Synthesis, Spectroscopic Characterization and Biological Activities of Transition Metal Complexes Derived from a Tridentate Schiff Base

A new series of Cu (II), Ni (II), Co (II) and Zn (II) complexes have been synthesized from the Schiff base derived from 4-hydroxy-3-methoxybenzylidine-4-aminoantipyrine and 2-aminophenol. The structural features have been determined from their elemental analysis, magnetic susceptibility, molar conductance, Mass, IR, UV-Vis,1H-NMR,13C-NMR and ESR spectral studies. The redox behavior of the copper complex has been studied by cyclic voltammetry. The data confirm that the complexes have composition of ML2type. The electronic absorption spectral data of the complexes propose an octahedral geometry around the central metal ion. All the metal complexes with DNA structure were guided by the presence of inter-molecular C–HO and C–HN hydrogen bonds. The biological activity of the synthesized compounds were tested against the bacterial species such asBacillus subtilis, Staphylococcus aureus, Proteus vulgarisand fungal species such asCandida albicansby thewell-diffusionmethod.

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Synthesis, Spectroscopic Characterization, and Biological Activities of Metal Complexes of 4-((4-Chlorophenyl)diazenyl)-2-((p-tolylimino)methyl)phenol

Journal of Chemistry ◽

10.1155/2013/724163 ◽

2013 ◽

Vol 2013 ◽

pp. 1-12

Author(s):

C. Anitha ◽

C. D. Sheela ◽

P. Tharmaraj ◽

V. V. Hema

Keyword(s):

Schiff Base ◽

Second Harmonic ◽

Biological Activities ◽

Potassium Dihydrogen Phosphate ◽

Spectroscopic Characterization ◽

Structural Features ◽

Schiff Base Complexes ◽

Spectral Studies ◽

Planar Geometry ◽

Dihydrogen Phosphate

Azo Schiff base complexes of VO(II), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) have been synthesized from 4-((4-chlorophenyl)diazenyl)-2-((p-tolylimino)methyl)phenol (CDTMP). The nature of bonding and the structural features of the complexes have been deduced from elemental analysis, molar conductance, magnetic susceptibility measurements, IR, UV-Vis,1H-NMR, EPR, mass, SEM, and fluorescence spectral studies. Spectroscopic and other analytical studies reveal square-planar geometry for copper, square-pyramidal geometry for oxovanadium, and octahedral geometry for other complexes. The EPR spectra of copper(II) complex in DMSO at 300 K and 77 K were recorded, and its salient features are reported. Antimicrobial studies against several microorganisms indicate that the complexes are more potent bactericides and fungicides than the ligand. The electrochemical behavior of the copper(II) complex was studied by cyclic voltammetry. All the synthesized compounds can serve as potential photoactive materials as indicated from their characteristic fluorescence properties. The second harmonic conversion efficiency of the synthesized azo Schiff base was found to be higher than that of urea and KDP (potassium dihydrogen phosphate). SEM image of copper(II) complex implies the crystalline state and surface morphology of the complex.

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Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand

E-Journal of Chemistry ◽

10.1155/2012/291850 ◽

2012 ◽

Vol 9 (1) ◽

pp. 389-400 ◽

Cited By ~ 8

Author(s):

B. Anupama ◽

M. Padmaja ◽

C. Gyana Kumari

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Schiff Base Ligand ◽

Metal Ion ◽

Spectral Studies ◽

Significant Activity ◽

Central Metal ◽

Binding Studies

A new series of transition metal complexes of Cu(II),Ni(II),Co(II), Zn(II) and VO(IV) have been synthesized from the Schiff base ligand (L) derived from 4-amino antipyrine and 5- bromo salicylaldehyde. The structural features of Schiff base and metal complexes were determined from their elemental analyses, thermogravimetric studies, magneticsusceptibility, molar conductivity, ESI-Mass, IR, UV-VIS,1H NMR and ESR spectral studies. The data show that the complexes have composition of ML2type. The UV-VIS, magnetic susceptibility and ESR spectral data suggest an octahedral geometry around the central metal ion. Biological screening of the complexes reveals that the Schiff base transition metal complexes show significant activity against microorganisms. Binding of Co(II) complex with calf thymus DNA (CT DNA) was studied by spectral methods.

