scholarly journals Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31581-31587 ◽  
Author(s):  
Lin Wang ◽  
Xuefeng Shi ◽  
Jian Zhang ◽  
Yuejun Zhu ◽  
Jinben Wang
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Ph Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembled

Supramolecular hydrogel, AGC16/NTS, was used to encapsulate hydrophobic drug curcumin (Cur), constructing a pH-responsive drug delivery system; the uptake of released Cur by cancer cells also occurred.

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

scholarly journals Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core

Nanomaterials ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 588 ◽  
Author(s):  
Xia Li ◽  
Manpreet Sambi ◽  
Alexandria DeCarlo ◽  
Sergey V. Burov ◽  
Roman Akasov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inner Core ◽  
Hydrophobic Drug ◽  
Alternating Copolymer ◽  
Smart Drug ◽  
Smart Drug Delivery

Engineering of a “smart” drug delivery system to specifically target tumour cells has been at the forefront of cancer research, having been engineered for safer, more efficient and effective use of chemotherapy for the treatment of cancer. However, selective targeting and choosing the right cancer surface biomarker are critical for a targeted treatment to work. Currently, the available delivery systems use a two-dimensional monolayer of cancer cells to test the efficacy of the drug delivery system, but designing a “smart” drug delivery system to be specific for a tumour in vivo and to penetrate the inner core remains a major design challenge. These challenges can be overcome by using a study model that integrates the three-dimensional aspect of a tumour in a culture system. Here, we tested the efficacy of a functionalized folic acid-conjugated amphiphilic alternating copolymer poly(styrene-alt-maleic anhydride) (FA-DABA-SMA) via a biodegradable linker 2,4-diaminobutyric acid (DABA) to specifically target and penetrate the inner core of three-dimensional avascular human pancreatic and breast tumour spheroids in culture. The copolymer was quantitatively analyzed for its hydrophobic drug encapsulation efficiency using three different chemical drug structures with different molecular weights. Their release profiles and tumour targeting properties at various concentrations and pH environments were also characterized. Using the anticancer drug curcumin and two standard clinical chemotherapeutic hydrophobic drugs, paclitaxel and 5-fluorouracil, we tested the ability of FA-DABA-SMA nanoparticles to encapsulate the differently sized drugs and deliver them to kill monolayer pancreatic cancer cells using the WST-1 cell proliferation assay. The findings of this study revealed that the functionalized folic acid-conjugated amphiphilic alternating copolymer shows unique properties as an active “smart” tumor-targeting drug delivery system with the ability to internalize hydrophobic drugs and release the chemotherapeutics for effective killing of cancer cells. The novelty of the study is the first to demonstrate a functionalized “smart” drug delivery system encapsulated with a hydrophobic drug effectively targeting and penetrating the inner core of pancreatic and breast cancer spheroids and reducing their volumes in a dose- and time-dependent manner.

Daunorubicin -TiO2 Nanocomposites As ‘smart' pH-Responsive Drug Delivery System,

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 3479-3479 ◽  
Author(s):  
Hai-jun Zhang ◽  
Bao-An Chen
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Human Leukemia ◽  
Dependent Manner ◽  
Ph Responsive ◽  
Tio2 Nps ◽  
Anti Tumor Activity

Abstract Abstract 3479 Daunorubicin (DNR) with a broad spectrum of anti-tumor activity is limited due to the serious side-effects in the clinical application. The aim of this study was to explore the novel pH-responsive drug delivery system (DDS) based on titanium dioxide (TiO2) nanoparticles (Nps) for its potential roles to enable more intelligently controlled release, enhance chemotherapeutic efficiency, and reduce the side-effects of DNR. DNR was loaded onto the TiO2 Nps by forming (six-membered chelate) complexes with transition metal Ti to contract DNR-TiO2 nanocomposites as DDS. The encapsulation efficiency and loading efficiency of DNR loaded TiO2 Nps were assessed and calculated as 65.46±6.82% and 20.63±3.55%, respectively.The DNR was released from the DDS much more rapidly at pH 5.0 and 6.0 than at pH 7.4. The release behavior is a desirable characteristic for tumor-targeted drug delivery. Most DNR will remain in the carrier for a considerable time period at normal physiological conditions (pH 7.4), indicating the potential for the prolonged DNR retention time in the blood circulation and thereby greatly reducing the side effects to the normal tissues. On the other hand, once the DNR loaded TiO2 Nps are taken up by tumor cells via endocytotic process, a faster release may occur at lower local pH, i.e, inside the endosome and lysosome of cancer cells ((pH 4.5∼6.5), leading to the significant improvement in cancer treatment efficacy. The DNR- TiO2 nanocomposites as DDS induced the remarkable improvement in the anti-tumor activity, which were demonstrated by the flow cytometry, MTT assay and nuclear DAPI staining. Furthermore, the possible signaling pathway was explored by Western blot. For instance, in human leukemia cells (K562 cells), our observations demonstrated that the DDS could obviously increase the intracellular concentration of DNR and enhance its potential anti-tumor efficiency through inducing apoptosis in a caspase-dependent manner, indicating that DNR-TiO2 nanocomposites could act as an efficient DDS importing DNR into target cancer cells. These findings revealed that such ‘smart' DNR delivery strategy represent a promising approach in hematologic malignancy therapy. Disclosures: No relevant conflicts of interest to declare.

scholarly journals pH-responsive mesoporous silica drug delivery system, its biocompatibility and co-adsorption/co-release of 5-Fluorouracil and Naproxen

2021 ◽  
pp. 150011
Author(s):  
Eva Benova ◽  
Virginie Hornebecq ◽  
Vladimír Zelenak ◽  
Veronika Huntosova ◽  
Miroslav Almasi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Co Adsorption ◽  
Ph Responsive

Design and Function of Engineered Protein Nanocages as a Drug Delivery System for Targeting Pancreatic Cancer Cells via Neuropilin-1

2015 ◽  
Vol 12 (5) ◽  
pp. 1422-1430 ◽  
Author(s):  
Masaharu Murata ◽  
Sayoko Narahara ◽  
Takahito Kawano ◽  
Nobuhito Hamano ◽  
Jing Shu Piao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pancreatic Cancer Cells ◽  
Neuropilin 1 ◽  
And Function

An Acid-Triggered Degradable and Fluorescent Nanoscale Drug Delivery System with Enhanced Cytotoxicity to Cancer Cells

2015 ◽  
Vol 16 (8) ◽  
pp. 2444-2454 ◽  
Author(s):  
Jinxia An ◽  
Xiaomei Dai ◽  
Zhongming Wu ◽  
Yu Zhao ◽  
Zhentan Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System

A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel

2008 ◽  
Vol 359 (1-2) ◽  
pp. 228-233 ◽  
Author(s):  
MaLing Gou ◽  
XingYi Li ◽  
Mei Dai ◽  
ChangYang Gong ◽  
XianHuo Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Biodegradable Nanoparticles

FA-PEG decorated MOF nanoparticles as a targeted drug delivery system for controlled release of an autophagy inhibitor

2018 ◽  
Vol 6 (10) ◽  
pp. 2582-2590 ◽  
Author(s):  
Zheqi Shi ◽  
Xuerui Chen ◽  
Li Zhang ◽  
Shiping Ding ◽  
Xu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Specific Targeting ◽  
Autophagy Inhibitor ◽  
Novel Drug Delivery System ◽  
Novel Drug ◽  
Targeted Drug Delivery System

A novel drug delivery system with pH-responsive release and specific targeting identification was developed to control the release of an autophagy inhibitor.

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