scholarly journals The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Kentaro Kawabe ◽  
Fumie Horiuchi ◽  
Yasunori Oka ◽  
Shu-ichi Ueno

Children with autism spectrum disorders (ASD), including autistic disorder, frequently suffer from comorbid sleep problems. An altered melatonin rhythm is considered to underlie the impairment in sleep onset and maintenance in ASD. We report three cases with autistic disorder in whom nocturnal symptoms improved with ramelteon, a selective melatonin receptor agonist. Insomnia and behavior, assessed using the Clinical Global Impression-Improvement Scale, improved in two cases with 2 mg ramelteon and in the third case with 8 mg ramelteon. Our findings demonstrate that ramelteon is effective not only for insomnia, but for behavioral problems as well, in patients with autistic disorder.

2020 ◽  
Vol 8 (2) ◽  
pp. 1-5
Author(s):  
Ashok Kumar ◽  
Shweta Joshi ◽  
Sushil Ojha

Background: Autism Spectrum Disorder (ASD) includes neurodevelopmental problems throughout life that affect all areas of child development such as abnormal and impaired social interaction, problems in communication, restricted interest, repetitive and stereotypical behaviors. Sleep problems are most commonly complained by parents of children suffering from ASD. About 20-30% of children less than 5 years with normal development give complaints of sleep problems mainly of bedtime resistance, sleep onset delay and night awakening. Less commonly reported sleep disturbance by parents is nightmares or night terrors repetitive and stereotypical behavior. Less frequently reported complain is of breathing sleep disorder. It has already been proved by many studies that ASD children have more complaints about sleep problems than in normal children. But the data of children with ASD having sleep problems in the Indian population is less, so with our study we want to know the prevalence of ASD children with sleep problems in children of the hilly area of Uttarakhand. Objective: The study aims to know the different problems related to sleep faced by children suffering from ASD ( Age range from 4 to 10 years ) with autistic spectrum disorders using the Children’s Sleep Habit Questionnaire (Preschool and school-age, abbreviated version). Subjects and Method s: All patients of ASD presenting to the Psychiatry and Pediatric Outpatient department of Government Medical College and Susheela Tiwari trust Hospital, Haldwani, Uttarakhand from in February 2019 to January 2020. It’s a cross-sectional study of children with different problems related to sleep faced by children suffering from ASD ( Age range from 4 to 10 years ) with autistic spectrum disorders using the Children’s Sleep Habit Questionnaire (CSHQ) (Preschool and school-age, abbreviated version). Results: Demographic and clinical characteristics: The sample consisted of 30 children of ASD with sleep problems ( Mean Age 8.06 years, SD 3.25, Male 21 and Female 9 Children) age range from 4 Years to 10 Years and is compare from 30 normal children (mean age 9.06 Years, SD 3.15, Male 21 and Female 9) for the control group. Both groups were analysed using CSHQ tools. There were no statistically significant differences in age and gender (P value more than 0.05). About 60% (n=18) of the children suffering from ASD had an intellectual disability and 40% (n=12) children with ASD had normal Intellectual. Comparison of Total CSHQ score, bedtime resistance and sleep anxiety showed a statistically significant difference in children suffering from ASD with sleep disorder when compared from normal children. Using CSHQ tools sleep onset delay, night waking, day time sleepiness, parasomnias and sleep –disorder breathing does not show any statistical difference between children with ASD and normal children used as Control. Conclusion: This study compared sleep problems between children with ASD and typically developing children (4-10 Years of age) and examined associated factors of sleep problems in ASD from a different point of view.


2010 ◽  
Author(s):  