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Synthesis, Structural Studies of Some New Transition Metals Complexes of Semicarbazide hydro chloride Schiff Base Derivatives

Baghdad Science Journal ◽

10.21123/bsj.10.3.583-596 ◽

2013 ◽

Vol 10 (3) ◽

pp. 583-596 ◽

Cited By ~ 1

Author(s):

Baghdad Science Journal

Keyword(s):

Magnetic Susceptibility ◽

Schiff Base ◽

Metal Complexes ◽

Structural Features ◽

Heat Of Formation ◽

Spectral Studies ◽

Central Metal ◽

Tetrahedral Geometry ◽

L1 And L2 ◽

Hydro Chloride

A new series of transition metal complexes of Cu(II), Ni(II), Co(II) and Fe(III) have been synthesized from the Schiff base (L1) and (L2) derived from Semicarbazide hydro chloride and 4-chlorobenzaldehyde or 4-bromobenzaldehyde. The structural features have been arrived from their elemental analyses, magnetic susceptibility, molar conductivity, IR, UV-Vis. and 1H NMR spectral studies. The data show that the complexes have composition of [M(L)2](NO3)2 and [Fe(L)2 (NO3)2](NO3) where the M=Co(II),Ni(II) and Cu(II) ;L=L1and L2 type. The magnetic susceptibility and UV-Vis spectral data of the complexes suggest a square planer geometry for Co(II) and Cu(II) but Fe(III) octahedral geometry and Ni(II) tetrahedral geometry around the central metal ion.Hyper Chem-6 program has been used to predict structure geometries of compounds in gas phase .The electrostatic potential of the free ligands were calculated to investigate the reactive sites of the molecules .The heat of formation(?Hf ?) and binding energy(?Eb) at 298K for the free ligands and its metal complexes were calculated by using PM3 method.

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Designing, synthesis and spectral characterization of Schiff base transition metal complexes: DNA cleavage and antimicrobial activity studies

Journal of the Serbian Chemical Society ◽

10.2298/jsc0811063r ◽

2008 ◽

Vol 73 (11) ◽

pp. 1063-1071 ◽

Cited By ~ 22

Author(s):

N. Raman ◽

Syed Ali ◽

Dhaveethu Raja

Keyword(s):

Magnetic Susceptibility ◽

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Spectral Data ◽

Transition Metal Complexes ◽

Metal Ion ◽

Spectral Studies ◽

Central Metal ◽

Elemental Analyses

A new series of transition metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been designed and synthesized using a Schiff base (L) derived from 4-aminoantipyrine, benzaldehyde and o-phenylenediamine. The structural features were derived from their elemental analyses, magnetic susceptibility and molar conductivity, as well as from mass, IR, UV-Vis, 1H-NMR and ESR spectral studies. The FAB mass spectral data and elemental analyses showed that the complexes had a composition of the ML type. The UV-Vis and ESR spectral data of the complexes suggested a square-planar geometry around the central metal ion. The magnetic susceptibility values of the complexes indicated that they were monomeric in nature. Antimicrobial screening tests were also performed against four bacteria, viz. Salmonella typhi, Staphylococcus aureus, Escherichia coli, and Bacillus subtilis and three fungi, viz. Aspergillus niger, Aspergillus flavus and Rhizoctonia bataicola. These data gave good results in the presence of metal ion in the ligand system. The nuclease activity of the above metal complexes shows that only the copper complex cleaves CT DNA in the presence of an oxidant.

