Based on the characteristic of oilfield development programs, we comprehensive analyzed the influence of development and economical factors on development program, and constructed a comparative evaluation factors system of oilfield development program. In addition, based on the comparative analysis of grey theory and fuzzy evaluation, a grey-fuzzy appraisal method was set up and successfully applied to the evaluation of oilfield development programs. Grey theory was used to describe the factors that are difficult to quantification, and the analytic hierarchy process was used to confirm the appraisal factor’s weight and grey level. Furthermore, we chose eight development programs of an oilfield as our evaluation target and get an option sequence by using the grey-fuzzy method. The result shows that, grey-fuzzy methods have more advantage than fuzzy method in the evaluation of oilfield development programs.