scholarly journals A Case of Primary Subglottic Malignant Melanoma with a Successful Surgical Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Shahzad Ahmad ◽  
Mahmoud Abdelghany ◽  
Curtis Goldblatt ◽  
Owen Stark ◽  
Nicholas Masciotra
Keyword(s):  
Surgical Treatment ◽  
Malignant Melanoma ◽  
Excisional Biopsy ◽  
Human Melanoma ◽  
Primary Malignant Melanoma ◽  
Shortness Of Breath ◽  
S 100 ◽  
Hmb 45

Primary subglottic malignant melanoma is a very rare and underdiagnosed neoplasm. We are reporting a case of primary malignant melanoma of subglottic mucosa in a 78-year-old woman who presented to our hospital with shortness of breath and hoarseness of voice. Laryngoscopy and excisional biopsy along with immunoreactivity to S-100 and human melanoma black-45 (HMB-45) confirmed the diagnosis. The patient was treated with laryngectomy followed by radiotherapy. Five years following surgical treatment, she continues to be asymptomatic. To our knowledge, there is only one reported case of primary malignant melanoma of subglottic mucosa in the medical literatures.

scholarly journals Primary Melanoma of the Lung: A Systematic Review

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 576
Author(s):  
Panagiotis Paliogiannis ◽  
Antonella M. Fara ◽  
Gianfranco Pintus ◽  
Wael M. Abdel-Rahman ◽  
Maria Colombino ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Single Case ◽  
Left Lung ◽  
Case Series ◽  
Primary Melanoma ◽  
Primary Malignant Melanoma ◽  
S 100 ◽  
Main Determinants ◽  
Mitotic Figures ◽  
Rare Malignancy

Background and Objectives: The respiratory apparatus, generally affected by highly aggressive tumors like lung cancer and mesothelioma, is rarely affected by primary malignant melanoma. The aim of this review was to identify cases of primary malignant melanoma of the lung (PMML) published in the modern scientific literature, and to describe their main clinical, pathological and therapeutic features. Materials and Methods: A systematic search of publications in the electronic database PubMed has been performed using keywords, and the references of the selected articles were checked to identify additional missing studies. Results: Globally 52 papers reporting on 76 cases were identified. Among them there were 47 reports of a single case, three papers reporting on two cases each, and two larger case series published in 1997 and 2005 including eight and 15 cases, respectively. Conclusions: PMML was generally diagnosed in middle-aged males, without any apparent correlation with cigarette smoking. It was more frequently found in the lower lobes and the left lung. The tumors were generally pigmented, composed by epithelial and/or spindle cells with large nuclei and prominent nucleoli, nuclear atypia, and numerous mitotic figures; they commonly showed immunostaining for S-100, HMB 45 and Melan-A. Early detection and surgical resection were the main determinants of survival from this rare malignancy.

scholarly journals Primary retromolar malignant melanoma in a Latin American patient

2020 ◽  
Vol 48 (4) ◽  
pp. 030006052091924
Author(s):  
Carlos-Martín Ardila ◽  
Joan-Michael Arce-Jaramillo ◽  
Efraín Álvarez-Martínez
Keyword(s):  
Latin America ◽  
Malignant Melanoma ◽  
Latin American ◽  
Surgical Excision ◽  
Primary Malignant Melanoma ◽  
Ki 67 ◽  
Metastatic Lesions ◽  
Immunohistochemistry Staining ◽  
American Patient ◽  
Hmb 45

Primary malignant melanoma of the oral mucosa is rare and has scarcely been reported in patients from Latin America. The most frequently affected sites include the palate and gingiva of the maxilla. In this report, we describe primary malignant melanoma in a Latin American patient. A 3 × 3.5-cm black tumor was observed on the upper left retromolar area. The lesion exhibited a sessile base, irregular edges, soft consistency, and pain on palpation. Immunohistochemistry staining results were positive for S100 and HMB-45; the Ki-67 index was 20%. Contrast tomography of the skull, face, abdomen, and thorax, as well as ultrasound of the liver, did not reveal metastatic lesions. The patient underwent wide surgical excision of the lesion, followed by radiotherapy; he was subsequently rehabilitated with a somato prosthesis.

scholarly journals Melanomas malignos do rebordo alveolar na maxila: apresentação de um caso

2021 ◽  
pp. 191-196
Author(s):  
Luiz Kosminsky ◽  
Fernando Amaral ◽  
Ageu De Aquino Sales ◽  
Wellington Macedo
Keyword(s):  
Surgical Treatment ◽  
Malignant Melanoma ◽  
White Woman ◽  
Palliative Treatment ◽  
Primary Malignant Melanoma ◽  
Alveolar Ridge

A case of primary malignant melanoma on the upper alveolar ridge is reported in a thirsty six year old white woman. A partiar prohthetic denture acted probably as an irritative agent producing prechange of color of alveolor mucosa. Radiumtherapy was done as a palliative treatment. The death due to general metastasis occurred in les e than one yeer. The surgical treatment should be done preferently.

