Otic Langerhans' Cell Histiocytosis in an Adult: A Case Report and Review of the Literature

Objective. To present a case of otic Langerhans' cell histiocytosis in an adult. Also included the diagnosis and management of the condition and a review of the relevant literature.Case Report. We report a case of a 41-year-old man with a history of persistent unilateral ear discharge associated with an aural polyp. Radiological imaging showed bony lesions of the skull and a soft-tissue mass within the middle ear. Histological analysis of the polyp demonstrated Langerhans' cell histiocytosis. His otological symptoms were completely resolved with the systemic therapy.Conclusions. Otic Langerhans' cell histiocytosis can present in adults. Persistent ear symptoms along with evidence of soft-tissue masses within the ear and bony lesions of the skull or elsewhere should prompt the otolaryngologists to include Langerhans' cell histiocytosis in their differential diagnosis. Management should be with systemic therapy rather than local surgical treatment.

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Soft Tissue Mass as a Presenting Symptom in Langerhans—Cell Histiocytosis

Pediatric Hematology and Oncology ◽

10.3109/08880018809037373 ◽

1988 ◽

Vol 5 (4) ◽

pp. 319-324 ◽

Cited By ~ 3

Author(s):

Y. Frishberg ◽

B. Stark ◽

C. Mor ◽

M. Mukamel ◽

I. Yaniv ◽

...

Keyword(s):

Soft Tissue ◽

Langerhans Cell Histiocytosis ◽

Soft Tissue Mass ◽

Langerhans Cell ◽

Tissue Mass

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Langerhans cell histiocytosis of atlantoaxial joint in a middle-aged man presenting with deafness as first symptom and soft-tissue mass at neck showing excellent response to radiotherapy alone: Report of an extremely rare and unusual clinical condition and review of literature

Annals of Indian Academy of Neurology ◽

10.4103/0972-2327.144022 ◽

2014 ◽

Vol 17 (4) ◽

pp. 429 ◽

Cited By ~ 1

Author(s):

Dodul Mondal ◽

PK Julka ◽

Manisha Jana ◽

Ritika Walia ◽

Tamojit Chaudhuri

Keyword(s):

Soft Tissue ◽

Clinical Condition ◽

Langerhans Cell Histiocytosis ◽

Soft Tissue Mass ◽

Langerhans Cell ◽

Atlantoaxial Joint ◽

Review Of Literature ◽

Tissue Mass ◽

Excellent Response ◽

Radiotherapy Alone

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Extraskeletal soft tissue masses of Langerhans' cell histiocytosis

Skeletal Radiology ◽

10.1007/s002560050107 ◽

1996 ◽

Vol 25 (4) ◽

pp. 409-412 ◽

Cited By ~ 12

Author(s):

Mark E. Henck ◽

E. L. Simpson ◽

Richard H. Ochs ◽

Joseph L. Eremus

Keyword(s):

Soft Tissue ◽

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Soft Tissue Masses

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The Rapid Evolution of CT Findings in Pulmonary Langerhans Cell Histiocytosis: A Case Report

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2007.57.1.27 ◽

2007 ◽

Vol 57 (1) ◽

pp. 27

Author(s):

Tae Wook Kang ◽

Kyung Soo Lee ◽

Eun Yoon Cho

Keyword(s):

Case Report ◽

Langerhans Cell Histiocytosis ◽

Rapid Evolution ◽

Langerhans Cell ◽

Pulmonary Langerhans Cell Histiocytosis ◽

Ct Findings

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Soft tissue masses: distribution of entities and rate of malignancy in small lesions

BMC Cancer ◽

10.1186/s12885-020-07769-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Felix G. Gassert ◽

Florian T. Gassert ◽

Katja Specht ◽

Carolin Knebel ◽

Ulrich Lenze ◽

...

Keyword(s):

Soft Tissue ◽

Benign Lesion ◽

Maximum Diameter ◽

Histopathological Diagnosis ◽

Tumor Diameter ◽

Mr Images ◽

Tissue Mass ◽

Malignancy Rate ◽

Significant Difference ◽

Soft Tissue Masses

Abstract Background Small soft tissue masses are often falsely assumed to be benign and resected with failure to achieve tumor-free margins. Therefore, this study retrospectively investigated the distribution of histopathologic diagnosis to be encountered in small soft tissue tumors (≤ 5 cm) in a large series of a tertiary referral center. Methods Patients with a soft tissue mass (STM) with a maximum diameter of 5 cm presenting at our institution over a period of 10 years, who had undergone preoperative Magnetic resonance imaging and consequent biopsy or/and surgical resection, were included in this study. A final histopathological diagnosis was available in all cases. The maximum tumor diameter was determined on MR images by one radiologist. Moreover, tumor localization (head/neck, trunk, upper extremity, lower extremity, hand, foot) and depth (superficial / deep to fascia) were assessed. Results In total, histopathologic results and MR images of 1753 patients were reviewed. Eight hundred seventy patients (49.63%) showed a STM ≤ 5 cm and were therefore included in this study (46.79 +/− 18.08 years, 464 women). Mean maximum diameter of the assessed STMs was 2.88 cm. Of 870 analyzed lesions ≤ 5 cm, 170 (19.54%) were classified as superficial and 700 (80.46%) as deep. The malignancy rate of all lesions ≤ 5 cm was at 22.41% (superficial: 23.53% / deep: 22.14%). The malignancy rate dropped to 16.49% (20.79% / 15.32%) when assessing lesions ≤ 3 cm (p = 0.007) and to 15.0% (18.18% / 13.79%) when assessing lesions ≤ 2 cm (p = 0.006). Overall, lipoma was the most common benign lesion of superficial STMs (29.41%) and tenosynovial giant cell tumor was the most common benign lesion of deep STMs (23.29%). Undifferentiated pleomorphic sarcoma was the most common malignant diagnosis among both, superficial (5.29%) and deep (3.57%) STMs. Conclusions The rate of malignancy decreased significantly with tumor size in both, superficial and deep STMs. The distribution of entities was different between superficial and deep STMs, yet there was no significant difference found in the malignancy rate.

