scholarly journals Locally Advanced, Unresectable Squamous Cell Carcinoma of the Gallbladder

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Timothy J. Weatherall ◽  
Moon Fenton ◽  
Gitonga Munene ◽  
Paxton V. Dickson ◽  
Jeremiah L. Deneve
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Initial Presentation ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Gallbladder ◽  
Rare Malignancy ◽  
Worse Prognosis

Primary squamous cell carcinoma (SCC) of the gallbladder is a rare malignancy of the gallbladder, accounting for less than 5% of gallbladder pathology. Initial presentation is often similar to adenocarcinoma of the gallbladder. SCC tends to be more locally aggressive, however, and possesses a worse prognosis than adenocarcinoma. We report a case of locally advanced SCC of the gallbladder.

scholarly journals Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Krishna H. Suthar ◽  
Meghana Kesireddy ◽  
Mark Sides ◽  
Amit Correa ◽  
Aijan Ukudeyva ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Cancer ◽  
Locally Advanced ◽  
Neoadjuvant Chemoradiation ◽  
Pathologic Response ◽  
Stage Iiib ◽  
Rare Malignancy ◽  
Adjusted Incidence

Squamous cell carcinoma (SCC) of the urethra is a rare malignancy, comprising less than 1% of all malignancies. The annual age-adjusted incidence of urethral SCC is 4.3 per million in men and 1.5 per million in women. Due to the rarity of the disease, there are a limited number of prospective randomized controlled trials to evaluate the optimal management of locally advanced urethral SCC. Here, we present the case of a 47-year-old man with stage IIIB urethral squamous cell cancer that showed complete clinical and pathologic response to neoadjuvant chemoradiation with only 5-flurouracil after incomplete response to traditional chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP).

scholarly journals Squamous Cell Carcinoma of the Pancreas in a Patient with GermlineBRCA2Mutation-Response to Neoadjuvant Radiochemotherapy

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Anne M. Schultheis ◽  
Gia Phuong Nguyen ◽  
Monika Ortmann ◽  
Wolfgang Kruis ◽  
Reinhard Büttner ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Neoadjuvant Treatment ◽  
Pancreatic Tumors ◽  
Neoadjuvant Radiochemotherapy ◽  
Primary Squamous Cell Carcinoma ◽  
Cancer Syndrome ◽  
Carcinoma Of The Pancreas

Primary squamous cell carcinoma of the pancreas is a rare malignant neoplasia, accounting for approximately 0.5–2% of all malignant pancreatic tumors. These lesions are characterized by poor prognosis. Here we report on a case of a 57-year-old female patient with knownBRCA2germline mutation presenting with primary squamous cell carcinoma of the pancreas as the only malignancy. The tumor was locally advanced at the first presentation but responded almost completely to neoadjuvant radio-chemotherapy. Our case highlights the facts (i) that pancreatic carcinomas belong to the tumor spectrum of patients with theBRCA2-associated hereditary breast and ovarian cancer syndrome (HBOC) and (ii) that tumors of the pancreas can represent the first or even the only manifestation of HBOC. Furthermore, this case of a nonkeratinizing squamous cell carcinoma indicates that HBOC-associated carcinomas of the pancreas might be characterized by a broader morphological spectrum than was previously thought. SinceBRCAmutations cause deficiency of DNA double-strand breakage repair in tumors, neoadjuvant treatment regimens might become a reasonable option in HBOC-associated pancreatic carcinomas. To our knowledge, this is the first reported case of a primary pancreatic squamous cell carcinoma in a patient with this particular genetic background ofBRCA2-associated HBOC.

scholarly journals Primary Squamous Cell Carcinoma of the Urinary Bladder Presenting as Peritoneal Carcinomatosis

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Himisha Beltran ◽  
Brian D. Robinson ◽  
Scott T. Tagawa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Peritoneal Carcinomatosis ◽  
Squamous Cell ◽  
The United States ◽  
Primary Squamous Cell Carcinoma ◽  
Indwelling Catheter ◽  
Rare Malignancy ◽  
Tract Infections

We report an unusual case of a 78-year-old Caucasian female, who presented with peritoneal carcinomatosis and hypercalcemia, and was found to have a rapidly progressive primary squamous cell carcinoma of the urinary bladder. Squamous cell bladder carcinoma is a rare malignancy in the United States, accounting for just 1–3% of bladder tumors. Interestingly our patient lacked the established risk factors, including exposure to the parasiteSchistosoma haematobium, recurrent urinary tract infections, bladder calculi, radiation exposure, chronic indwelling catheter, neurogenic bladder, or tobacco abuse. Although hypercalcemia has been rarely described, an initial presentation of peritioneal carcinomatosis has not been previously reported.

scholarly journals Primary Squamous Cell Carcinoma of the Breast during Pregnancy: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
John Adi Ashindoitiang ◽  
Francis Adedayo Faduyile ◽  
Olufemi Joshua Taiwo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fatal Outcome ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Breast ◽  
Breast Cyst ◽  
Gestational Period ◽  
Pregnancy And Lactation ◽  
Rare Malignancy

Primary squamous cell carcinoma of the breast (SCCB) is a very rare malignancy of the breast and is generally aggressive. It is even rarer during the gestational period. Only few cases have been reported during pregnancy and lactation (Rokutanda et al., 2000). SCCB seen within the gestational period tends to be very aggressive and has a larger size than other breast carcinomas. Pure SCCB is derived from the epidermis of the breast, nipple, or metaplasia on chronic inflammatory background (Bige et al., 2007), such as complicated breast cyst, dermoid cyst, or abscess. We report a case of SCCB in a 30-year-old primigravida that had an aggressive propensity and fatal outcome.

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