scholarly journals pH Responsive Self-Assembly of Cucurbit[7]urils and Polystyrene-Block-Polyvinylpyridine Micelles for Hydrophobic Drug Delivery

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Basem A. Moosa ◽  
Afnan Mashat ◽  
Wengang Li ◽  
Karim Fhayli ◽  
Niveen M. Khashab
Keyword(s):  
Drug Delivery ◽  
Aqueous Solution ◽  
Self Assembly ◽  
Room Temperature ◽  
Water Soluble ◽  
Hydrophobic Drug ◽  
Ph Responsive ◽  
Ph Values ◽  
Neutral Ph ◽  
Release Study

Polystyrene-block-polyvinylpyridine (PS-b-P4VP) polypseudorotaxanes with cucurbit[7]urils (CB[7]) were prepared from water soluble PS-b-P4VPH+polymer and CB[7] in aqueous solution at room temperature. At acidic and neutral pH, the pyridinium block of PS-b-P4VP is protonated (PS-b-P4VPH+) pushing CB[7] to preferably host the P4VP block. At basic pH (pH 8), P4VP is not charged and thus is not able to strongly complex CB[7]. This phenomenon was verified further by monitoring the release of pyrene, a hydrophobic cargo model, from a PS-b-P4VPH+/CB[7] micellar membrane. Release study of UV active pyrene from the membrane at different pH values revealed that the system is only operational under basic conditions and that the host-guest interaction of CB[7] with P4VPH+significantly slows down cargo release.

scholarly journals Self-assembly induced luminescence of Eu3+-complexes and application in bioimaging

2021 ◽  
Author(s):  
Ping-Ru Su ◽  
Tao Wang ◽  
Pan-Pan Zhou ◽  
Xiao-Xi Yang ◽  
Xiao-Xia Feng ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Rare Earth ◽  
Luminescence Intensity ◽  
Self Assembly ◽  
Room Temperature ◽  
Molecular Motion ◽  
Proof Of Concept ◽  
Room Temperature Phosphorescence ◽  
New Strategy ◽  
Size Controlled

Abstract Design and engineering of highly efficient emitting materials with assembly-induced luminescence, such as room temperature phosphorescence (RTP) and aggregation-induced emission (AIE), have stimulated extensive efforts. Here, we propose a new strategy to obtain size-controlled Eu3+-complex nanoparticles (Eu-NPs) with self-assembly induced luminescence (SAIL) characteristics without encapsulation or hybridization. Compared with previous RTP or AIE materials, the SAIL phenomena of increased luminescence intensity and lifetime in aqueous solution for the proposed Eu-NPs are due to the combined effect of self-assembly in confining the molecular motion and shielding the water quenching. As a proof of concept, we also show that this system can be further applied in bioimaging, temperature measurement and HClO sensing. The SAIL activity of the rare-earth (RE) system proposed here offers a further step forward on the roadmap for the development of RE light conversion systems and their integration in bioimaging and therapy applications.

A water-soluble biphen[3]arene: synthesis, host–guest complexation, and application in controllable self-assembly and controlled release

2015 ◽  
Vol 51 (20) ◽  
pp. 4188-4191 ◽  
Author(s):  
Jiong Zhou ◽  
Guocan Yu ◽  
Li Shao ◽  
Bin Hua ◽  
Feihe Huang
Keyword(s):  
Controlled Release ◽  
Self Assembly ◽  
Water Soluble ◽  
Ammonium Salts ◽  
Ph Responsive ◽  
Recognition Motif

The first water-soluble biphen[3]arene was synthesized. Its pH-responsive host–guest complexation with secondary ammonium salts in water was investigated. This novel recognition motif was further used in controllable self-assembly and controlled release.

Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery

AIChE Journal ◽  
2008 ◽  
Vol 54 (11) ◽  
pp. 2979-2989 ◽  
Author(s):  
Youqing Shen ◽  
Yihong Zhan ◽  
Jianbin Tang ◽  
Peisheng Xu ◽  
Patrick A. Johnson ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Polymer Brush ◽  
Cancer Drug ◽  
Ph Responsive ◽  
Cancer Drug Delivery

A Tunable pH-Responsive Nanomaterials for Cancer Delivery

2013 ◽  
Vol 750-752 ◽  
pp. 1476-1479 ◽  
Author(s):  
Bin Liu ◽  
Guan Hui Gao ◽  
Peng Liu ◽  
Hu Qiang Yi ◽  
Wei Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Potential Application ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Positive Potential ◽  
Ph Values ◽  
Drugs In Blood ◽  
Poly Ethylene

In this paper, we successfully designed a pH-responsive micelles based on hybrid polypeptide copolymers of poly (L-lysine-4-Azepan-1-yl-butyric)-b-poly (ethylene glycol)-b-poly (L-lysine-Diisopropylamide)-b-poly (L-leucine) (PLL(A)-PEG-PLL(B)-PLLeu) for efficient drug delivery. This pH-responsive nanoparticles were able to response to different pH values (pH=6.8 and 5.5). In vitro, these nanoparticles exhibited a stable and evenly distributed approximately 51 nm, a slightly positive potential about 10.3 mv at pH 7.4, which were crucial for the circulation of drugs in blood. While size and potential were about 130 nm and 34.7 mv at pH 6.8, which were good for drugs in membrane. Furthermore, the loading capability of DOX was up to 11.3%, and the pH-responsive release efficiency reached to 68.3% at pH 5.5. The results indicated that these micelles had huge potential application in cancer delivery.

scholarly journals Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31581-31587 ◽  
Author(s):  
Lin Wang ◽  
Xuefeng Shi ◽  
Jian Zhang ◽  
Yuejun Zhu ◽  
Jinben Wang
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Ph Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembled

Supramolecular hydrogel, AGC16/NTS, was used to encapsulate hydrophobic drug curcumin (Cur), constructing a pH-responsive drug delivery system; the uptake of released Cur by cancer cells also occurred.

Synthesis and Electrochemical, Photophysical, and Self-Assembly Studies on Water-Soluble pH-Responsive Alkynylplatinum(II) Terpyridine Complexes

2016 ◽  
Vol 55 (9) ◽  
pp. 4650-4663 ◽  
Author(s):  
Clive Yik-Sham Chung ◽  
Steve Po-Yam Li ◽  
Kenneth Kam-Wing Lo ◽  
Vivian Wing-Wah Yam
Keyword(s):  
Self Assembly ◽  
Water Soluble ◽  
Ph Responsive

Improved in vivo tumor therapy via host–guest complexation

2016 ◽  
Vol 4 (15) ◽  
pp. 2691-2696 ◽  
Author(s):  
Yong Yao ◽  
Yang Wang ◽  
Ruibo Zhao ◽  
Li Shao ◽  
Ruikang Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Intracellular Ph ◽  
Tumor Therapy ◽  
Controlled Drug Delivery ◽  
Water Soluble ◽  
Ph Responsive ◽  
Mesoporous Nanoparticles

A decomposable and intracellular pH-responsive drug delivery system by immobilizing a water-soluble pillar[5]arene onto hollow mesoporous nanoparticles through host–guest complexation was successfully prepared and its application in controlled drug delivery in vitro and in vivo was also investigated.

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