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SYNTHESIS, MOLLUSCICIDALAND ANTIMICROBIAL POTENTIALITIES OF IRON TRIAD MONONUCLEAR METAL COMPLEXES INCORPORATING TRIDENTATE ASYMMETRICAL SCHIFF BASE LIGANDS CONTAINING SOFT SULFUR COORDINATING ATOM

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i2.36481 ◽

2019 ◽

pp. 103-113

Author(s):

AMAL M ALOSAIMI ◽

INES EL MANNOUBI ◽

SAMI A ZABIN

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Metal Ion ◽

Lethal Dose ◽

Analytical Techniques ◽

Central Metal ◽

Schiff Base Ligands ◽

Molluscicidal Activity

Objective: This work aimed at synthesizing tridentates asymmetrical Schiff base ligands containing sulfur atom and using them for preparing metal complexes with the iron triad metals. The prepared compounds were assayed in vitro for antimicrobial potential and in vivo molluscicidal activity. Methods: The unsymmetrical tridentate Schiff bases (SL1, SL2, and SL3) were prepared using 2-aminothiophenol as primary amine and condensed with 2-carboxybenzaldehyde, 2-hydroxy-1-naphthaldehyde, and 7-formyl-8-hydroxyquinoline. These ligands were used in preparing metal complexes with iron triad metals. The synthesized Schiff base ligands and their corresponding metal complexes were characterized and their proposed structures were confirmed using different physical and spectroscopic analytical techniques. All ligands and their corresponding metal complexes were assayed against different bacterial and fungal strains using the agar disk-diffusion technique. The molluscicidal activity was performed according to the standard reported methods as cited in the literature and by observing the toxicity and lethal dose according to the WHO guidelines. Results: The synthesized ligands behave as tridentate (NOS) ligands and form mononuclear complexes with the general formula [M(SL)2] with an octahedral geometry around the central metal ion. Metal complexes were non-electrolytic in nature. The in vitro antibacterial and antifungal examination results showed weak activity of the ligands, and there was enhanced activity with the complexes. The in vivo molluscicidal activity of the tested compounds showed good activity. Conclusion: The targeted compounds were prepared successfully, characterized, and showed some biological activity but lower than the standard reference drugs.

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Synthesis and Spectral Studies of 4,4′-(Hydrazine-1,2-diylidenedimethylylidene)-bis-(2- methoxyphenol) and Its Transition Metal Complexes with Promising Biological Activities

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22703 ◽

2020 ◽

Vol 32 (7) ◽

pp. 1768-1772

Author(s):

Anita Rani ◽

Manoj Kumar ◽

Hardeep Singh Tuli ◽

Zahoor Abbas ◽

Vinit Prakash

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Schiff Base Ligand ◽

Biological Activities ◽

Condensation Reaction ◽

Analytical Techniques ◽

Spectral Studies

The study describes the synthesis, characterization and biological activity of a novel Schiff base ligand and its transition metal complexes. The Schiff base ligand was obtained by a condensation reaction between 4-hydroxy-3-methoxybenzaldehyde (p-vanillin) and hydrazine hydrate using ethanol as solvent. A new series of Ni(II) and Fe(III) complexes were also derived by reaction of prepared Schiff base ligand with NiCl2 and FeCl3. Both the ligand and its metal complexes were characterized by solubility, melting point and elemental analysis. These compounds were further identified by analytical techniques, FTIR, NMR and mass spectrometry. The ligand and its transition metal complexes were also subjected to in vitro biological activities i.e. antimicrobial, antiangiogenic and DNA photo cleavage. For antimicrobial activity compounds were tested against two strains of bacteria and two strains of fungi. Different concentrations of prepared compounds were treated with fertilized chicken eggs and plasmid DNA to find out antiangiogenic and DNA photocleavage activity, respectively.

