scholarly journals Active Component ofAntrodia cinnamomeaMycelia Targeting Head and Neck Cancer Initiating Cells through Exaggerated Autophagic Cell Death

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Ching-Wen Chang ◽  
Chien-Chih Chen ◽  
Meng-Ju Wu ◽  
Yu-Syuan Chen ◽  
Chin-Chu Chen ◽  
...  
Keyword(s):  
Cell Death ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Active Component ◽  
Alternative Therapy ◽  
Drug Candidate ◽  
Aldh Activity ◽  
Drug Candidates

Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer. Previously, we identify head and neck cancer initiating cells (HN-CICs), which are highly tumorigenic and resistant to conventional therapy. Therefore, development of drug candidates that effectively target HN-CICs would benefit future head and neck cancer therapy. In this study, we first successfully screened for an active component, named YMGKI-1, from natural products ofAntrodia cinnamomeaMycelia (ACM), which can target the stemness properties of HNSCC. Treatment of YMGKI-1 significantly downregulated the aldehyde dehydrogenase (ALDH) activity, one of the characteristics of CIC in HNSCC cells. Additionally, the tumorigenic properties of HNSCC cells were attenuated by YMGKI-1 treatmentin vivo. Further, the stemness properties of HN-CICs, which are responsible for the malignancy of HNSCC, were also diminished by YMGKI-1 treatment. Strikingly, YMGKI-1 also effectively suppressed the cell viability of HN-CICs but not normal stem cells. Finally, YMGKI-1 induces the cell death of HN-CICs by dysregulating the exaggerated autophagic signaling pathways. Together, our results indicate that YMGKI-1 successfully lessens stemness properties and tumorigenicity of HN-CICs. These findings provide a new drug candidate from purified components of ACM as an alternative therapy for head and neck cancer in the future.

Lugol Iodine Staining Test in Early Detection of Head and Neck Cancer

2017 ◽  
Vol 68 (8) ◽  
pp. 1944-1945
Author(s):  
Catalin Stefan ◽  
Gabriel Lostun ◽  
Alexandra Lostun
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Iodine Staining ◽  
Examination Techniques ◽  
Staining Techniques ◽  
Malignant Lesions

Head and neck cancer represents 3% of malignancies, and it is associated with high mortality due to advanced stage diagnosis. In early stages, the symptomatology can either be absent or be very common, misleading the patient who often ignores it. Early diagnosis of head and neck neoplasia is essential for a favorable long-term outcome. Lately new in vivo examination techniques were developed, and older ones have been improved. Today, in vivo staining techniques are an important tool in the diagnostic of head and neck cancer. Lugol iodine staining method provides valuable information concerning the tumor, allowing the surgeon to differentiate premalignant and malignant lesions.

scholarly journals Range probing as a quality control tool for CBCT based synthetic CTs: in vivo application for head and neck cancer patients

2021 ◽  
Author(s):  
Carmen Seller Oria ◽  
Adrian Thummerer ◽  
Jeffrey Free ◽  
Johannes A. Langendijk ◽  
Stefan Both ◽  
...  
Keyword(s):  
Quality Control ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Quality Control Tool ◽  
Control Tool

scholarly journals Anti-cancer effect of Atractylodes macrocephala extract by double induction of apoptotic and autophagic cell death in head and neck cancer cells

2017 ◽  
Vol 12 (2) ◽  
pp. 25 ◽  
Author(s):  
Ni Kou ◽  
Hyejoung Cho ◽  
Hye-Eun Kim ◽  
Qiaochu Sun ◽  
Kyuhyeon Ahn ◽  
...  
Keyword(s):  
Cell Death ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Video Clip ◽  
Head And Neck Carcinoma ◽  
Autophagic Cell Death ◽  
Apoptosis Resistance ◽  
Apoptotic Pathway ◽  
Atractylodes Macrocephala

<p class="MS">The apoptosis resistance restricts the efficacy of traditional therapies of head and neck squamous cell carcinoma (HNSCC). To overcome this problem, <em>Atractylodes macrocephala</em>, a traditional Korean and Chinese herbal medicine, has been used in clinical practice. In the present study, the anticancer effect of <em>A. macrocephala</em> extract was investigated and its underlying mechanisms using head and neck cancer KB cell line. The extract-induced cytotoxicity was mediated by autophagic cell death as well as apoptosis in HNSCC cells though extrinsic apoptotic pathway and the Akt/mTOR autophagic pathway. This study suggests that <em>A. macrocephala</em> extracts can be a potential drug to overcome side effects and susceptibility for head and neck carcinoma by double induction of apoptosis and autophagy.</p><p class="MS"><strong>Video Clip of Methodology</strong>: 6 min 27 sec  <a href="https://www.youtube.com/v/iRpGT4zpfs4">Full Screen</a>    <a href="https://www.youtube.com/watch?v=iRpGT4zpfs4">If Failed</a></p>

scholarly journals Correction: In Vitro and In Vivo Synergistic Antitumor Activity of the Combination of BKM120 and Erlotinib in Head and Neck Cancer: Mechanism of Apoptosis and Resistance

2020 ◽  
Vol 19 (9) ◽  
pp. 1955-1955
Author(s):  
Abu Syed Md Anisuzzaman ◽  
Abedul Haque ◽  
Dongsheng Wang ◽  
Mohammad Aminur Rahman ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Antitumor Activity ◽  
Head And Neck ◽  
Neck Cancer ◽  
Synergistic Antitumor Activity

Impact of daily anatomical changes on EPID-based in vivo dosimetry of VMAT treatments of head-and-neck cancer

2015 ◽  
Vol 116 (1) ◽  
pp. 70-74 ◽  
Author(s):  
Roel A. Rozendaal ◽  
Ben J. Mijnheer ◽  
Olga Hamming-Vrieze ◽  
Anton Mans ◽  
Marcel van Herk
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
In Vivo Dosimetry ◽  
Anatomical Changes
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