scholarly journals Investigation of Serum Oxidized Low-Density Lipoprotein IgG Levels in Patients with Angiographically Defined Coronary Artery Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mohsen Moohebati ◽  
Vahid Kabirirad ◽  
Majid Ghayour-Mobarhan ◽  
Habibollah Esmaily ◽  
Shima Tavallaie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Significant Difference ◽  
Artery Disease

It has been suggested that antioxidized low-density lipoprotein (anti-oxLDL) antibodies play a role in the pathogenesis of atherosclerosis. The aim of this study was to measure serum ox-LDL IgG levels in 31 patients with angiographically defined coronary artery disease (CAD) (≥50% stenosis in at least one major coronary artery; CAD+group) and compare these levels with those of 32 subjects with <50% coronary stenosis (CAD−group) and 24 healthy age- and sex-matched controls using ELISA. We did not find any significant difference between CAD+, CAD−, and control groups in regard to oxLDL IgG levels (P=0.83). Serum oxLDL IgG levels did not differ between 1VD (one vessel disease), 2VD (2 vessels disease), and 3VD (3 vessels disease) subgroups of CAD+patients (P=0.20). Serum anti-oxLDL titers were only significantly correlated with LDL-C in the CAD+group (P<0.05) and waist and hip circumference (P<0.05andP<0.01, resp.) in the CAD−group. In stepwise regression analysis, none of the conventional cardiovascular risk factors was associated with serum ox-LDL IgG levels. The present results suggest that serum levels of ox-LDL IgG are neither associated with the presence and severity of CAD nor with the conventional cardiovascular risk factors.

scholarly journals Epidemiological Analysis of Major Cardiovascular Risk Factors in 1,508 Indian Adults Stratified by Age and Gender

2021 ◽  
Vol 8 (11) ◽  
pp. 608-612
Author(s):  
Sunil S. Thanvi ◽  
Sunil K. Karna ◽  
Utsav B Patel
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Vitamin D3 ◽  
Density Lipoprotein ◽  
Age And Gender ◽  
Artery Disease ◽  
And Gender

BACKGROUND Routine screening of healthy individuals for the presence of cardiovascular risk factors is important for identification of high-risk coronary artery disease (CAD) patients at early stage and to provide preventive care. Considering the high burden of CAD, such investigations are of significant importance in Indian context. METHODS In this cross-sectional study, adult individuals (18 – 68 years) were evaluated for pre-existing diseases, lipid profile, blood glucose profile, thyroid profile, haemoglobin (Hb) and vitamins D3 and B12 levels after obtaining informed consent. These variables were compared between patients stratified based on their gender and age (< 40, 40 – 60, > 60 years). RESULTS A total of 1,508 participants (mean age: 49 ± 11 years; 49.9 % females) were investigated. Hypertension, diabetes, dyslipidaemia, anaemia, vitamin D3 and B12 deficiencies, hyperthyroidism, and hypothyroidism were observed in 31.2 %, 26.5 %, 32.0 %, 8.6 %, 35.3 %, 25.1 %, 21.0 % and 0.6 % of patients respectively. Prevalence of hypertension, diabetes, and dyslipidaemia increased with ageing, while deficiencies of Hb, vitamin D3, and vitamin B12 as well as hyperthyroidism and hypothyroidism were comparable across all age groups. Males were more prone to hypertension, diabetes, and dyslipidaemia, while females were more prone to have Hb deficiency, hyperthyroidism, and hypothyroidism. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), fasting blood sugar (FBS), vitamin D3, and vitamin B12 were elevated with increase in age, while Hb levels decreased. Males exhibited higher levels of TG, low-density lipoprotein cholesterol (LDL-C), TC / HDL, LDL / HDL, FBS, and Hb, while females displayed higher levels of vitamin D3 and B12. CONCLUSIONS Our findings verify the role of age and gender on majority of cardiovascular risk factors. The high prevalence of cardiovascular risk factors is alarming and demands the need for appropriate health-care measures. KEYWORDS Age, Coronary Artery Disease, Gender, Risk Factor

Abstract 112: Low Plasma Low-density Lipoprotein Cholesterol Level as a Risk Factor for Cancer in Patients With Newly Diagnosed Coronary Artery Disease

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Xiaofeng Chen ◽  
Jianjun Jiang ◽  
Haihua Yang ◽  
Bing Wang ◽  
Yinsheng Xue ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Stent Implantation ◽  
Low Density Lipoprotein ◽  
Cell Cancer ◽  
Density Lipoprotein ◽  
Low Density ◽  
Newly Diagnosed ◽  
Artery Disease

Background and Objective: Coronary artery disease (CAD) and cancer are the leading causes of death worldwide and share some risk factors, such as aging and smoking. Concurrence of CAD and cancers makes diagnosis and treatment more clinical challenging. In patients who need stent implantation followed by dual antiplatelet therapy, fatal perioperative complications such as bleeding and stent thrombosis may occur. There is no data regarding the prevalence and risk factors of cancer in patients with CAD. This study investigated the cancer prevalence and risk factors in patients with newly diagnosed CAD. Methods and Results: Three thousand and one hundred and eighty six consecutive patients with newly angiographically documented CAD were prospectively enrolled between January 2009 and March 2015. Serum levels of tumor markers, including carcinoembryonic antigen, alpha fetoprotein, carbohydrate antigen125, carbohydrate antigen 153, carbohydrate antigen199, squamous cell cancer antigen, and prostate-specific antigen, were measured. Diagnosis of cancer was confirmed by pathology or imaging with ultrasound, computed tomography or magnetic resonance. The prevalence of cancer in CAD patients was 1.1% (35 out of 3186), involving the in gastroenterogical, respiratory, endocrine and exocrine, urinary and hematopoietic systems. Among these cancer patients, 17 patients had stent implantation, with 7 AMI patients undergoing emergency PCI. Multivariate analysis revealed that, in addition to male gender and advanced age, lower plasma low-density lipoprotein (LDL) cholesterol levels were independently associated with the occurrence of cancer in CAD patients (P<0.01). Conclusion: Cancers occur in 1.1% of patients with CAD. Low LDL levels may increase the risk for cancers in the CAD patients. Further large scale studies are needed to validate this association.

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