Impact of Visual Field Testing on Intraocular Pressure Change Trends in Healthy People and Glaucoma Patients

Purpose. To compare the impact of visual field (VF) testing on intraocular pressure (IOP) change trends between healthy subjects and glaucoma patients. Methods. We recruited healthy volunteer subjects who did not have previous ocular diseases and open-angle glaucoma patients who were medically controlled well. IOP in both eyes of each participant was measured by using a noncontact tonometer at five time points: before, immediately after (0 minute), and 10, 30, and 60 minutes after the standard automated perimetry. Repeated measures ANOVA was used to analyze the effect of VF testing on IOP change trends in healthy and glaucoma eyes. Results. Forty healthy subjects (80 eyes) and 31 open-angle glaucoma patients (62 eyes) were included for the study. The baseline IOP of healthy and glaucoma eyes was 16.11 ± 3.01 mmHg and 15.78 ± 3.57 mmHg, respectively. After the VF testing, the IOP in healthy eyes was decreased by 1.5% at 0 minute, 6.5% at 10 minutes (P<0.001), 6.6% at 30 minutes (P<0.001), and 7.0% at 1 hour (P<0.001), indicating that this reduction was sustained for at least 1 hour. However, the IOP in glaucoma eyes was increased by 12.7% at 0 minute (P<0.001) and, then, returned towards initial values 1 hour after the VF testing. Conclusions. IOP change trends after VF field testing between healthy subjects and glaucoma patients were quite different. VF testing led to a mild and relatively sustained IOP decrease in healthy subjects, whereas IOP in open-angle glaucoma patients tended to significantly increase immediately after VF testing and, then, returned to pretest values after 1 hour. These findings indicate that the factors of VF testing should be considered in the clinical IOP measurements.

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Compass fundus automated perimetry

European Journal of Ophthalmology ◽

10.1177/1120672118757667 ◽

2018 ◽

Vol 28 (5) ◽

pp. 481-490 ◽

Cited By ~ 1

Author(s):

Paolo Fogagnolo ◽

Maurizio Digiuni ◽

Giovanni Montesano ◽

Chiara Rui ◽

Marco Morales ◽

...

Keyword(s):

Visual Field ◽

Visual Fields ◽

Field Testing ◽

Automated Perimetry ◽

Standard Automated Perimetry ◽

Gaze Tracking ◽

Intrinsic Factors ◽

Global Indices ◽

Humphrey Field Analyzer ◽

The Impact

Background: Compass (CenterVue, Padova, Italy) is a fundus automated perimeter which has been introduced in the clinical practice for glaucoma management in 2014. The aim of the article is to review Compass literature, comparing its performances against Humphrey Field Analyzer (Zeiss Humphrey Systems, Dublin, CA, USA). Results: Analyses on both normal and glaucoma subjects agree on the fact that Humphrey Field Analyzer and Compass are interchangeable, as the difference of their global indices is largely inferior than test -retest variability for Humphrey Field Analyzer. Compass also enables interesting opportunities for the assessment of morphology, and the integration between morphology and function on the same device. Conclusion: Visual field testing by standard automated perimetry is limited by a series of intrinsic factors related to the psychophysical nature of the examination; recent papers suggest that gaze tracking is closely related to visual field reliability. Compass, thanks to a retinal tracker and to the active dislocation of stimuli to compensate for eye movements, is able to provide visual fields unaffected by fixation instability. Also, the instrument is a true colour, confocal retinoscope and obtains high-quality 60° × 60° photos of the central retina and stereo-photos details of the optic nerve. Overlapping the image of the retina to field sensitivity may be useful in ascertaining the impact of comorbidities. In addition, the recent introduction of stereoscopic photography may be very useful for better clinical examination.

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Influence of automated visual field testing on intraocular pressure

10.21203/rs.3.rs-21287/v1 ◽

2020 ◽

Author(s):

Samuel Bertaud ◽

Elisabeth Skarbek Borowski ◽

Rachid Abbas ◽

Christophe Baudouin ◽

Antoine Labbé

Keyword(s):

