T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives

Historically, primary Sjögren’s syndrome (pSS) was thought to be a T helper (h) 1 driven disease due to the predominance of CD4+T lymphocytes and their products in target organs and peripheral blood of patients. In the last decades, the identification of a number of T cell subsets, including Th17, T regulatory (Treg), and follicular helper T cells, challenged this long-standing paradigm and prompted to identify their role in pSS pathogenesis. In addition the impact of abnormal proinflammatory cytokine production, such as IL-6, IL-17, IL-22, and IL-23, has also attracted considerable attention. However, although several studies have been carried out in experimental models and patients with pSS, many aspects concerning the role of Treg cells and IL-17/Th17 cell system in pSS pathogenesis are not fully elucidated. In particular, the role played by different IL-17-producing T cell subsets as well as the effects of pharmacological therapies on Treg/Th17 cell balance represents an intriguing issue. The aim of this review article is to provide an overview of current knowledge on Treg cells and IL-17-producing T cells in pSS pathogenesis. We believe that these insights into pSS pathogenesis may provide the basis for successful therapeutic intervention in this disease.

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AB0535 Effect of metformin on the absolute number of cd4+ t cell subsets in patients with primary sjogren’s syndrome

10.1136/annrheumdis-2018-eular.2255 ◽

2018 ◽

Author(s):

X. Sun ◽

H. Yao ◽

J. He ◽

G. Chai ◽

L. Wei ◽

...

Keyword(s):

T Cell ◽

Sjogren’S Syndrome ◽

Absolute Number ◽

Sjogren's Syndrome ◽

Primary Sjögren’S Syndrome ◽

T Cell Subsets ◽

Cd4 T Cell ◽

Primary Sjogren’S Syndrome ◽

Primary Sjögren's Syndrome ◽

The Absolute

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Immunological alterations in newly diagnosed primary Sjögren's syndrome characterized by skewed peripheral T‐cell subsets and inflammatory cytokines

Scandinavian Journal of Rheumatology ◽

10.1080/03009740801910361 ◽

2008 ◽

Vol 37 (3) ◽

pp. 205-212 ◽

Cited By ~ 27

Author(s):

P. Szodoray ◽

I. Gal ◽

S. Barath ◽

M. Aleksza ◽

I. F. Horvath ◽

...

Keyword(s):

T Cell ◽

Inflammatory Cytokines ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Primary Sjögren’S Syndrome ◽

T Cell Subsets ◽

Newly Diagnosed ◽

Primary Sjogren’S Syndrome ◽

Primary Sjögren's Syndrome ◽

Immunological Alterations

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Disproportion of Helper T Cell Subsets in Peripheral Blood of Patients with Primary Sjogren's Syndrome

Autoimmunity ◽

10.3109/08916930008995989 ◽

2000 ◽

Vol 32 (1) ◽

pp. 67-72 ◽

Cited By ~ 14

Author(s):

Kenji Kohriyama ◽

Yoshio Katayama

Keyword(s):

T Cell ◽

Peripheral Blood ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Primary Sjögren’S Syndrome ◽

T Cell Subsets ◽

Primary Sjogren’S Syndrome ◽

Helper T Cell ◽

Primary Sjögren's Syndrome ◽

Sjögren‘S Syndrome

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Infiltrating T cells from patients with primary Sjögren's syndrome express restricted or unrestricted T cell receptor Vβ regions depending on the stage of the disease

European Journal of Immunology ◽

10.1002/eji.1830240128 ◽

1994 ◽

Vol 24 (1) ◽

pp. 181-185 ◽

Cited By ~ 28

Author(s):

Fabienne Legras ◽

Thierry Martin ◽

Anne-Marie Knapp ◽

Jean-Louis Pasquali

Keyword(s):

T Cells ◽

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Primary Sjögren’S Syndrome ◽

Primary Sjogren’S Syndrome ◽

Primary Sjögren's Syndrome ◽

T Cell Receptor Vβ

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MicroRNA-146a-5p enhances T helper 17 cell differentiation via decreasing a disintegrin and metalloprotease 17 level in primary sjögren’s syndrome

Bioengineered ◽

10.1080/21655979.2020.1870321 ◽

2021 ◽

Vol 12 (1) ◽

pp. 310-324

Author(s):

Xiaoyan Wang ◽

Shaojun Xin ◽

Youqing Wang ◽

Duo Ju ◽

Quan Wu ◽

...