Developed by leading experts in developmental and behavioral pediatrics, the all-new AAP Developmental and Behavioral Pediatrics gives one place to turn for expert recommendations to deliver, coordinate, and/or monitor quality developmental/behavioral care within the medical home. The one resource with all the essentials for pediatric primary care providers. Evaluation and care initiation: Interviewing and counseling, Surveillance and screening, Psychoeducational testing, Neurodevelopmental assessment and medical evaluation. Development and disorders: Motor and cognitive development, Speech and language development and disorders, Social and emotional development, Autism spectrum disorders, Learning disabilities. Management solutions: Psychological interventions, Behavioral interventions, Psychopharmacologic management, Complementary and alternative medicine approaches. Contents: Introduction - Child Development: The Basic Science of Pediatrics, Nature, Nurture and Their Interactions in Child Development and Behavior, Interviewing and Counseling Children and Families, Basics of Child Behavior and Primary Care Management of Common Behavioral Problems, Early Intervention, Developmental and Behavioral Surveillance and Screening Within the Medical Home, Neurodevelopmental Assessment and Medical Evaluation, Developmental and Behavioral Diagnoses: The Spectrum and Continuum of Developmental Disabilities and Behavioral Disorders, Motor Development, Cognitive Development, Speech and Language Development and Disorders, Social and Emotional Development, Autism Spectrum Disorders, Psychoeducational Testing, Learning Disabilities, Attention-Deficit/Hyperactivity Disorder, Disruptive Behavior Disorders, Anxiety and Mood Disorders, Evidence-based Psychological and Behavioral Interventions, Principles of Psychopharmacologic Management, Complementary and Alternative Medicine in Developmental and Behavioral Pediatrics, Sensory Impairments: Hearing and Vision, Social and Community Services, Transition to Adult Medical Care, Billing and Coding for Developmental and Behavioral Problems in Outpatient Primary Care.


2018 ◽  
Vol 83 ◽  
pp. 270-279 ◽  
Author(s):  
Amy M. Shui ◽  
Terry Katz ◽  
Beth A. Malow ◽  
Micah O. Mazurek

2021 ◽  
Vol 27 (3) ◽  
pp. 3939-3946
Author(s):  
Sevginar Ibryamova ◽  
◽  
Veselin Petkov ◽  
Tsveteslava Ignatova-Ivanova ◽  
Georgi Kolev ◽  
...  

Autism is a complex disorder without a specific diagnosis, so the disease is defined by its specific characteristics described in the literature as cognitive defects, social, communication and behavioral problems, repetitive behaviors, unusual sensitivity to stimuli such as noise, restricted interests, and self stimulation. There are many models in the literature explaining the biology of autism, which are based on genetics, immunity, various environmental factors and diet. There is a lot of literature data that people with Autism Spectrum Disorders (ASD) often have gastrointestinal problems that also affect their behavior. ASD suffer developmental disabilities from an early age, which can be both physical and psychological. Often people suffer these problems even throughout their lives. This review aims to provide basic information on definitions, historical data, diagnostic methods, behavioral etiology, gastrointestinal and social problems in adults and children with ASD.


PEDIATRICS ◽  
2012 ◽  
Vol 130 (Supplement 2) ◽  
pp. S83-S90 ◽  
Author(s):  
Darryn M. Sikora ◽  
Kyle Johnson ◽  
Traci Clemons ◽  
Terry Katz

Autism ◽  
2019 ◽  
Vol 23 (7) ◽  
pp. 1630-1644 ◽  
Author(s):  
Joanne Tarver ◽  
Melanie Palmer ◽  
Sophie Webb ◽  
Stephen Scott ◽  
Vicky Slonims ◽  
...  

There is growing interest in the development of behavioral parent interventions targeting emotional and behavioral problems in children with autism spectrum disorders. Such interventions have potential to improve a number of child and parental well-being outcomes beyond disruptive child behavior. This systematic review and meta-analysis assesses evidence for the efficacy of behavioral parent interventions for disruptive and hyperactive child behavior in autism spectrum disorders, as well as parenting efficacy and stress. A total of 11 articles from nine randomized controlled trials were included. Sufficient data were available to calculate standardized mean difference and show favorable effects of behavioral parent interventions on parent-reported measures of child disruptive behavior (standardized mean difference = 0.67), hyperactivity (standardized mean difference = 0.31) and parent stress (standardized mean difference = 0.37); effects on parent efficacy are less clear (standardized mean difference = 0.39, p = 0.17). There were insufficient data to explore intervention effects on internalizing behavior in autism spectrum disorders, parenting behaviors, or observational and teacher-reported outcomes, providing important avenues for future research. This review adds to growing evidence of the efficacy of behavioral parent interventions for child behavior and parental well-being in autism spectrum disorders (Prospero: CRD42016033979).


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