Intraocular Pressure ◽

Visual Field ◽

Open Angle Glaucoma ◽

Corneal Thickness ◽

Angle Closure ◽

Mean Deviation ◽

Test Duration ◽

Automated Perimetry ◽

Significant Difference ◽

The Impact

Abstract Background To evaluate the influence of automated visual field (VF) testing on intraocular pressure (IOP) in patients with ocular hypertension (OHT) or glaucoma. Methods We conducted a prospective observational study from October 2015 to July 2016 at Quinze-Vingts National Ophthalmology Hospital in Paris. Ninety-five right eyes of 95 patients followed for glaucoma or OHT with reliable standard automated perimetry (SAP) were included. IOP was measured three times using a Nidek NT-510 non-contact tonometer within a maximum of 5 minutes before and after VF testing. Subanalyses using logistic regression analysis were performed to evaluate the impact of gender, age, central corneal thickness (CCT), mean deviation (MD) of the VF, VF test duration and filtration surgery on IOP fluctuations. Results There was no significant change in IOP after VF testing, with IOP’s 15.14 ± 4.00 mmHg before and 14.98 ± 3.33 mmHg after the VF (P = 0.4). The average change in IOP was 0.15 ± 1.82 mmHg. Using multivariate analysis, no effect of the VF test on IOP was found (global model fit R²=0.12), whether based on duration of the VF test (P = 0.18) or the MD (P = 0.7) after adjustment for age, gender, CCT and history of glaucoma surgery. Similarly, there was no significant difference within different types of glaucoma, including open-angle glaucoma (p = 0.36), chronic angle closure glaucoma (P = 0.85) and OHT (P = 0.42). The subgroup of patients with an IOP elevation > 2 mmHg had a significantly higher SAP test duration (P = 0.002). Conclusion VF testing by SAP does not influence IOP as measured with a non-contact tonometer.

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Comparing the efficacy of trabeculectomy and XEN gel microstent implantation for the treatment of primary open-angle glaucoma: a retrospective monocentric comparative cohort study

Scientific Reports ◽

10.1038/s41598-020-76551-y ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Theresa Theilig ◽

Matus Rehak ◽

Catharina Busch ◽

Caroline Bormann ◽

Marc Schargus ◽

...

Keyword(s):

Visual Field ◽

Open Angle Glaucoma ◽

Statistical Significance ◽

Field Testing ◽

Automated Perimetry ◽

Open Angle ◽

Comparable Group ◽

Comparative Cohort Study ◽

Visual Field Indices

Abstract The aim of this study was to compare the efficacy and safety profile of XEN microstent implantation with trabeculectomy (TET) in a comparable group of open-angle glaucoma cases in a retrospective, monocentric, single-surgeon setting. Each treatment group consisted of 100 eyes of 100 patients. At regular follow-up visits during the first 12 months after surgery, the following assessments were conducted and compared: intraocular pressure (IOP), number of IOP-lowering medications applied, best-corrected visual acuity (BCVA) and visual field testing. In both groups mean IOP was significantly reduced (p < 0.001). Mean IOP dropped from 24.8 ± 7.8 to 14.8 ± 4.0 mmHg in the TET and from 24.5 ± 6.7 to 16.6 ± 4.8 mmHg in the XEN group. The number of active compounds in the prescribed medication dropped from 3.3 ± 1.2 to 1.3 ± 1.4 in the TET and from 3.0 ± 1.1 to 1.4 ± 1.5 in the XEN group. BCVA and mean defect of static automated perimetry did not show a change of statistical significance in either group. Complications were more frequent after TET (p = 0.005) while postoperative needling was more frequent in the XEN group (p = 0.021). TET and XEN led to a significant reduction of IOP and IOP-lowering medication, while BCVA and visual field indices remained mostly unaltered over a 12-month postsurgical follow-up.

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Short-Term Effect of Standard Automated Perimetry Testing on Intraocular Pressure in Patients with Open-Angle Glaucoma

ISRN Ophthalmology ◽

10.1155/2013/956504 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Chang Mok Lee ◽

Young Cheol Yoo

Keyword(s):

Intraocular Pressure ◽

Open Angle Glaucoma ◽

Term Effect ◽

Mean Deviation ◽

Test Duration ◽

Automated Perimetry ◽

Open Angle ◽

Standard Automated Perimetry ◽

Short Term ◽

Short Term Effect

Purpose. To evaluate the short-term effect of standard automated perimetry (SAP) testing on intraocular pressure (IOP) in patients with open-angle glaucoma (OAG). Methods. We tested 45 patients (71 eyes) with OAG that had stable IOP under medical treatment. IOP was measured four times using an iCare rebound tonometer (RBT) immediately before, immediately after, 10 minutes after, and 20 minutes after SAP testing. Logistic regression analyses were performed to determine the relationships among SAP test duration, mean deviation of the SAP result, type of glaucoma medications, patient age, and significant IOP change (exceeding 2 mmHg) from baseline IOP. Results. The mean baseline IOP was 13.29 ± 3.06 mmHg. Although IOP changes immediately and 20 minutes after SAP testing were not statistically significant, the IOP change 10 minutes after SAP testing (−0.57 ± 1.84 mmHg) was statistically significant. However, the changes were within the margin of error of the RBT. Test duration, mean deviation, patient age, and type of glaucoma medications did not have a significant influence on IOP change (all ). Conclusions. IOP measured by RBT did not vary significantly after SAP testing in patients with OAG. It may be not necessary to reject IOP measured after SAP testing in patients with OAG.

