scholarly journals Correlation of Papillomacular Nerve Fiber Bundle Thickness with Central Visual Function in Open-Angle Glaucoma

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Wataru Kobayashi ◽  
Hiroshi Kunikata ◽  
Kazuko Omodaka ◽  
Kyousuke Togashi ◽  
Morin Ryu ◽  
...  
Keyword(s):  
Visual Function ◽  
Open Angle Glaucoma ◽  
Automated Perimetry ◽  
Open Angle ◽  
Standard Automated Perimetry ◽  
Macular Diseases ◽  
Highly Correlated ◽  
Two Parameters ◽  
Relationship Of ◽  
Papillomacular Bundle

Purpose. To determine the correlation of reduced retinal thickness in the central papillomacular bundle (CPB) to central visual function, including central retinal sensitivity and visual acuity, in glaucoma patients.Methods. This study enrolled 50 eyes of 50 patients with open-angle glaucoma who were carefully screened for comorbid conditions that can cause decreased central visual function, such as cataracts or macular diseases. We used a novel CPB analysis comprising a program for optical coherence tomography that measured RNFL thickness and GCC thickness in the CPB and divided lengthwise into three parts (upper, middle, and lower CPB). The relationship of these parameters, including conventional macular thickness, to visual field sensitivity in four central standard automated perimetry points (the central four thresholds) and BCVA was analyzed.Results. The two parameters most highly correlated with central four thresholds were macular GCCT and macular RNFLT. The two parameters most highly correlated with BCVA were middle CPB (mid-CPB) GCCT and mid-CPB RNFLT. A multiple regression analysis revealed that mid-CPB GCCT was an independent factor impacting central retinal thresholds and BCVA.Conclusions. Our results suggest that mid-CPB RNFLT and GCCT, parameters of a novel papillomacular bundle analysis, are candidate biomarkers of decreased central visual function in glaucomatous eyes.

scholarly journals Impact of Visual Field Testing on Intraocular Pressure Change Trends in Healthy People and Glaucoma Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Mengwei Li ◽  
Bingxin Zheng ◽  
Qi Wang ◽  
Xinghuai Sun
Keyword(s):  
Intraocular Pressure ◽  
Visual Field ◽  
Repeated Measures ◽  
Healthy Subjects ◽  
Open Angle Glaucoma ◽  
Field Testing ◽  
Automated Perimetry ◽  
Open Angle ◽  
Standard Automated Perimetry ◽  
The Impact

Purpose. To compare the impact of visual field (VF) testing on intraocular pressure (IOP) change trends between healthy subjects and glaucoma patients. Methods. We recruited healthy volunteer subjects who did not have previous ocular diseases and open-angle glaucoma patients who were medically controlled well. IOP in both eyes of each participant was measured by using a noncontact tonometer at five time points: before, immediately after (0 minute), and 10, 30, and 60 minutes after the standard automated perimetry. Repeated measures ANOVA was used to analyze the effect of VF testing on IOP change trends in healthy and glaucoma eyes. Results. Forty healthy subjects (80 eyes) and 31 open-angle glaucoma patients (62 eyes) were included for the study. The baseline IOP of healthy and glaucoma eyes was 16.11 ± 3.01 mmHg and 15.78 ± 3.57 mmHg, respectively. After the VF testing, the IOP in healthy eyes was decreased by 1.5% at 0 minute, 6.5% at 10 minutes (P<0.001), 6.6% at 30 minutes (P<0.001), and 7.0% at 1 hour (P<0.001), indicating that this reduction was sustained for at least 1 hour. However, the IOP in glaucoma eyes was increased by 12.7% at 0 minute (P<0.001) and, then, returned towards initial values 1 hour after the VF testing. Conclusions. IOP change trends after VF field testing between healthy subjects and glaucoma patients were quite different. VF testing led to a mild and relatively sustained IOP decrease in healthy subjects, whereas IOP in open-angle glaucoma patients tended to significantly increase immediately after VF testing and, then, returned to pretest values after 1 hour. These findings indicate that the factors of VF testing should be considered in the clinical IOP measurements.

