miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1
2013 ◽
Vol 2013
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pp. 1-8
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Keyword(s):
MicroRNAs (miRNAs) have been implied to play crucial roles for epithelial-to-mesenchymal transition (EMT) of non-small-cell lung cancer cells (NSCLC cells). Here we found that the expression of miR-149, downregulated in lung cancer, was inversely correlated with invasive capability and the EMT phenotype of NSCLC cells. miR-149 inhibited EMT in NSCLC cells. Furthermore, we demonstrated that miR-149 directly targeted Forkhead box M1 (FOXM1), and FOXM1 was involved in the EMT induced by TGF-β1 in A549 cells. Overexpression of FOXM1 restored EMT process inhibited by miR-149. Our work suggested that miR-149 might be an EMT suppressor in NSCLC cells.
2021 ◽
Vol 38
(3)
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pp. 294-300
2014 ◽
Vol 20
(2 Supplement)
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pp. A30-A30
2014 ◽
Vol 20
(2 Supplement)
◽
pp. A05-A05
2013 ◽
Vol 380
(1-2)
◽
pp. 277-282
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2016 ◽
Vol 50
(4)
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pp. 583-590
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