scholarly journals Malignant melanoma of the bladder: A case report

2014 ◽  
Vol 8 (1-2) ◽  
pp. 54 ◽  
Author(s):  
Hamide Sayar ◽  
Seyda Erdogan ◽  
Fulya Adamhasan ◽  
Esma Gurbuz ◽  
Mehmet Fatih İnci
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Immunohistochemical Staining ◽  
Correct Diagnosis ◽  
Primary Lesion ◽  
Histological Features ◽  
Malignant Melanomas ◽  
Metastatic Lesions ◽  
S 100 ◽  
Hmb 45

Primary malignant melanoma of the bladder is very rare. Rather than being a primary lesion, malignant melanomas of the bladder are more commonly metastatic lesions. The histopathological appearance largely does not differ from that of melanoma at other body sites. It is often difficult to discriminate whether a bladder melanoma is primary or metastatic. Therefore, a careful review of histological features and performing necessary immunohistochemical staining procedures for S-100 protein and HMB-45 are very important in achieving a correct diagnosis. We report a case of hypomelanotic malignant melanoma of the bladder. Despite the variety of therapies available for primary melanomas of the bladder, the prognosis is still poor.

scholarly journals Primary Spinal Cord Melanoma of Intradural Extramedullary Origin

2019 ◽  
Vol 10 (03) ◽  
pp. 522-525
Author(s):  
Ashish Sharma ◽  
Virendra Deo Sinha
Keyword(s):  
Spinal Cord ◽  
Malignant Melanoma ◽  
Histopathological Examination ◽  
Lower Limbs ◽  
Primary Malignant Melanoma ◽  
Magnetic Resonance Imaging Scan ◽  
Lumbosacral Region ◽  
Intensity Lesion ◽  
S 100 ◽  
L1 And L2

AbstractPrimary malignant melanoma is the very rare entity of the central nervous system. It accounts only 1% of all melanoma cases. A 67-year-old patient presented to us with lower back pain radiating to the left lower limb and progressive weakness of both lower limbs. She underwent magnetic resonance imaging scan of lumbosacral region that suggested T1 hyperintense, T2 hypointense, extramedullary altered signal intensity lesion at L1 and L2 vertebral level compressing terminal spinal cord, and cauda equine region. On histopathological examination, findings were suggestive of malignant melanoma that was confirmed with immunohistochemistry examination (positive for S-100, Melan-A, and HMB-45). Here, we are discussing an unusual case of primary malignant melanoma of conus and cauda equine region with comprehensive review regarding management and prognosis of the tumor.

Outcome of Surgical Treatment for Primary Malignant Melanoma of the Female Urethra

2004 ◽  
Vol 171 (2) ◽  
pp. 765-767 ◽  
Author(s):  
DAVID S. DiMARCO ◽  
CONNIE S. DiMARCO ◽  
HORST ZINCKE ◽  
MAURICE J. WEBB ◽  
GARY L. KEENEY ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Malignant Melanoma ◽  
Primary Malignant Melanoma ◽  
Female Urethra

scholarly journals Case report of vaginal melanoma

2016 ◽  
Author(s):  
Inderjit Kaur ◽  
Swarupa Mitra ◽  
Manoj Kumar Sharma ◽  
Upasna Saxena ◽  
Parveen Ahlawat ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Soft Tissue ◽  
Invasive Carcinoma ◽  
Positive Margin ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Full Thickness ◽  
Vaginal Cuff ◽  
S 100 ◽  
Hmb 45

Primary malignant melanoma of vagina is a rare disease with a predilection for local recurrence, distant metastasis and short survival time. Due to the low incidence and lack of reporting in the literature, treatment choices still remain controversial. We describe 2 cases of vaginal malignant melanoma. A 42 yr old female presented with complaints of post coital and per vaginal bleed of 1 month duration. Examination findings show growth 6 cm x 6 cm on anterior vaginal wall, another 3 x 3 cm lesion on right lateral vaginal wall. Vaginal biopsy showed malignant melanoma, S-100 and HMB-45 positive while negative for CK and LCA. MRI Whole abdomen showed altered lesion [3.8cm (AP), 6.0cm (TR) and 4.9cm (CC)] in upper 2/3rd of vagina extending into vaginal fornices and abutting right lower cervix superiorly, right paravaginal extension and mesorectal fascia. No significant enlarged lymph nodes were seen. In view of localised disease she underwent Type III Radical hysterectomy with bilateral salpingo-ophorectomy with bilateral pelvic lymphnode dissection with total vaginectomy. Histopathology s/o 2 tumour nodules, one located in the anterior vaginal cuff measuring – 5 x 5 x 3.2 cm, another located in right lateral vaginal cuff measuring 2.5 x 3 x 1.5 cm, malignant melanoma with involvement of the cervix with full thickness stromal invasion (2.8/2.8 cm,) invading perivaginal soft tissue, distance of invasive carcinoma from closest stromal margin <0.1cm (12 O’ clock), LVI, PNI – not seen, all pelvic LN free (0/25). In view of positive margin and full thickness stromal involvement, she received radiotherapy to pelvis and Inguinal region to a dose of 45 Gy/25# followed by a boost of 16 Gy/8# to the tumour bed till 01/01/16. Another case is a 40 yrs female, presented with complaints of bloody discharge per vaginum of 4 months duration. On examination, there was a large growth occupying the vagina till introitus. Cervix normal, para free. MRI Pelvis showed altered lesion involving left lateral uterine cervix and upper 2/3rd of vagina with full thickness stromal involvement with mild left parametrial, anterior and posterior paravaginal extension, measuring 2.9 x 4.5 x 5.3 cm. Few subcmlymphnodes were seen in bilateral external and internal iliac regions (L>R). Vaginal Biopsy was suggestive of Malignant Melanoma, expressing S-100, HMB 45 and SDX-10. Metastatic work up was negative. She underwent RH with total vaginectomy with bilateral PLND with RPLND. HPR showed exophytic black growth seen involving all quadrants of vagina, extending upwards into both lips of cervix – 7 x 6 x 2.5 cm, Malignant melanoma, distance of invasive carcinoma from closest margin: <0.1 cm (paravaginal soft tissue), 3/8 right Pelvic LN, ECE +, 01/9 Left pelvic LN, ECE absent, 0/6 Right common iliac LN, 0/1 Reperitoneal LN was seen. She received adjuvant radiotherapy to a dose of 50 Gy/25# to the pelvis and inguinals→ boost of 6 Gy/3# to nodal regions showing ECE & 10 Gy/5# to the primary region.