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Successful outcome of Langerhans cell histiocytosis complicated by therapy-related myelodysplasia and acute myeloid leukemia: a case report

Cases Journal ◽

10.1186/1757-1626-1-101 ◽

2008 ◽

Vol 1 (1) ◽

Cited By ~ 2

Author(s):

Khalid A Al-Anazi ◽

Abdulrahman Alshehri ◽

Hazza A Al-Zahrani ◽

Fahad I Al-Mohareb ◽

Irfan Maghfoor ◽

...

Keyword(s):

Acute Myeloid Leukemia ◽

Case Report ◽

Myeloid Leukemia ◽

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Successful Outcome ◽

Acute Myeloid

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Chalastospora gossypii in a Maine Coon cat: case report and literature review

Journal of Veterinary Diagnostic Investigation ◽

10.1177/10406387211022298 ◽

2021 ◽

pp. 104063872110222

Author(s):

Samantha M. Norris ◽

Paula A. Schaffer ◽

Noah B. Bander

Keyword(s):

Soft Tissue ◽

Needle Aspiration ◽

Tissue Mass ◽

Large Numbers ◽

Formalin Fixed Paraffin ◽

Formalin Fixed Paraffin Embedded ◽

Soft Tissue Masses ◽

Subcutaneous Mass ◽

The Right ◽

A Minor

A 15-y-old castrated male Maine Coon cat was evaluated for an ulcerated soft tissue mass on the right hindlimb that had been observed for 4 mo and had grown rapidly. A 3 × 3 cm soft, raised, amorphous, and ulcerated subcutaneous mass was observed on the lateral right metatarsus. In-house cytology via fine-needle aspiration was nondiagnostic. Incisional biopsy of the mass and further staging was declined, and amputation was elected. The amputated limb was submitted for histopathology, which revealed severe chronic nodular granulomatous dermatitis and multifocal granulomatous popliteal lymphadenitis with large numbers of intralesional fungal hyphae. Fungal PCR and sequencing on formalin-fixed, paraffin-embedded tissue identified Chalastospora gossypii. No adjunctive therapy was elected at the time. The patient has done well clinically 1 y post-operatively. C. gossypii is a rare microfungus found worldwide and is considered a minor pathogen of several plants. To our knowledge, infection by this fungus has not been reported previously in veterinary species. Features in our case are comparable to other mycotic infections. Nodular granulomatous mycotic dermatitis and cellulitis, although uncommon, should be a differential for soft tissue masses in veterinary species; C. gossypii is a novel isolate.

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Color doppler ultrasonography of soft-tissue masses

Acta Radiologica ◽

10.1080/02841859809172457 ◽

1998 ◽

Vol 39 (4) ◽

pp. 421-426 ◽

Cited By ~ 17

Author(s):

R. Lagalla ◽

A. Iovane ◽

G. Caruso ◽

M. Lo Bello ◽

L. E. Derchi

Keyword(s):

Soft Tissue ◽

Doppler Ultrasonography ◽

Color Doppler ◽

Soft Tissue Tumors ◽

Color Doppler Ultrasonography ◽

Tissue Mass ◽

Vascular Impedance ◽

The Us ◽

Soft Tissue Masses ◽

Malignant Lesions

Purpose: To evaluate the capability of color Doppler ultrasonography to differentiate between benign and malignant soft-tissue tumors. Material and Methods: We reviewed the ultrasonographic (US) and color Doppler (CD) findings in 46 consecutive patients with a palpable periskeletal mass. The presence of 3 or more vascular hila and of tortuous and irregular internal vessels within the lesions was considered an indication of malignancy. The CD diagnosis was compared with that obtained at US alone. Results: The sensitivity and specificity of CD were respectively 85% and 92%; these values were higher than those obtained at US alone, respectively 75% and 50%. Arteriovenous malformations presented as lesions with large internal vessels that had low vascular impedance and were easily diagnosed. The waveform patterns within solid tumors were not specific. Conclusion: At present, US is commonly employed to confirm the presence of a suspected soft-tissue mass, to locate it accurately, and to indicate its nature. CD findings enhance the role of the US technique in such lesions. The combined use of US and CD can allow the differentiation of benign from malignant lesions, and thus provide a better basis for treatment.

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