Trabecular-Iris Circumference Volume in Open Angle Eyes Using Swept-Source Fourier Domain Anterior Segment Optical Coherence Tomography

Purpose. To introduce a new anterior segment optical coherence tomography parameter, trabecular-iris circumference volume (TICV), which measures the integrated volume of the peripheral angle, and establish a reference range in normal, open angle eyes.Methods. One eye of each participant with open angles and a normal anterior segment was imaged using 3D mode by the CASIA SS-1000 (Tomey, Nagoya, Japan). Trabecular-iris space area (TISA) and TICV at 500 and 750 µm were calculated. Analysis of covariance was performed to examine the effect of age and its interaction with spherical equivalent.Results. The study included 100 participants with a mean age of 50 (±15) years (range 20–79). TICV showed a normal distribution with a mean (±SD) value of 4.75 µL (±2.30) for TICV500 and a mean (±SD) value of 8.90 µL (±3.88) for TICV750. Overall, TICV showed an age-related reduction(P=0.035). In addition, angle volume increased with increased myopia for all age groups, except for those older than 65 years.Conclusions. This study introduces a new parameter to measure peripheral angle volume, TICV, with age-adjusted normal ranges for open angle eyes. Further investigation is warranted to determine the clinical utility of this new parameter.

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Assessment of anterior chamber configuration changes after phacoemulsification with swept-source optical coherence tomography

10.21203/rs.2.9863/v1 ◽

2019 ◽

Author(s):

Man Hu ◽

Qian Zheng ◽

Zhangliang Li ◽

Pingjun Chang ◽

Yun-e Zhao

Keyword(s):

Optical Coherence Tomography ◽

Cataract Surgery ◽

Anterior Chamber ◽

Anterior Segment ◽

Anterior Chamber Depth ◽

Optical Coherence ◽

Swept Source ◽

Narrow Angle ◽

Age Related ◽

Shallow Anterior Chamber

Abstract Background To assess the changes of anterior chamber angle in patients with shallow anterior chamber and normal anterior chamber after phacoemulsification and intraocular lens implantation (IOL) using anterior segment swept-source optical coherence tomography (AS-SS-OCT). Methods This was a prospective case control study; 60 eyes of 60 patients who underwent cataract surgery. Based on anterior chamber depth (ACD) and gonioscopy findings, the eyes were classified into two groups, shallow anterior chamber group (30 eyes) and normal anterior chamber group (30 eyes). AS-SS-OCT was used to measure ACD and angle parameters angle opening distance (AOD), angle recess area (ARA), trabecular iris space area(TISA), and trabecular iris angle (TIA). Serial changes in each group were measured before and 3 months after phacoemulsification and IOL, and the differences between the two groups were compared. Results All angle parameters including ACD, AOD, ARA, TISA, and TIA in both groups at 3 months after cataract surgery were significantly different from the preoperative values (p<0.01). In addition, we found significant differences of all angle parameters between groups of shallow anterior chamber (SAC) and normal anterior chamber (NAC) (All P< 0.05). Besides, the TISA750 in superior quadrant and anterior chamber volume (ACV) were significantly smaller in the group of SAC than those in the group of NAC (P = 0.041 and 0.002, respectively). Conclusions The parameters of anterior chamber increased significantly in both two groups but not increase to the same extent 3 months after phacoemulsification. Iris thickening may also be one of the narrow angle factors,not just age-related lens thickening.

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Accidental Corneal Intrastromal Intraocular Lens Implantation with the Wound-Assisted Technique and Clinical Course with Anterior Segment Optical Coherence Tomography

Case Reports in Ophthalmology ◽

10.1159/000514068 ◽

2021 ◽

pp. 283-287

Author(s):

Jo Moriya ◽

Shinichi Sakamoto ◽

Satoru Inoda ◽

Hidenori Takahashi ◽

Hidetoshi Kawashima

Keyword(s):

Optical Coherence Tomography ◽

Intraocular Lens ◽

Anterior Segment ◽

Corneal Stroma ◽

Age Related Macular Degeneration ◽

Optical Coherence ◽

Corrected Visual Acuity ◽

Age Related ◽

Intracameral Injection ◽

Air Tamponade

Accidental intraocular lens (IOL) implantation into the corneal stroma is a rare clinical entity that can occur during the wound-assisted technique. In this report, we describe a case of an 81-year-old man who underwent cataract surgery in which the IOL was implanted into the corneal stroma with the wound-assisted technique, and we present changes in anterior segment optical coherence tomography. The IOL was removed and reinserted after widening the incision. Air tamponade was created by intracameral injection. An anterior chamber tap was performed 10 h later to reduce increased intraocular pressure. Interlayer separation of the corneal stroma was confirmed 30 min postoperatively but was corrected 4 days later. The patient’s best-corrected visual acuity (BCVA) was logMAR 0.30, and he had been diagnosed with age-related macular degeneration before surgery. Although the opacity of the corneal stroma persisted, BCVA improved to logMAR 0. When using the wound-assisted technique for IOL insertion, surgeons should take care not to implant the IOL into the corneal stroma.

