◽  
Jürgen Steffgen ◽  
Sudha Visvanathan ◽  
Chandra Mohan ◽  
Jay S. Fine ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals The Role of NLRP3 Inflammasome in Lupus Nephritis

2021 ◽  
Vol 22 (22) ◽  
pp. 12476
Author(s):  
Camila Barbosa Oliveira ◽  
Camilla Albertina Dantas Lima ◽  
Gisele Vajgel ◽  
Paula Sandrin-Garcia
Keyword(s):  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Nlrp3 Inflammasome ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Functional Studies ◽  
Pyrin Domain ◽  
Therapeutic Drugs ◽  
Pro Inflammatory Cytokines

Lupus nephritis (LN) is the most frequent and severe of systemic lupus erythematosus (SLE) clinical manifestations and contributes to the increase of morbidity and mortality of patients due to chronic kidney disease. The NLRP3 (NLR pyrin domain containing 3) is a member of the NLR (NOD-like receptors), and its activation results in the production of pro-inflammatory cytokines, which can contribute to the pathogenesis of LN. In this review manuscript, we approach the relation between the NLRP3 inflammasome, SLE, and LN, highlighting the influence of genetic susceptibility of NLRP3 polymorphisms in the disease; the main functional studies using cellular and animal models of NLRP3 activation; and finally, some mechanisms of NLRP3 inhibition for the development of possible therapeutic drugs for LN.

scholarly journals Intestinal macrophages in mucosal immunity and their role in systemic lupus erythematosus disease

Lupus ◽  
2018 ◽  
Vol 27 (12) ◽  
pp. 1898-1902 ◽  
Author(s):  
F Pan ◽  
W Tang ◽  
Z Zhou ◽  
G Gilkeson ◽  
R Lang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Immune Responses ◽  
Lupus Erythematosus ◽  
Inflammatory Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Systemic Lupus ◽  
Innate Immune Signaling ◽  
Immune Signaling Pathway

Monocytes play an important role in inducing host systemic immunity against invading pathogens and inflammatory responses. After activation, monocytes migrate to tissue sites, where they initiate both innate and adaptive immune responses, and become macrophages. Although mucosal macrophages produce inflammatory cytokines in response to pathogens, the perturbations in innate immune signaling pathway have been implicated in autoimmune diseases such as systemic lupus erythematosus (SLE). In this review, we focus on the role of human macrophages in intestinal innate immune responses, homeostasis, and SLE disease. We further discuss sex differences in the intestinal macrophages and their role in the physiology and pathogenesis of SLE.

scholarly journals Role of syndecan-1 (CD138) in Egyptian systemic lupus erythematosus patients with lupus nephritis: Relation to disease activity

2019 ◽  
Vol 41 (4) ◽  
pp. 289-294
Author(s):  
Randa F. Salam ◽  
Noha M. Khalil ◽  
Alshaimaa R. Alnaggar ◽  
Osama Mohamady ◽  
Amina Maher ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Nephritis ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals CD107a+ (LAMP-1) Cytotoxic CD8+ T-Cells in Lupus Nephritis Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Anika Wiechmann ◽  
Benjamin Wilde ◽  
Bartosz Tyczynski ◽  
Kerstin Amann ◽  
Wayel H. Abdulahad ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
Lupus Nephritis ◽  
Cd8 T Cells ◽  
Lupus Erythematosus ◽  
Inactive Disease ◽  
Healthy Controls ◽  
Systemic Lupus ◽  
Altered Expression

Cytotoxic CD8+ T-cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The aim of this study was to investigate the role of CD107a (LAMP-1) on cytotoxic CD8+ T-cells in SLE-patients in particular with lupus nephritis. Peripheral blood of SLE-patients (n = 31) and healthy controls (n = 21) was analyzed for the expression of CD314 and CD107a by flow cytometry. Kidney biopsies of lupus nephritis patients were investigated for the presence of CD8+ and C107a+ cells by immunohistochemistry and immunofluorescence staining. The percentages of CD107a+ on CD8+ T-cells were significantly decreased in SLE-patients as compared to healthy controls (40.2 ± 18.5% vs. 47.9 ± 15.0%, p = 0.02). This was even more significant in SLE-patients with inactive disease. There was a significant correlation between the percentages of CD107a+CD8+ T-cells and SLEDAI. The evaluation of lupus nephritis biopsies showed a significant number of CD107a+CD8+ T-cells mainly located in the peritubular infiltrates. The intrarenal expression of CD107a+ was significantly correlated with proteinuria. These results demonstrate that CD8+ T-cells of patients with systemic lupus erythematosus have an altered expression of CD107a which seems to be associated with disease activity. The proof of intrarenal CD107a+CD8+ suggests a role in the pathogenesis of lupus nephritis.

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