scholarly journals Short-Term Effect of Standard Automated Perimetry Testing on Intraocular Pressure in Patients with Open-Angle Glaucoma

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Chang Mok Lee ◽  
Young Cheol Yoo
Keyword(s):  
Intraocular Pressure ◽  
Open Angle Glaucoma ◽  
Term Effect ◽  
Mean Deviation ◽  
Test Duration ◽  
Automated Perimetry ◽  
Open Angle ◽  
Standard Automated Perimetry ◽  
Short Term ◽  
Short Term Effect

Purpose. To evaluate the short-term effect of standard automated perimetry (SAP) testing on intraocular pressure (IOP) in patients with open-angle glaucoma (OAG). Methods. We tested 45 patients (71 eyes) with OAG that had stable IOP under medical treatment. IOP was measured four times using an iCare rebound tonometer (RBT) immediately before, immediately after, 10 minutes after, and 20 minutes after SAP testing. Logistic regression analyses were performed to determine the relationships among SAP test duration, mean deviation of the SAP result, type of glaucoma medications, patient age, and significant IOP change (exceeding 2 mmHg) from baseline IOP. Results. The mean baseline IOP was 13.29 ± 3.06 mmHg. Although IOP changes immediately and 20 minutes after SAP testing were not statistically significant, the IOP change 10 minutes after SAP testing (−0.57 ± 1.84 mmHg) was statistically significant. However, the changes were within the margin of error of the RBT. Test duration, mean deviation, patient age, and type of glaucoma medications did not have a significant influence on IOP change (all ). Conclusions. IOP measured by RBT did not vary significantly after SAP testing in patients with OAG. It may be not necessary to reject IOP measured after SAP testing in patients with OAG.

Relationship of Cerebral Blood Flow and Central Visual Function in Primary Open-angle Glaucoma

2007 ◽  
Vol 16 (1) ◽  
pp. 159-163 ◽  
Author(s):  
Alon Harris ◽  
Brent Siesky ◽  
Drora Zarfati ◽  
Charles L. Haine ◽  
Yara Catoira ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Visual Function ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Relationship Of

scholarly journals Computer perimetry in the diagnosis of primary open-angle glaucoma

2018 ◽  
Vol 11 (1) ◽  
pp. 54-65 ◽  
Author(s):  
Svetlana A Serdyukova ◽  
Irina L Simakova
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Automated Perimetry ◽  
Open Angle ◽  
Static Perimetry ◽  
Standard Automated Perimetry ◽  
Russian Market ◽  
Glaucoma Diagnosis ◽  
Modern Methods ◽  
Computerized Perimetry

Static perimetry, made using Humphrey and Octopus expert class perimeters, is called the standard automated perimetry (SAP); and for more than 30 years, it is the “gold standard” in assessing the visual field in glaucoma diagnosis. Currently, many computer perimeters appeared on the Russian market. The article reviews modern methods of computerized perimetry which are most widespread in our country and presents their comparative characteristics. (For citation: Serdyukova SA, Simakova IL. Computer perimetry in the diagnosis of primary open-angle glaucoma. Ophthalmology Journal. 2018;11(1):54-65. doi: 10.17816/OV11154-65).

scholarly journals Relationship between visual field changes and optical coherence tomography measurements in advanced open-angle glaucoma

Folia Medica ◽  
2016 ◽  
Vol 58 (3) ◽  
pp. 174-181 ◽  
Author(s):  
Snezhina S. Kostianeva ◽  
Marieta I. Konareva-Kostianeva ◽  
Marin A. Atanassov
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Structural Changes ◽  
Open Angle Glaucoma ◽  
Mean Deviation ◽  
Ganglion Cell Complex ◽  
Automated Perimetry ◽  
Optical Coherence ◽  
Open Angle ◽  
Sd Oct

