scholarly journals Functional Dyspepsia in Review: Pathophysiology and Challenges in the Diagnosis and Management due to Coexisting Gastroesophageal Reflux Disease and Irritable Bowel Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Shadi S. Yarandi ◽  
Jennifer Christie
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Dyspepsia ◽  
Reflux Disease ◽  
Epigastric Pain ◽  
Diagnostic Testing ◽  
Treatment Strategies ◽  
Treatment Modalities ◽  
Main Symptom ◽  
Early Satiation ◽  
Irritable Bowel

Functional dyspepsia is a common disorder which imposes significant diagnostic and treatment challenges for patients and physicians. The most recent update of the diagnostic criteria subdivides functional dyspepsia into two subcategories based on the main symptom of epigastric pain or postmeal fullness. As we discuss in this review, several studies have shown significant overlap in symptoms and pathophysiology between functional dyspepsia, irritable bowel syndrome, and the spectrum of reflux disorders. This overlap in symptoms can be informative in helping us to understand the underlying pathophysiology, diagnostic approaches, and treatment strategies. The addition of diagnostic testing such as pH impedance manometry of the distal esophagus to the current common diagnostic tests might be helpful in distinguishing between functional dyspepsia and reflux disease. Importantly, various treatment modalities may be more effective than others if the main symptom is burning rather than pain or postmeal fullness rather than early satiation.

Combined detection of inorganic syndromes of the gastrointestinal tract and their differential diagnosis.

2021 ◽  
Vol 2021 (2) ◽  
pp. 68-71
Author(s):  
R.I. Khalafova ◽  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Differential Diagnosis ◽  
Gastrointestinal Tract ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Functional Dyspepsia ◽  
Military Personnel ◽  
Reflux Disease ◽  
Irritable Bowel ◽  
Combined Detection

To study the frequency of detection of combinations of the main syndromes of the gastrointestinal tract (GIT) and their differential diagnosis, consisting of irritable bowel syndrome (IBS), syndrome of functional dyspepsia (SFD), chronic idiopathic dyspepsia (CIT) and gastroesophageal reflux disease (GERD). The main gastrointestinal syndromes are quite often detected among different groups of military personnel and members of their families. ES plays an important role in their formation. International recommendations allow anamnestic diagnosis of each of the syndromes in separately and in combination with each other. The medical appealability of patients depends on the severity of the symptoms of the syndromes, it is most pronounced when they are combined.

scholarly journals Functional Dyspepsia: Subtypes, Risk Factors, and Overlap with Irritable Bowel Syndrome in a Population of African Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Sylvester Chuks Nwokediuko ◽  
Uchenna Ijoma ◽  
Olive Obienu
Keyword(s):  
Risk Factors ◽  
Irritable Bowel Syndrome ◽  
Functional Dyspepsia ◽  
Distress Syndrome ◽  
Epigastric Pain ◽  
Pain Syndrome ◽  
Postprandial Distress Syndrome ◽  
Epigastric Pain Syndrome ◽  
Irritable Bowel ◽  
African Patients

Background. Functional dyspepsia is the prototype functional gastrointestinal disorder. This study was designed to determine its prevalence, subtypes, and risk factors associated with the subtypes.Method. Patients with upper gastrointestinal symptoms who presented for endoscopy were administered a questionnaire containing the functional dyspepsia and irritable bowel syndrome modules of the Rome III diagnostic criteria.Results. Of 192 patients who had functional dyspepsia, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes accounted for 79.2%, 62.5%, and 50%, respectively. Multivariate analysis of the risk factors showed that independent predictors of postprandial distress syndrome were alcohol and irritable bowel syndrome while irritable bowel syndrome was independent predictor of epigastric pain syndrome. Alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs were independent predictors of cooccurrence of postprandial distress syndrome and epigastric pain syndrome.Conclusion. Functional dyspepsia accounts for 62.5% of dyspepsia in a population of black African patients. Regarding symptomatology, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes account for 79.2%, 62.5%, and 50%, respectively. Risk factors for functional dyspepsia are irritable bowel syndrome, alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs.

scholarly journals Prevalence of Irritable Bowel Syndrome, Functional Dyspepsia and their Overlap in Bulgaria: a Population-Based Study

2020 ◽  
Vol 29 (3) ◽  
pp. 329-338
Author(s):  
Radislav Nakov ◽  
Desislava Dimitrova-Yurukova ◽  
Violeta Snegarova ◽  
Milena Uzunova ◽  
Ivan Lyutakov ◽  
...  
Keyword(s):  
Risk Factors ◽  
Irritable Bowel Syndrome ◽  
Functional Dyspepsia ◽  
Epigastric Pain ◽  
Sexual Problems ◽  
Milk Intolerance ◽  
Factors Associated ◽  
Epigastric Pain Syndrome ◽  
Bulgarian Population ◽  
Irritable Bowel

