scholarly journals Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Vikram Sabapathy ◽  
George Tharion ◽  
Sanjay Kumar
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cell Therapy ◽  
Ethical Issues ◽  
Neural Cells ◽  
Experimental Conditions ◽  
Cord Injury ◽  
Therapy Strategies ◽  
Injury Models

The spinal cord injury leads to enervation of normal tissue homeostasis ultimately leading to paralysis. Until now there is no proper cure for the treatment of spinal cord injury. Recently, cell therapy in animal spinal cord injury models has shown some progress of recovery. At present, clinical trials are under progress to evaluate the efficacy of cell transplantation for the treatment of spinal cord injury. Different types of cells such as pluripotent stem cells derived neural cells, mesenchymal stromal cells, neural stem cells, glial cells are being tested in various spinal cord injury models. In this review we highlight both the advances and lacuna in the field of spinal cord injury by discussing epidemiology, pathophysiology, molecular mechanism, and various cell therapy strategies employed in preclinical and clinical injury models and finally we discuss the limitations and ethical issues involved in cell therapy approach for treating spinal cord injury.

Cell therapy of combat related spinal cord injury with use of adult neural crest-derived multipotent stem cells

Cytotherapy ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. S223 ◽  
Author(s):  
V Grytsyk ◽  
A Rodnichenko ◽  
O Gubar ◽  
O Rybachuk ◽  
A Zlatska ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cell Therapy ◽  
Neural Crest ◽  
Multipotent Stem Cells ◽  
Cord Injury

Concomitant use of mesenchymal stem cells and neural stem cells for treatment of spinal cord injury: A combo cell therapy approach

2018 ◽  
Vol 668 ◽  
pp. 138-146 ◽  
Author(s):  
Seyed Mojtaba Hosseini ◽  
Mahsa Sani ◽  
Kh. Husnanin Haider ◽  
Mohammadreza Dorvash ◽  
Seyyed Mohyeddin Ziaee ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Neural Stem Cells ◽  
Therapy Approach ◽  
Cord Injury

Stem Cell Therapy in Spinal Cord Injury: In Vivo and Postmortem Tracking of Bone Marrow Mononuclear or Mesenchymal Stem Cells

2012 ◽  
Vol 8 (3) ◽  
pp. 953-962 ◽  
Author(s):  
Mevci Ozdemir ◽  
Ayhan Attar ◽  
Isinsu Kuzu ◽  
Murat Ayten ◽  
Enver Ozgencil ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cord Injury

scholarly journals Cell Therapy Strategies in the Repair of Spinal Cord Injury: Pros and Cons

2016 ◽  
Vol 4 (1) ◽  
pp. 55-66
Author(s):  
Sara Abdolahi ◽  
Hadi Aligholi ◽  
Sadegh Shirian ◽  
◽  
◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Therapy ◽  
Cord Injury ◽  
Pros And Cons ◽  
Therapy Strategies

Improved stem cell therapy of spinal cord injury using GDNF-overexpressed bone marrow stem cells in a rat model

Biologicals ◽  
2017 ◽  
Vol 50 ◽  
pp. 73-80 ◽  
Author(s):  
Mostafa Shahrezaie ◽  
Reyhaneh Nassiri Mansour ◽  
Bahare Nazari ◽  
Hadi Hassannia ◽  
Fatemeh Hosseini ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Rat Model ◽  
Bone Marrow Stem Cells ◽  
Cord Injury

scholarly journals CELL THERAPY OF STROKE AND SPINAL CORD INJURY COMPLICATIONS

2015 ◽  
Vol 6 (3) ◽  
pp. 48-58
Author(s):  
M A Konoplyannikov ◽  
V P Baklaushev ◽  
V A Kalsin ◽  
M A Tikhonovsky ◽  
A V Averyanov
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cell Therapy ◽  
Experimental Studies ◽  
Neurological Complications ◽  
Cord Injury ◽  
Different Types ◽  
Neural Stem Progenitor Cells ◽  
Further Development

The review analyzes the current advances of cell therapy for neurological complications of ischemic stroke and spinal cord injury (SCI). We demonstrate the most recent data on the use of different types of stem cells for the treatment of these severe damages, obtained both in experimental studies using animal models and in clinical studies. We particularly discuss the use of mesenchymal stem cells (MSC) and neural stem/progenitor cells (NSC/NPC) for the treatment of stroke and SCI. We also discuss the prospects for a further development of cell therapy of these diseases.

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