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Relationship between Postural Change of the Intraocular Pressure and Visual Field Loss in Primary Open-Angle Glaucoma

Journal of Glaucoma ◽

10.1097/00061198-200308000-00015 ◽

2003 ◽

Vol 12 (4) ◽

pp. 379-382 ◽

Cited By ~ 46

Author(s):

Kazuyuki Hirooka ◽

Fumio Shiraga

Keyword(s):

Intraocular Pressure ◽

Visual Field ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Visual Field Loss ◽

Open Angle ◽

Postural Change

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Interocular Asymmetry of Visual Field Loss, Intraocular Pressure and Corneal Parameters in Primary Open-angle Glaucoma

Ophthalmic Research ◽

10.1159/000510716 ◽

2020 ◽

Author(s):

Junhong Jiang ◽

xiafei pan ◽

Zhong Lin ◽

Nived Moonasar ◽

cong ye ◽

...

Keyword(s):

Intraocular Pressure ◽

Visual Field ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Visual Field Loss ◽

Open Angle

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Intraocular Pressure and the Rate of Visual Field Loss in Chronic Open-Angle Glaucoma

American Journal of Ophthalmology ◽

10.1016/s0002-9394(14)72386-4 ◽

1991 ◽

Vol 111 (4) ◽

pp. 491-500 ◽

Cited By ~ 93

Author(s):

Colm O'Brien ◽

Bernard Schwartz ◽

Takenori Takamoto ◽

Da Ching Wu

Keyword(s):

Intraocular Pressure ◽

Visual Field ◽

Open Angle Glaucoma ◽

Visual Field Loss ◽

Open Angle ◽

Chronic Open Angle Glaucoma

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Relationship between visual field changes and optical coherence tomography measurements in advanced open-angle glaucoma

Folia Medica ◽

10.1515/folmed-2016-0027 ◽

2016 ◽

Vol 58 (3) ◽

pp. 174-181 ◽

Cited By ~ 2

Author(s):

Snezhina S. Kostianeva ◽

Marieta I. Konareva-Kostianeva ◽

Marin A. Atanassov

Keyword(s):

Optical Coherence Tomography ◽

Visual Field ◽

Structural Changes ◽

Open Angle Glaucoma ◽

Mean Deviation ◽

Ganglion Cell Complex ◽

Automated Perimetry ◽

Optical Coherence ◽

Open Angle ◽

Sd Oct

Abstract Aim: To assess relationships between functional changes in visual field and structural changes in advanced open-angle glaucoma (OAG) found using spectral-domain optical coherence tomography (SD-OCT). Methods: Thirty-one eyes of 25 patients with OAG were included in this study. Besides the routine ophthalmological exam the patients underwent standard automated perimetry (SAP) (Humphrey Field Analyzer) and SD-OCT (RTVue–100) performed within 6 months. The global perimetric indices in the study group were as follows: mean deviation (MD) 12.33±6.18 dB and pattern standard deviation (PSD) 9.17±3.41 dB. The relationship between OCT measurements and MD and PSD was evaluated by correlation analysis (Pearson’s correlation coefficient) and regression analysis (linear and nonlinear regression models). Results: Thickness measurements of the lower halves of ganglion cell complex (GCC) and retinal nerve fiber layer by two scanning protocols (ONH and 3.45) showed these to be thinner than the upper halves, but the difference failed to reach statistical significance. The correlations between global indices MD/PSD and most of the analysed quantitative OCT measurements were moderate (r in the range between 0.3 and 0.6). The correlation between MD and GCC showed nonlinear cubic regression (R2=0.417, P=0.004). Good correlation was found between MD and GLV (R2=0.383; P=0.008). Linear regression (P<0.05) was found only between MD and Cup area (R2=0.175, P=0.024) and between MD and RNFL by 3.45 protocol (R2=0.131, P=0.045). Conclusion: Nonlinear regressive models appear to be more appropriate in the assessment of the correlations between functional and structural changes in eyes with advanced glaucoma. The correlations we found were moderate.

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