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Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Nickel and Copper Complexes of Bis(thiosemicrbazone)

Bioinorganic Chemistry and Applications ◽

10.1155/2007/51483 ◽

2007 ◽

Vol 2007 ◽

pp. 1-7 ◽

Cited By ~ 27

Author(s):

Sulekh Chandra ◽

Smriti Raizada ◽

Monika Tyagi ◽

Archana Gautam

Keyword(s):

Metal Complexes ◽

Metal Ion ◽

Copper Complexes ◽

Free Ligand ◽

Antimicrobial Properties ◽

Molar Conductance ◽

Spectral Studies ◽

Central Metal ◽

Antimicrobial Studies

A series of metal complexes of Cu(II) and Ni(II) having the general composition[M(L)X2]with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

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Synthesis, Characterization, Antimicrobial, DNA Cleavage, andIn VitroCytotoxic Studies of Some Metal Complexes of Schiff Base Ligand Derived from Thiazole and Quinoline Moiety

Bioinorganic Chemistry and Applications ◽

10.1155/2014/314963 ◽

2014 ◽

Vol 2014 ◽

pp. 1-17 ◽

Cited By ~ 21

Author(s):

Nagesh Gunvanthrao Yernale ◽

Mruthyunjayaswamy Bennikallu Hire Mathada

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Schiff Base Ligand ◽

Dna Cleavage ◽

Biological Activities ◽

Artemia Salina ◽

Spectral Studies ◽

Antibacterial And Antifungal Activities ◽

Pyramidal Geometry

A novel Schiff base ligandN-(4-phenylthiazol-2yl)-2-((2-thiaxo-1,2-dihydroquinolin-3-yl)methylene)hydrazinecarboxamide(L)obtained by the condensation ofN-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 2-thioxo-1,2-dihydroquinoline-3-carbaldehyde and its newly synthesized Cu(II), Co(II), Ni(II), and Zn(II) complexes have been characterized by elemental analysis and various spectral studies like FT-IR,1H NMR, ESI mass, UV-Visible, ESR, TGA/DTA, and powder X-ray diffraction studies. The Schiff base ligand(L)behaves as tridentate ONS donor and forms the complexes of type [ML(Cl)2] with square pyramidal geometry. The Schiff base ligand(L)and its metal complexes have been screenedin vitrofor their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activity of ligand and its metal complexes were studied using plasmid DNA pBR322 as a target molecule by gel electrophoresis method. The brine shrimp bioassay was also carried out to study thein vitrocytotoxicity properties for the ligand and its metal complexes againstArtemia salina. The results showed that the biological activities of the ligand were found to be increased on complexation.

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Synthesis, characterization, thermal, theoretical and antimicrobial studies of Schiff base ligand and its Co(II) and Cu(II) complexes

Journal of the Serbian Chemical Society ◽

10.2298/jsc181128049v ◽

2020 ◽

Vol 85 (2) ◽

pp. 215-225 ◽

Cited By ~ 1

Author(s):

Palaniswamy Venkittapuram ◽

Mahalakshmi Dhandapani ◽

Jonekirubavathy Suyambulingam ◽

Chitra Subramanian

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Schiff Base Ligand ◽

Bacterial Species ◽

Thermal Analyses ◽

Fungal Species ◽

Basis Sets ◽

Chloride Salt ◽

Antimicrobial Studies ◽

Ft Ir

A Schiff base ligand L was synthesized by condensation of 1,2-diaminoethane with creatinine. The reaction of the ligand with metal chloride salt gives Co(II) and Cu(II) complexes. The synthesized ligand and its metal complexes were characterized by elemental analysis, FT-IR, NMR, UV?Vis, conductivity and magnetic susceptibility measurements as well as thermal analyses. Based on spectral data, tetrahedral geometries have been proposed for the Co(II) and Cu(II) complexes. The molar conductivity data show that the complexes are non-electrolytic in nature. In DFT studies, the geometry of the Schiff base ligand and its Co(II) and Cu(II) complexes were fully optimized using the B3LYP functional together with 6-31g(d,p) and LANL2DZ basis sets. The ligand and its metal complexes were tested against four bacterial species and two fungal species. The results revealed that the metal complexes are more potent against the microbes than the parent ligand.

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