scholarly journals Primary Squamous Cell Carcinoma of the Urinary Bladder Presenting as Peritoneal Carcinomatosis

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Himisha Beltran ◽  
Brian D. Robinson ◽  
Scott T. Tagawa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Peritoneal Carcinomatosis ◽  
Squamous Cell ◽  
The United States ◽  
Primary Squamous Cell Carcinoma ◽  
Indwelling Catheter ◽  
Rare Malignancy ◽  
Tract Infections

We report an unusual case of a 78-year-old Caucasian female, who presented with peritoneal carcinomatosis and hypercalcemia, and was found to have a rapidly progressive primary squamous cell carcinoma of the urinary bladder. Squamous cell bladder carcinoma is a rare malignancy in the United States, accounting for just 1–3% of bladder tumors. Interestingly our patient lacked the established risk factors, including exposure to the parasiteSchistosoma haematobium, recurrent urinary tract infections, bladder calculi, radiation exposure, chronic indwelling catheter, neurogenic bladder, or tobacco abuse. Although hypercalcemia has been rarely described, an initial presentation of peritioneal carcinomatosis has not been previously reported.

Basaloid Squamous Cell Carcinoma Occurring in the Urinary Bladder

2000 ◽  
Vol 124 (3) ◽  
pp. 455-459
Author(s):  
Funda Vakar-López ◽  
Jacki Abrams
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Metaplasia ◽  
The Body ◽  
Basaloid Squamous Cell Carcinoma ◽  
Upper Aerodigestive Tract ◽  
Tract Infections ◽  
Basaloid Squamous

Abstract Basaloid squamous cell carcinoma is a recently described, distinct variant of squamous cell carcinoma that arises predominantly in the upper aerodigestive tract. Herein we report a case of basaloid squamous cell carcinoma arising in the urinary bladder. The patient was a 60-year-old woman who experienced intractable urinary tract infections following multiple corrective surgical procedures for incontinence. Biopsies of cystoscopically evident flat lesions were performed, and the patient subsequently underwent a radical cystectomy. Histologically, the lesions consisted of nests of basaloid cells with brisk mitotic activity, areas of squamous differentiation along with areas of squamous metaplasia, and squamous cell carcinoma in situ. These features are similar to those of basaloid squamous cell carcinoma described elsewhere in the body. To our knowledge, this is the first reported case of basaloid squamous cell carcinoma in the urinary bladder.

scholarly journals High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder

2016 ◽  
Vol 29 (5) ◽  
pp. 511-515 ◽  
Author(s):  
Morgan Cowan ◽  
Simeon Springer ◽  
Doreen Nguyen ◽  
Diana Taheri ◽  
Gunes Guner ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Squamous Cell Carcinoma ◽  
Tert Promoter ◽  
High Prevalence ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

Metastatic squamous cell carcinoma of the paranasal sinuses from a primary squamous cell carcinoma of the urinary bladder

1989 ◽  
Vol 103 (6) ◽  
pp. 602-604 ◽  
Author(s):  
N. Kawai ◽  
K. Asakura ◽  
S. Sambe ◽  
A. Kataura ◽  
K. Enomoto
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urinary Tract ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Paranasal Sinuses ◽  
Renal Carcinoma ◽  
Urogenital Tract ◽  
Primary Squamous Cell Carcinoma ◽  
Metastatic Squamous Cell Carcinoma

AbstractMetastatic tumours of the paranasal sinuses from primary lesions of the urogenital tract are rare, with about 50 cases so far being reported in the literature. The most frequent primary lesions is a renal carcinoma. We have experienced a case of paransal sinus malignancy. There were no symptoms of urinary tract carcinoma preceding those in the paranasal sinuses. This case was later revealed at autopsy to be a metastasis from a diverticulum of the urinary bladder.