Keyword(s):

Cell Differentiation ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Primary Sjögren’S Syndrome ◽

T Helper ◽

Primary Sjogren’S Syndrome ◽

T Helper 17 ◽

Primary Sjögren's Syndrome ◽

T Helper 17 Cell ◽

Sjögren‘S Syndrome

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Mucosal-associated invariant T cells are reduced and functionally immature in the peripheral blood of primary Sjögren's syndrome patients

European Journal of Immunology ◽

10.1002/eji.201646300 ◽

2016 ◽

Vol 46 (10) ◽

pp. 2444-2453 ◽

Cited By ~ 16

Author(s):

Jing J. Wang ◽

Cindy Macardle ◽

Helen Weedon ◽

Dimitra Beroukas ◽

Tatjana Banovic

Keyword(s):

T Cells ◽

Peripheral Blood ◽

Sjögren's Syndrome ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Primary Sjögren’S Syndrome ◽

Primary Sjogren’S Syndrome ◽

Primary Sjögren's Syndrome ◽

Invariant T Cells ◽

Sjögren‘S Syndrome

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Increased interleukin (IL)-7Rα expression in salivary glands of patients with primary Sjögren's syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2011-200744 ◽

2012 ◽

Vol 71 (6) ◽

pp. 1027-1033 ◽

Cited By ~ 28

Author(s):

A Bikker ◽

A A Kruize ◽

M Wenting ◽

M A Versnel ◽

J W J Bijlsma ◽

...

Keyword(s):

T Cells ◽

Salivary Glands ◽

Sjögren’S Syndrome ◽

Sjögren's Syndrome ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Primary Sjögren’S Syndrome ◽

Primary Sjogren’S Syndrome ◽

Primary Sjögren's Syndrome ◽

Sjögren‘S Syndrome

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Increased frequency of CCR7+CD4+ T cells from patients with primary Sjögren's syndrome: An indicator of disease activity rather than of damage severity

Cytokine ◽

10.1016/j.cyto.2018.04.015 ◽

2018 ◽

Vol 110 ◽

pp. 9-17 ◽

Cited By ~ 3

Author(s):

Chunling Wu ◽

Pingting Yang ◽

Haina Liu ◽

Weiguo Xiao ◽

Lijuan Zhao

Keyword(s):

T Cells ◽

Disease Activity ◽

Cd4 T Cells ◽

Sjögren's Syndrome ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Primary Sjögren’S Syndrome ◽

Primary Sjogren’S Syndrome ◽

Primary Sjögren's Syndrome ◽

Sjögren‘S Syndrome

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Ileocecal junction perforation by colonic T-cell lymphoma in a patient with primary Sjögren’s syndrome

Journal of International Medical Research ◽

10.1177/0300060519894434 ◽

2019 ◽

Vol 48 (4) ◽

pp. 030006051989443

Author(s):

Xiao-Chuan Liu ◽

Zhi-Wei Jia ◽

Yan Weng ◽

Lian-Jun Yang ◽

Jing Wang ◽

...

Keyword(s):

T Cell ◽

Sjögren's Syndrome ◽

Cell Lymphoma ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Primary Sjögren’S Syndrome ◽

T Cell Lymphoma ◽

Primary Sjogren’S Syndrome ◽

Primary Sjögren's Syndrome ◽

Sjögren‘S Syndrome

Primary Sjögren’s syndrome (pSS) is associated with an increased risk of lymphoma, especially non-Hodgkin’s lymphoma. The rarest pathological subtype is T-cell lymphoma. We herein report a case of a 52-year-old man with a 17-year history of pSS who was admitted to our hospital with chronic epigastric pain and a positive fecal occult blood test. Colonoscopy revealed multiple colonic ulcers, and histological and immunological studies demonstrated the T-cell origin of this lymphoma. However, the patient rejected all treatments. He developed recurrent intestinal obstruction and infection for 3 years until an intestinal perforation occurred. The right half of the colon was resected and colostomy was performed. However, the patient died of an intestinal fistula and intraperitoneal infection 40 days postoperatively. This case highlights the rarity of the correlation between T-cell lymphoma and pSS.

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