scholarly journals Case report of vaginal melanoma

2016 ◽  
Author(s):  
Inderjit Kaur
Keyword(s):  
Malignant Melanoma ◽  
Soft Tissue ◽  
Invasive Carcinoma ◽  
Positive Margin ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Full Thickness ◽  
Vaginal Cuff ◽  
S 100 ◽  
Hmb 45

Primary malignant melanoma of vagina is a rare disease with a predilection for local recurrence, distant metastasis and short survival time. Due to the low incidence and lack of reporting in the literature, treatment choices still remain controversial. We describe 2 cases of vaginal malignant melanoma. A 42 yr old female presented with complaints of post coital and per vaginal bleed of 1 month duration. Examination findings shows growth 6 cm x 6 cm on anterior vaginal wall, another 3 x 3 cm lesion on right lateral vagianl wall. Vaginal biopsy showed malignant melanoma, S-100 and HMB-45 positive while negative for CK and LCA. MRI Whole abdomen showed altered lesion [3.8 cm (AP), 6.0 cm (TR) and 4.9 cm (CC)] in upper 2/3rd of vagina extending into vaginal fornices and abutting right lower cervix superiorly, right paravaginal extension and mesorectal fascia. No significant enlarged lymph nodes were seen. In view of localised disease she underwent Type III Radical hysterectomy with bilateral salpingo-ophorectomy with bilateral pelvic lymphnode dissection with total vaginectomy. Histopathology s/o 2 tumour nodules, one located in the anterior vaginal cuff measuring – 5 x 5 x 3.2 cm, another located in right lateral vaginal cuff measuring 2.5 x 3 x 1.5 cm, malignant melanoma with involvement of the cervix with full thickness stromal invasion (2.8/2.8 cm,) invading perivaginal soft tissue, distance of invasive carcinoma from closest stromal margin <0.1 cm (12 O’ clock), LVI, PNI – not seen, all pelvic LN free (0/25). In view of positive margin and full thickness stromal involvement, she received radiotherapy to pelvis and Inguinal region to a dose of 45 Gy/25# followed by a boost of 16 Gy/8# to the tumour bed till 01/01/16. Another case is a 40 yrs female, presented with complaints of bloody discharge per vaginum of 4 months duration. On examination, there was a large growth occupying the vagina till introitus. Cervix normal, para free. MRI Pelvis showed altered lesion involving left lateral uterine cervix and upper 2/3rd of vagina with full thickness stromal involvement with mild left parametrial, anterior and posterior paravaginal extension, measuring 2.9 x 4.5 x 5.3 cm. Few subcmlymphnodes were seen in bilateral external and internal iliac regions (L>R). Vaginal Biopsy was suggestive of Malignant Melanoma, expressing S-100, HMB 45 and SDX-10. Metastatic work up was negative. She underwent RH with total vaginectomy with bilateral PLND with RPLND. HPR showed exophytic black growth seen involving all quadrants of vagina, extending upwards into both lips of cervix – 7 x 6 x 2.5 cm, Malignant melanoma, distance of invasive carcinoma from closest margin: <0.1 cm (paravaginal soft tissue), 3/8 right Pelvic LN, ECE +, 01/9 Left pelvic LN, ECE absent, 0/6 Right common iliac LN, 0/1 Reperitoneal LN was seen. She received adjuvant radiotherapy to a dose of 50 Gy/25# to the pelvis and inguinals→ boost of 6 Gy/3# to nodal regions showing ECE & 10Gy/5# to the primary region.

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