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The Spectrum of Central Choriocapillaris Abnormalities on Swept-Source Optical Coherence Tomography Angiography in the Fellow Eye of Unilateral Exudative Age-Related Macular Degeneration Patients: From Flow Deficits to Subclinical Non-Exudative Neovascularization

Journal of Clinical Medicine ◽

10.3390/jcm10122658 ◽

2021 ◽

Vol 10 (12) ◽

pp. 2658

Author(s):

Alexis Khorrami Kashi ◽

Eric Souied ◽

Selim Fares ◽

Enrico Borrelli ◽

Vittorio Capuano ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Degeneration ◽

Optical Coherence Tomography Angiography ◽

Clinical Findings ◽

Age Related Macular Degeneration ◽

Optical Coherence ◽

Swept Source ◽

Exudative Amd ◽

Age Related ◽

Fellow Eyes

We evaluated the spectrum of choriocapillaris (CC) abnormalities in the fellow eyes of unilateral exudative age-related macular degeneration (AMD) patients using swept-source optical coherence tomography angiography (SS-OCTA). Fellow eyes of unilateral exudative AMD patients were prospectively included between May 2018 and October 2018. Patients underwent a multimodal imaging including a SS-OCTA. Demographics and clinical findings were analyzed. The estimated prevalence of macular neovascularization (MNV) was computed. Number and size of flow deficits (FDs) and percentage of flow deficits (FD%) were computed on the compensated CC flow images with the Fiji software. We included 97 eyes of 97 patients (mean age was 80 ± 7.66 years, 39 males, 58 females). The prevalence of MNV in the studied eyes was 8.25% (8/97 eyes). In the 89 non-neovascular eyes, FD% averaged 45.84% ± 11.63%, with a corresponding total area of FDs of 4.19 ± 1.12 mm2. There was a higher prevalence of drusenoid pigment epithelial detachment in eyes with subclinical neovascularization (p = 0.021). Fellow eyes with unilateral exudative AMD encompassed a series of CC abnormalities, from FDs of the aging CC to subclinical non-exudative MNV.

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Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.19-27861 ◽

2019 ◽

Vol 60 (15) ◽

pp. 4985 ◽

Cited By ~ 4

Author(s):

Phillip X. Braun ◽

Nihaal Mehta ◽

Isaac Gendelman ◽

A. Yasin Alibhai ◽

Eric M. Moult ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Degeneration ◽

Optical Coherence Tomography Angiography ◽

Global Analysis ◽

Age Related Macular Degeneration ◽

Optical Coherence ◽

Swept Source ◽

Age Related

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Objective quantification of lens nuclear opacities using swept-source anterior segment optical coherence tomography

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2020-318334 ◽

2021 ◽

pp. bjophthalmol-2020-318334

Author(s):

Wei Wang ◽

Jiaqing Zhang ◽

Xiaoxun Gu ◽

Xiaoting Ruan ◽

Xiaoyun Chen ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Anterior Segment ◽

Training Dataset ◽

Dissipated Energy ◽

Nuclear Density ◽

Optical Coherence ◽

Nuclear Cataract ◽

Swept Source ◽

Ultrasonic Time

Background/aimsThe primary objective is to quantify the lens nuclear opacity using swept-source anterior segment optical coherence tomography (SS-ASOCT) and to evaluate its correlations with Lens Opacities Classification System III (LOCS-III) system and surgical parameters. The secondary objective is to assess the diagnostic performance for hard nuclear cataract.MethodsThis cross-sectional study included 1222 patients eligible for cataract surgery (1222 eyes). The latest SS-ASOCT (CASIA-2) was used to obtain high-resolution lens images, and the average nuclear density (AND) and maximum nuclear density (MND) were measured by a custom ImageJ software. Spearman’s correlations analysis was used to assess associations of AND/MND with LOCS-III nuclear scores, visual acuity and surgical parameters. The subjects were then split randomly (9:1) into the training dataset and validating dataset. Receiver operating characteristic curves and calibration curves were constructed for the classification on hard nuclear cataract.ResultsThe AND and MND from SS-ASOCT images were significantly correlated with nuclear colour scores (AND: r=0.716; MND: r=0.660; p<0.001) and nuclear opalescence scores (AND: r=0.712; MND: r=0.655; p<0.001). The AND by SS-ASOCT images had the highest values of Spearman’s r for preoperative corrected distance visual acuity (r=0.3131), total ultrasonic time (r=0.3481) and cumulative dissipated energy (r=0.4265). The nuclear density had good performance in classifying hard nuclear cataract, with area under the curves of 0.859 (0.831–0.886) for AND and 0.796 (0.768–0.823) for MND.ConclusionObjective and quantitative evaluation of the lens nuclear density using SS-ASOCT images enable accurate diagnosis of hard nuclear cataract.