scholarly journals Primary Squamous Cell Carcinoma of the Breast during Pregnancy: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
John Adi Ashindoitiang ◽  
Francis Adedayo Faduyile ◽  
Olufemi Joshua Taiwo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fatal Outcome ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Breast ◽  
Breast Cyst ◽  
Gestational Period ◽  
Pregnancy And Lactation ◽  
Rare Malignancy

Primary squamous cell carcinoma of the breast (SCCB) is a very rare malignancy of the breast and is generally aggressive. It is even rarer during the gestational period. Only few cases have been reported during pregnancy and lactation (Rokutanda et al., 2000). SCCB seen within the gestational period tends to be very aggressive and has a larger size than other breast carcinomas. Pure SCCB is derived from the epidermis of the breast, nipple, or metaplasia on chronic inflammatory background (Bige et al., 2007), such as complicated breast cyst, dermoid cyst, or abscess. We report a case of SCCB in a 30-year-old primigravida that had an aggressive propensity and fatal outcome.

scholarly journals Therapeutic Effect of Combined Dabrafenib and Trametinib Treatment of BRAF V600E-Mutated Primary Squamous Cell Carcinoma of the Thyroid: A Case Report

2021 ◽  
pp. 1-6
Author(s):  
Tim Brandenburg ◽  
Philipp Muchalla ◽  
Sarah Theurer ◽  
Kurt Werner Schmid ◽  
Dagmar Führer
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Male Patient ◽  
Squamous Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Individualized Treatment ◽  
Braf V600e ◽  
Treatment Concept ◽  
Primary Squamous Cell Carcinoma ◽  
Rare Malignancy

<b><i>Introduction:</i></b> Primary squamous cell carcinoma (PSCC) of the thyroid is an exceptionally rare malignancy accounting for &#x3c;1% of all primary thyroid cancers. Therapy is multimodal including surgery, radiotherapy, and chemotherapy but with no consensus for management and therapy. Here, we describe a case of a male patient who presented with a BRAF V600E-mutated PSCC of the thyroid gland showing response to combined dabrafenib and trametinib therapy over a period of &#x3e;12 months. <b><i>Case Presentation:</i></b> A 78-year-old male patient presented with a 3-week history of dysphonia and dyspnoea. Laryngoscopy revealed a mechanical obstruction by a right-sided, subglottical mass, which on cervical ultrasound was highly suggestive of anaplastic thyroid carcinoma. Additional workup including esophagogastroduodenoscopy showed compression of the oesophagus but no oesophageal infiltration by the tumour. Immunohistochemistry displayed CK19-positive cells indicating epithelial origin of the tumour. CK5/6 and P40 immunohistochemistry confirmed the morphological impression of squamous cell differentiation while staining with thyroid markers TTF-1 and TPO was negative and PAX8 showed a nuclear positive signal. Based on immunohistopathology, presence of TP53 and BRAF V600E mutations, and exclusion of metastatic squamous cell carcinoma of other origin, the diagnosis of a PSCC of the thyroid was established. As an individualized treatment concept, we decided to advocate combined BRAF V600E targeting by the multikinase inhibitors dabrafenib and trametinib. This led to drastic improvement in patient’s quality of life without severe side effects over a period of &#x3e;12 months. <b><i>Conclusion:</i></b> In this case, molecular diagnosis allowed a highly individualized treatment concept with combined dabrafenib and trametinib therapy.

scholarly journals Locally Advanced, Unresectable Squamous Cell Carcinoma of the Gallbladder

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Timothy J. Weatherall ◽  
Moon Fenton ◽  
Gitonga Munene ◽  
Paxton V. Dickson ◽  
Jeremiah L. Deneve
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Initial Presentation ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Gallbladder ◽  
Rare Malignancy ◽  
Worse Prognosis

Primary squamous cell carcinoma (SCC) of the gallbladder is a rare malignancy of the gallbladder, accounting for less than 5% of gallbladder pathology. Initial presentation is often similar to adenocarcinoma of the gallbladder. SCC tends to be more locally aggressive, however, and possesses a worse prognosis than adenocarcinoma. We report a case of locally advanced SCC of the gallbladder.

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