Aims: We aimed to evaluate the prevalence of irritable bowel syndrome (IBS), functional dyspepsia (FD), and their overlap syndrome (OS) in the Bulgarian population and to assess the risk factors associated with these disorders. Methods: We sent an internet-based survey to Bulgarian adults. The survey collected data on socio- demographic, behavioral and lifestyle characteristics, and diagnostic questions following the Rome IV criteria to assess IBS, FD and their overlap occurrence. Results: Data was collected from 1,896 individuals (mean age = 35.5 years, 18-65, SD=11.7), 73.1% females. The prevalence of IBS was 20% (14% were with predominant constipation, 32% with predominant diarrhea, 52% had IBS with mixed bowel habits, and 2% unclassified IBS). Gender (p=0.005), age (p<0.001), marital status (p=0.009), occupation (p=0.001), alcohol consumption (p=0.013), sexual problems (p<0.001), FD (p<0.001), and milk intolerance (p<0.001) were significantly associated with IBS. Females (p=0.032; OR: 1.50), patients with FD (p<0.001; OR: 104.98), sexual problems (p= 0.001; ОR: 1.55 ), and milk intolerance (p<0.001; OR: 2.22) are at a higher risk of having IBS. The prevalence of FD was 12.7% (39% had postprandial distress syndrome, 33% epigastric pain syndrome, and 28% had the overlapping variant). Patients with IBS (p<0.001; OR: 127.88) and milk intolerance (p<0.001) were significantly associated with FD prevalence. The prevalence of OS was 11.7%. Gender (p=0.013), milk intolerance (p<0.001, OR: 1.65), urinary (p=0.035) and sexual problems (p<0.001, ОR: 1.80) were associated with OS prevalence. Conclusion: This is the first study to estimate the prevalence of IBS, FD, and their OS and assess the behavioral and demographic risk factors associated with these disorders in the Bulgarian population. Our results are valuable in filling in the epidemiological data gap regarding IBS, FD, and OS in Eastern Europe.

scholarly journals Evaluation of the association between duodenal eosinophil counts, functional dyspepsia, symptomatic erosive GERD and other variables: A retrospective multi-ethnic Malaysian study.

2021 ◽  
Author(s):  
Sundramoorthy Mahendra Raj ◽  
Sarala Ravindran ◽  
Manreesha Kaur ◽  
Michelle Clare Braganza ◽  
Anil Philip Kunnath
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Dyspepsia ◽  
Reflux Disease ◽  
Gallstone Disease ◽  
Gall Stone ◽  
Primary Diagnosis ◽  
Stone Disease ◽  
Relative Strength ◽  
Irritable Bowel ◽  
Eosinophil Counts

Abstract Background: Duodenal eosinophilia is postulated to play a key role in the pathogenesis of functional dyspepsia. Our objective was to evaluate the relative strength of the associations, between duodenal eosinophil counts functional dyspepsia, symptomatic erosive gastroesophageal reflux disease (GERD), the presence of co-morbidities and a number of other variables.Methods: Eosinophil counts of archived endoscopic duodenal biopsies of 289 subjects were determined by a pathologist blinded to the clinical data. Duodenal eosinophilia was defined by a count of more than 15 per 5 high power fields. Clinical charts were reviewed by a gastroenterologist blinded to the histology review. Results: The primary diagnosis was functional dyspepsia (undifferentiated by subtypes) in 45, symptomatic erosive GERD in 29, gall stone disease in 17, irritable bowel syndrome in 23 and an alternative or undetermined diagnosis in 175 subjects respectively. On logistic regression analyses, eosinophil counts were associated with symptomatic erosive GERD (OR 1.03, 95% CI 1.00 - 1.05; p=0.035) but not functional dyspepsia. Pre-defined duodenal eosinophilia was associated with symptomatic erosive gastro-oesophageal reflux disease (OR 3.13, 95% CI 1.11 - 8.80; p=0.030), the presence of co-morbidities (OR 2.11, 95% CI 1.16 - 3.84; p=0.014), Chinese (compared to Malay and Indian) ethnicity and lower age but not with either functional dyspepsia, irritable bowel syndrome, gallstone disease, Helicobacter pylori infection or gender. Conclusion: Duodenal eosinophilia was associated with symptomatic erosive GERD, the presence of co-morbidities and Chinese ethnicity but not with undifferentiated functional dyspepsia. Taken in conjunction with other studies, these findings support the hypothesis that subsets of GERD and functional dyspepsia may be part of a disease spectrum characterised by duodenal eosinophilia.

scholarly journals Impact of Coexisting Irritable Bowel Syndrome and Non-erosive Reflux Disease on Postprandial Abdominal Fullness and Sleep Disorders in Functional Dyspepsia

2013 ◽  
Vol 80 (5) ◽  
pp. 362-370 ◽  
Author(s):  
Seiji Futagami ◽  
Hiroshi Yamawaki ◽  
Mayumi Shimpuku ◽  
Nikki Izumi ◽  
Taiga Wakabayashi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Sleep Disorders ◽  
Functional Dyspepsia ◽  
Reflux Disease ◽  
Irritable Bowel ◽  
Abdominal Fullness
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