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Relevance of Swept-Source Anterior Segment Optical Coherence Tomography for Corneal Imaging in Patients With Flap-Related Complications After LASIK

Cornea ◽

10.1097/ico.0000000000001773 ◽

2019 ◽

Vol 38 (1) ◽

pp. 93-97 ◽

Cited By ~ 5

Author(s):

Khaled Abdelazeem ◽

Mohamed Sharaf ◽

Mohamed G. A. Saleh ◽

Ahmed M. Fathalla ◽

Wael Soliman

Keyword(s):

Optical Coherence Tomography ◽

Anterior Segment ◽

Optical Coherence ◽

Swept Source ◽

Corneal Imaging

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Morphometric measurement of Schlemm’s canal in normal human eye using anterior segment swept source optical coherence tomography

Journal of Biomedical Optics ◽

10.1117/1.jbo.17.1.016016 ◽

2012 ◽

Vol 17 (1) ◽

pp. 016016 ◽

Cited By ~ 14

Author(s):

Guohua Shi

Keyword(s):

Optical Coherence Tomography ◽

Anterior Segment ◽

Optical Coherence ◽

Morphometric Measurement ◽

Schlemm’S Canal ◽

Swept Source ◽

Human Eye ◽

Schlemm's Canal ◽

Normal Human

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The anterior and posterior biometric characteristics in primary angle-closure disease: Data based on anterior segment optical coherence tomography and swept-source optical coherence tomography

Indian Journal of Ophthalmology ◽

10.4103/ijo.ijo_936_20 ◽

2021 ◽

Vol 69 (4) ◽

pp. 865

Author(s):

Xiulan Zhang ◽

Wenbin Huang ◽

Xingyi Li ◽

Xinbo Gao

Keyword(s):

Optical Coherence Tomography ◽

Anterior Segment ◽

Angle Closure ◽

Optical Coherence ◽

Swept Source ◽

Primary Angle Closure

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Age-Related Changes in the Rhesus Macaque Eye

10.1101/2021.07.14.452427 ◽

2021 ◽

Author(s):

Kira Lin ◽

Tu Tran ◽

Soohyun Kim ◽

Sangwan Park ◽

Jiajia Chen ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Intraocular Pressure ◽

Rhesus Macaque ◽

Axial Length ◽

Rhesus Macaques ◽

Anterior Segment ◽

Optical Coherence ◽

Lens Thickness ◽

Age Related ◽

Age Related Changes

Purpose: To assess age-related changes in the rhesus macaque eye and evaluate them to corresponding human age-related eye disease. Methods: Data from eye exams and imaging tests including intraocular pressure (IOP), lens thickness, axial length, and retinal optical coherence tomography (OCT) images were evaluated from 142 individuals and statistically analyzed for age-related changes. Quantitative autofluorescence (qAF) was measured as was the presence of macular lesions as related to age. Results: Ages of the 142 rhesus macaques ranged from 0.7 to 29 years (mean=16.4 years, stdev=7.5 years). Anterior segment measurements such as IOP, lens thickness, and axial length were acquired. Advanced retinal imaging in the form of optical coherence tomography and qAF were obtained. Quantitative assessments were made and variations by age groups were analyzed to compare with established age-related changes in human eyes. Quantitative analysis of data revealed age-related increase in intraocular pressure, ocular biometry (lens thickness and axial length), and presence of macular lesions. Age-related changes in thicknesses of retinal layers on OCT were observed and quantified. Age was correlated with increased qAF. Conclusions: The rhesus macaque has age-related ocular changes similar to humans. IOP increases with age while retinal ganglion cell layer thickness decreases. Macular lesions develop in some aged animals. Our findings support the concept that rhesus macaques may be useful for the study of important age-related diseases such as glaucoma, macular diseases, and cone disorders, and for development of therapies for these diseases.

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