scholarly journals CELL THERAPY OF STROKE AND SPINAL CORD INJURY COMPLICATIONS

2015 ◽  
Vol 6 (3) ◽  
pp. 48-58
Author(s):  
M A Konoplyannikov ◽  
V P Baklaushev ◽  
V A Kalsin ◽  
M A Tikhonovsky ◽  
A V Averyanov
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cell Therapy ◽  
Experimental Studies ◽  
Neurological Complications ◽  
Cord Injury ◽  
Different Types ◽  
Neural Stem Progenitor Cells ◽  
Further Development

The review analyzes the current advances of cell therapy for neurological complications of ischemic stroke and spinal cord injury (SCI). We demonstrate the most recent data on the use of different types of stem cells for the treatment of these severe damages, obtained both in experimental studies using animal models and in clinical studies. We particularly discuss the use of mesenchymal stem cells (MSC) and neural stem/progenitor cells (NSC/NPC) for the treatment of stroke and SCI. We also discuss the prospects for a further development of cell therapy of these diseases.

Cell therapy of combat related spinal cord injury with use of adult neural crest-derived multipotent stem cells

Cytotherapy ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. S223 ◽  
Author(s):  
V Grytsyk ◽  
A Rodnichenko ◽  
O Gubar ◽  
O Rybachuk ◽  
A Zlatska ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cell Therapy ◽  
Neural Crest ◽  
Multipotent Stem Cells ◽  
Cord Injury

Concomitant use of mesenchymal stem cells and neural stem cells for treatment of spinal cord injury: A combo cell therapy approach

2018 ◽  
Vol 668 ◽  
pp. 138-146 ◽  
Author(s):  
Seyed Mojtaba Hosseini ◽  
Mahsa Sani ◽  
Kh. Husnanin Haider ◽  
Mohammadreza Dorvash ◽  
Seyyed Mohyeddin Ziaee ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Neural Stem Cells ◽  
Therapy Approach ◽  
Cord Injury

Stem Cell Therapy in Spinal Cord Injury: In Vivo and Postmortem Tracking of Bone Marrow Mononuclear or Mesenchymal Stem Cells

2012 ◽  
Vol 8 (3) ◽  
pp. 953-962 ◽  
Author(s):  
Mevci Ozdemir ◽  
Ayhan Attar ◽  
Isinsu Kuzu ◽  
Murat Ayten ◽  
Enver Ozgencil ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cord Injury

scholarly journals Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Junhao Deng ◽  
Yiling Zhang ◽  
Yong Xie ◽  
Licheng Zhang ◽  
Peifu Tang
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Embryonic Stem ◽  
Induced Pluripotent Stem Cell ◽  
Therapeutic Effects ◽  
Cord Injury ◽  
Neural Stem Progenitor Cells ◽  
Underlying Mechanisms ◽  
Induced Pluripotent

Spinal cord injury (SCI) is an intractable and worldwide difficult medical challenge with limited treatments. Neural stem/progenitor cell (NS/PC) transplantation derived from fetal tissues or embryonic stem cells (ESCs) has demonstrated therapeutic effects via replacement of lost neurons and severed axons and creation of permissive microenvironment to promote repair of spinal cord and axon regeneration but causes ethnical concerns and immunological rejections as well. Thus, the implementation of induced pluripotent stem cells (iPSCs), which can be generated from adult somatic cells and differentiated into NS/PCs, provides an effective alternation in the treatment of SCI. However, as researches further deepen, there is accumulating evidence that the use of iPSC-derived NS/PCs shows mounting concerns of safety, especially the tumorigenicity. This review discusses the tumorigenicity of iPSC-derived NS/PCs focusing on the two different routes of tumorigenicity (teratomas and true tumors) and underlying mechanisms behind them, as well as possible solutions to circumvent them.

scholarly journals Filling the Gap: Neural Stem Cells as A Promising Therapy for Spinal Cord Injury

2019 ◽  
Vol 12 (2) ◽  
pp. 65 ◽  
Author(s):  
Inês M. Pereira ◽  
Ana Marote ◽  
António J. Salgado ◽  
Nuno A. Silva
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Clinical Trials ◽  
Neural Stem Cells ◽  
Treatment Options ◽  
Experimental Studies ◽  
Current Treatment ◽  
Surgical Interventions ◽  
Cord Injury

Spinal cord injury (SCI) can lead to severe motor, sensory and social impairments having a huge impact on patients’ lives. The complex and time-dependent SCI pathophysiology has been hampering the development of novel and effective therapies. Current treatment options include surgical interventions, to stabilize and decompress the spinal cord, and rehabilitative care, without providing a cure for these patients. Novel therapies have been developed targeting different stages during trauma. Among them, cell-based therapies hold great potential for tissue regeneration after injury. Neural stem cells (NSCs), which are multipotent cells with inherent differentiation capabilities committed to the neuronal lineage, are especially relevant to promote and reestablish the damaged neuronal spinal tracts. Several studies demonstrate the regenerative effects of NSCs in SCI after transplantation by providing neurotrophic support and restoring synaptic connectivity. Therefore, human clinical trials have already been launched to assess safety in SCI patients. Here, we review NSC-based experimental studies in a SCI context and how are they currently being translated into human clinical trials.

scholarly journals Cell Therapy for Spinal Cord Injury by Neural Stem/Progenitor Cells Derived from iPS/ES Cells

2011 ◽  
Vol 8 (4) ◽  
pp. 668-676 ◽  
Author(s):  
Osahiko Tsuji ◽  
Kyoko Miura ◽  
Kanehiro Fujiyoshi ◽  
Suketaka Momoshima ◽  
Masaya Nakamura ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Therapy ◽  
Progenitor Cells ◽  
Es Cells ◽  
Cord Injury ◽  
Neural Stem Progenitor Cells

Biomaterial Strategies for Delivering Stem Cells as a Treatment for Spinal Cord Injury

2016 ◽  
Vol 202 (1-2) ◽  
pp. 42-51 ◽  
Author(s):  
Andrew Agbay ◽  
John M. Edgar ◽  
Meghan Robinson ◽  
Tara Styan ◽  
Krista Wilson ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Injured Spinal Cord ◽  
Electrospun Scaffolds ◽  
Biomaterial Scaffold ◽  
Cord Injury ◽  
Different Types ◽  
Biomaterial Scaffolds ◽  
Cell Phenotypes

Ongoing clinical trials are evaluating the use of stem cells as a way to treat traumatic spinal cord injury (SCI). However, the inhibitory environment present in the injured spinal cord makes it challenging to achieve the survival of these cells along with desired differentiation into the appropriate phenotypes necessary to regain function. Transplanting stem cells along with an instructive biomaterial scaffold can increase cell survival and improve differentiation efficiency. This study reviews the literature discussing different types of instructive biomaterial scaffolds developed for transplanting stem cells into the injured spinal cord. We have chosen to focus specifically on biomaterial scaffolds that direct the differentiation of neural stem cells and pluripotent stem cells since they offer the most promise for producing the cell phenotypes that could restore function after SCI. In terms of biomaterial scaffolds, this article reviews the literature associated with using hydrogels made from natural biomaterials and electrospun scaffolds for differentiating stem cells into neural phenotypes. It then presents new data showing how these different types of scaffolds can be combined for neural tissue engineering applications and provides directions for future studies.

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