Abstract 4772: A novel agonist antibody to human death receptor 4, AY4, induces apoptotic cell death in head and neck cancer through ROS generation:in vitroandin vivo

2011 ◽  
Author(s):  
Chul-Ho Kim ◽  
Bok-Soon Lee ◽  
Sung Un Kang ◽  
Hye Sook Hwang ◽  
Eun-Sil Sung ◽  
...  
Keyword(s):  
Cell Death ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Apoptotic Cell ◽  
Death Receptor ◽  
Apoptotic Cell Death ◽  
Agonist Antibody ◽  
Death Receptor 4 ◽  
Human Death

Single-cell microinjection of cytochromec can result in gap junction-mediated apoptotic cell death of bystander cells in head and neck cancer

Head & Neck ◽  
2005 ◽  
Vol 27 (9) ◽  
pp. 794-800 ◽  
Author(s):  
Douglas K. Frank ◽  
Bozena Szymkowiak ◽  
Olgica Josifovska-Chopra ◽  
Torahiko Nakashima ◽  
Kathleen W. Kinnally
Keyword(s):  
Cell Death ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Gap Junction ◽  
Single Cell ◽  
Neck Cancer ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Bystander Cells

scholarly journals A novel agonistic antibody to human death receptor 4 induces apoptotic cell death in various tumor cells without cytotoxicity in hepatocytes

2009 ◽  
Vol 8 (8) ◽  
pp. 2276-2285 ◽  
Author(s):  
Eun-Sil Sung ◽  
Kyung-Jin Park ◽  
Seung-Hyun Lee ◽  
Yoon-Seon Jang ◽  
Sang-Koo Park ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cells ◽  
Apoptotic Cell ◽  
Death Receptor ◽  
Apoptotic Cell Death ◽  
Agonistic Antibody ◽  
Death Receptor 4 ◽  
Human Death

Hybrid Benzoxazole-Coumarin Compounds Induce Death Receptor-Mediated Switchable Apoptotic and Necroptotic Cell Death on HN-5 Head and Neck Cancer Cell Line

2017 ◽  
Vol 17 (4) ◽  
pp. 608-614 ◽  
Author(s):  
Sahar Yaghmaei ◽  
Parichehr Ghalayani ◽  
Siamak Salami ◽  
Farahnaz Nourmohammadian ◽  
Soheila Koohestanimobarhan ◽  
...  
Keyword(s):  
Cell Death ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cell Line ◽  
Cancer Cell ◽  
Neck Cancer ◽  
Death Receptor ◽  
Cancer Cell Line ◽  
Coumarin Compounds

scholarly journals Prognostic Value of Homotypic Cell Internalization by Nonprofessional Phagocytic Cancer Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Manuela Schwegler ◽  
Anna M. Wirsing ◽  
Hannah M. Schenker ◽  
Laura Ott ◽  
Johannes M. Ries ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tissue Sample ◽  
Apoptotic Cell ◽  
Treatment Strategies ◽  
Tissue Microarrays ◽  
Cell Internalization ◽  
Cell Structures

Background. In this study, we investigated the prognostic role of homotypic tumor cell cannibalism in different cancer types.Methods. The phenomenon of one cell being internalized into another, which we refer to as “cell-in-cell event,” was assessed in 416 cases from five head and neck cancer cohorts, as well as one anal and one rectal cancer cohort. The samples were processed into tissue microarrays and immunohistochemically stained for E-cadherin and cleaved caspase-3 to visualize cell membranes and apoptotic cell death.Results. Cell-in-cell events were found in all of the cohorts. The frequency ranged from 0.7 to 17.3 cell-in-cell events per mm2. Hardly any apoptotic cells were found within the cell-in-cell structures, although apoptotic cell rates were about 1.6 to two times as high as cell-in-cell rates of the same tissue sample. High numbers of cell-in-cell events showed adverse effects on patients’ survival in the head and neck and in the rectal cancer cohorts. In multivariate analysis, high frequency was an adverse prognostic factor for overall survival in patients with head and neck cancer (p=0.008).Conclusion. Cell-in-cell events were found to predict patient outcomes in various types of cancer better than apoptosis and proliferation and might therefore be used to guide treatment strategies.

scholarly journals Anti-cancer effect of Atractylodes macrocephala extract by double induction of apoptotic and autophagic cell death in head and neck cancer cells

2017 ◽  
Vol 12 (2) ◽  
pp. 25 ◽  
Author(s):  
Ni Kou ◽  
Hyejoung Cho ◽  
Hye-Eun Kim ◽  
Qiaochu Sun ◽  
Kyuhyeon Ahn ◽  
...  
Keyword(s):  
Cell Death ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Video Clip ◽  
Head And Neck Carcinoma ◽  
Autophagic Cell Death ◽  
Apoptosis Resistance ◽  
Apoptotic Pathway ◽  
Atractylodes Macrocephala

<p class="MS">The apoptosis resistance restricts the efficacy of traditional therapies of head and neck squamous cell carcinoma (HNSCC). To overcome this problem, <em>Atractylodes macrocephala</em>, a traditional Korean and Chinese herbal medicine, has been used in clinical practice. In the present study, the anticancer effect of <em>A. macrocephala</em> extract was investigated and its underlying mechanisms using head and neck cancer KB cell line. The extract-induced cytotoxicity was mediated by autophagic cell death as well as apoptosis in HNSCC cells though extrinsic apoptotic pathway and the Akt/mTOR autophagic pathway. This study suggests that <em>A. macrocephala</em> extracts can be a potential drug to overcome side effects and susceptibility for head and neck carcinoma by double induction of apoptosis and autophagy.</p><p class="MS"><strong>Video Clip of Methodology</strong>: 6 min 27 sec  <a href="https://www.youtube.com/v/iRpGT4zpfs4">Full Screen</a>    <a href="https://www.youtube.com/watch?v=iRpGT4zpfs4">If Failed</a></p>

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