scholarly journals Lung Volume Reduction Surgery for Emphysema Treatment: State-of-the-Art and Perspectives

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Eugenio Pompeo

Lung volume reduction surgery (LVRS) has shown an improve for up to several years respiratory function, exercise capacity, and quality of life in selected patients with severe emphysema and low exercise capacity, particularly if upper-lobe predominance of disease is radiologically recognized. However, mortality and morbidity rates of LVRS have been not negligible leading to raising question as to the cost-effectiveness of the procedure and resulting in a progressive decline in its use although a considerable number of patients meet selection criteria and could potentially benefit of this treatment modality. In recent years, an active investigation aimed at developing less invasive strategies that might allow us to achieve long-term results as satisfactory as those of the standard LVRS method but with fewer adverse effects has been undertaken. So far, novel options including nonresectional surgical and endoscopic LVRS methods hold promise but results from large studies with long follow-up are awaited to help define the most effective interventional treatment options for patients with severe emphysema. In this literature review an analysis of the main issues related to LVRS including selection criteria, mechanisms of action, results of currently available surgical and endoscopic methods, and some potential future perspectives is provided.

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e021368 ◽  
Author(s):  
Sara Buttery ◽  
Samuel V Kemp ◽  
Pallav L Shah ◽  
David Waller ◽  
Simon Jordan ◽  
...  

IntroductionAlthough lung volume reduction surgery and bronchoscopic lung volume reduction with endobronchial valves have both been shown to improve lung function, exercise capacity and quality of life in appropriately selected patients with emphysema, there are no direct comparison data between the two procedures to inform clinical decision-making.Methods and analysisWe describe the protocol of the CELEB study, a randomised controlled trial which will compare outcomes at 1 year between the two procedures, using a composite disease severity measure, the iBODE score, which includes body mass index, airflow obstruction, dyspnoeaand exercise capacity (incremental shuttle walk test).Ethics and disseminationEthical approval to conduct the study has been obtained from the Fulham Research Ethics Committee, London (16/LO/0286). The outcome of this trial will provide information to guide treatment choices in this population and will be presented at national and international meetings and published in peer-reviewed journals. We will also disseminate the main results to all participants in a letter.Trial registration numberISRCTN19684749; Pre-results.


2000 ◽  
Vol 92 (2) ◽  
pp. 157-164 ◽  
Author(s):  
L.L. Powell ◽  
H.P. Ha ◽  
D.L. Serna ◽  
M. Brenner ◽  
M. Gaon ◽  
...  

2019 ◽  
Vol 107 (4) ◽  
pp. 1068-1073
Author(s):  
Chelsea R. Horwood ◽  
Daniel Mansour ◽  
Mahmoud Abdel-Rasoul ◽  
Gregory Metzger ◽  
Jing Han ◽  
...  

Lung ◽  
2000 ◽  
Vol 178 (6) ◽  
pp. 381-389 ◽  
Author(s):  
K. Nezu ◽  
M. Yoshikawa ◽  
T. Yoneda ◽  
K. Kushibe ◽  
T. Kawaguchi ◽  
...  

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