Abstract Aim: To assess relationships between functional changes in visual field and structural changes in advanced open-angle glaucoma (OAG) found using spectral-domain optical coherence tomography (SD-OCT). Methods: Thirty-one eyes of 25 patients with OAG were included in this study. Besides the routine ophthalmological exam the patients underwent standard automated perimetry (SAP) (Humphrey Field Analyzer) and SD-OCT (RTVue–100) performed within 6 months. The global perimetric indices in the study group were as follows: mean deviation (MD) 12.33±6.18 dB and pattern standard deviation (PSD) 9.17±3.41 dB. The relationship between OCT measurements and MD and PSD was evaluated by correlation analysis (Pearson’s correlation coefficient) and regression analysis (linear and nonlinear regression models). Results: Thickness measurements of the lower halves of ganglion cell complex (GCC) and retinal nerve fiber layer by two scanning protocols (ONH and 3.45) showed these to be thinner than the upper halves, but the difference failed to reach statistical significance. The correlations between global indices MD/PSD and most of the analysed quantitative OCT measurements were moderate (r in the range between 0.3 and 0.6). The correlation between MD and GCC showed nonlinear cubic regression (R2=0.417, P=0.004). Good correlation was found between MD and GLV (R2=0.383; P=0.008). Linear regression (P<0.05) was found only between MD and Cup area (R2=0.175, P=0.024) and between MD and RNFL by 3.45 protocol (R2=0.131, P=0.045). Conclusion: Nonlinear regressive models appear to be more appropriate in the assessment of the correlations between functional and structural changes in eyes with advanced glaucoma. The correlations we found were moderate.

scholarly journals Relationship of the 24-Hour Pattern of Intraocular Pressure with Optic Disc Appearance in Primary Open-Angle Glaucoma

Ophthalmology ◽  
2009 ◽  
Vol 116 (5) ◽  
pp. 833-839 ◽  
Author(s):  
Sunil P. Deokule ◽  
Amish Doshi ◽  
Gianmarco Vizzeri ◽  
Felipe A. Medeiros ◽  
John H.K. Liu ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Disc ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Relationship Of

Comparison of vascular–function and structure–function correlations in glaucomatous eyes with high myopia

2019 ◽  
Vol 104 (6) ◽  
pp. 807-812
Author(s):  
Seung Hyen Lee ◽  
Eun Ji Lee ◽  
Tae-Woo Kim
Keyword(s):  
Visual Field ◽  
Vascular Function ◽  
High Myopia ◽  
Open Angle Glaucoma ◽  
Retinal Vessel ◽  
Retinal Nerve Fibre Layer ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Cross Sectional ◽  
Visual Field Damage

Background/aimsTo determine the usefulness of peripapillary retinal vessel density (VD) measured using optical coherence tomography (OCT) angiography (OCTA) in the evaluation of glaucomatous visual field damage in highly myopic eyes with primary open-angle glaucoma (POAG).MethodsThis cross-sectional observational study enrolled a total of 124 myopic POAG eyes consisting of 40 eyes showing a segmentation error (SE) in OCT scans and 84 eyes without an SE. The peripapillary retinal VD, circumpapillary retinal nerve fibre layer thickness (RNFLT) and visual field sensitivity loss (VFSL) were assessed using OCTA, spectral-domain OCT and standard automated perimetry, respectively. The topographical correlations between the VD and VFSL, and between the RNFLT and VFSL were determined in subgroups divided according to the presence of an SE.ResultsThe peripapillary retinal VD showed significant topographical correlation with VFSL both in the highly myopic POAG eyes without an SE globally (R=0.527, p<0.001), and in temporal (R=0.593), temporal-superior (R=0.543), nasal-inferior (R=0.422) and temporal-inferior sectors (R=0.600, all p<0.001), and in those with an SE globally (R=0.343, p=0.030), and in temporal (R=0.494, p=0.001), temporal-superior (R=0.598, p<0.001), and temporal-inferior sectors (R=0.424, p=0.006). The correlation with VFSL did not differ between the VD and RNFLT in the eyes without an SEConclusionPeripapillary VD as measured with OCTA showed a topographical correlation with VFSL in highly myopic POAG eyes regardless of the presence of an OCT SE OCTA may be a useful adjunct for evaluating glaucomatous visual field damage in high myopia, where the OCT results are frequently confounding.

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