scholarly journals Preparation of Mesoporous Silica-Supported Chiral Amino Alcohols for the Enantioselective Addition of Diethylzinc to Aldehyde and Asymmetric Transfer Hydrogenation to Ketones

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Shaheen M. Sarkar ◽  
Md. Eaqub Ali ◽  
Md. Lutfor Rahman ◽  
Mashitah Mohd Yusoff
Keyword(s):  
Mesoporous Silica ◽  
Amino Alcohols ◽  
Optically Active ◽  
Transfer Hydrogenation ◽  
Catalytic Process ◽  
Asymmetric Transfer Hydrogenation ◽  
Chiral Catalyst ◽  
Aromatic Alcohols ◽  
Enantioselective Addition ◽  
Cubic Mesoporous

Optically active (−)-ephedrine, (−)-norephedrine, and (−)-prolinol were immobilized onto cubic mesoporous MCM-48 silica. The immobilized amino alcohols served as a heterogeneous chiral catalyst for the asymmetric addition of diethylzinc to aldehydes and transfer hydrogenation to ketones. The developed catalytic process yielded optically enriches secondary aromatic alcohols with 92–99% conversion and 70–82% enantioselectivity.

Facile assembly of bifunctional, magnetically retrievable mesoporous silica for enantioselective cascade reactions

2019 ◽  
Vol 55 (90) ◽  
pp. 13578-13581 ◽  
Author(s):  
Zhongrui Zhao ◽  
Fengwei Chang ◽  
Tao Wang ◽  
Lijian Wang ◽  
Lingbo Zhao ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Cross Coupling ◽  
Bifunctional Catalyst ◽  
Cascade Reactions ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Aromatic Alcohols ◽  
Hydrogenation Reactions ◽  
Successive Reduction

A magnetically recyclable bifunctional catalyst enables synergistic Suzuki cross-coupling/asymmetric transfer hydrogenation and successive reduction/asymmetric transfer hydrogenation reactions for the preparation of chiral aromatic alcohols.

ChemInform Abstract: Synthesis of Optically Active β-Amino Alcohols by Asymmetric Transfer Hydrogenation of α-Amino Ketones.

ChemInform ◽  
2010 ◽  
Vol 41 (28) ◽  
pp. no-no
Author(s):  
Zhou Xu ◽  
Songlei Zhu ◽  
Yongmin Liu ◽  
Ling He ◽  
Zhicong Geng ◽  
...  
Keyword(s):  
Amino Alcohols ◽  
Optically Active ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation

Synthesis of Optically Active β-Amino Alcohols by Asymmetric Transfer Hydrogenation of α-Amino Ketones

Synthesis ◽  
2009 ◽  
Vol 2010 (05) ◽  
pp. 811-817 ◽  
Author(s):  
Zhou Xu ◽  
Yawen Zhang ◽  
Songlei Zhu ◽  
Yongmin Liu ◽  
Ling He ◽  
...  
Keyword(s):  
Amino Alcohols ◽  
Optically Active ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation

Highly enantioselective asymmetric transfer hydrogenation (ATH) of α-phthalimide ketones

2015 ◽  
Vol 13 (27) ◽  
pp. 7513-7516 ◽  
Author(s):  
Zhou Xu ◽  
Yong Li ◽  
Jing Liu ◽  
Nan Wu ◽  
Ke Li ◽  
...  
Keyword(s):  
Good Yield ◽  
Amino Alcohols ◽  
Optically Active ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation

Optically active amino alcohols are obtained in good yield and excellent ee via an efficient asymmetric transfer hydrogenation (ATH) of α-phthalimide ketones.

Ru-Tethered (R,R)-TsDPEN with DMAB as an efficient catalytic system for high enantioselective one-pot synthesis of chiral β-aminol via asymmetric transfer hydrogenation

2021 ◽  
Vol 45 (12) ◽  
pp. 5357-5362
Author(s):  
Ashish A. Mishra ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Catalytic System ◽  
Optically Active ◽  
Transfer Hydrogenation ◽  
Selective Synthesis ◽  
Asymmetric Transfer Hydrogenation ◽  
One Pot ◽  
Chiral Catalyst ◽  
One Pot Synthesis ◽  
Dimethylamine Borane

This work reflects Ru-tethered-TsDPEN as an active chiral catalyst for one pot selective synthesis of optically active α-substituted alcohols and its derivatives from α-bromo ketones in the presence of dimethylamine borane (DMAB) as the hydrogen source.

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