scholarly journals Efficacy and Interindividual Variability in Motor-Cortex Plasticity following Anodal tDCS and Paired-Associative Stimulation

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Wolfgang Strube ◽  
Tilmann Bunse ◽  
Berend Malchow ◽  
Alkomiet Hasan
Keyword(s):  
Motor Cortex ◽  
Cortical Excitability ◽  
Response Variability ◽  
Significant Group ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Excitability Change ◽  
Human Motor ◽  
Baseline Values

Interindividual response variability to various motor-cortex stimulation protocols has been recently reported. Comparative data of stimulation protocols with different modes of action is lacking. We aimed to compare the efficacy and response variability of two LTP-inducing stimulation protocols in the human motor cortex: anodal transcranial direct current stimulation (a-tDCS) and paired-associative stimulation (PAS25). In two experiments 30 subjects received 1mA a-tDCS and PAS25. Data analysis focused on motor-cortex excitability change and response defined as increase in MEP applying different cut-offs. Furthermore, the predictive pattern of baseline characteristics was explored. Both protocols induced a significant increase in motor-cortical excitability. In the PAS25 experiments the likelihood to develop a MEP response was higher compared to a-tDCS, whereas for intracortical facilitation (ICF) the likelihood for a response was higher in the a-tDCS experiments. Baseline ICF (12 ms) correlated positively with an increase in MEPs only following a-tDCS and responders had significantly higher ICF baseline values. Contrary to recent studies, we showed significant group-level efficacy following both stimulation protocols confirming older studies. However, we also observed a remarkable amount of nonresponders. Our findings highlight the need to define sufficient physiological read-outs for a given plasticity protocol and to develop predictive markers for targeted stimulation.

scholarly journals Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation

2002 ◽  
Vol 543 (2) ◽  
pp. 699-708 ◽  
Author(s):  
Katja Stefan ◽  
Erwin Kunesch ◽  
Reiner Benecke ◽  
Leonardo G. Cohen ◽  
Joseph Classen
Keyword(s):  
Motor Cortex ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Human Motor

P025 Minocycline has acute inhibitory effects on human motor cortex excitability

2008 ◽  
Vol 119 ◽  
pp. S77
Author(s):  
Nicolas Lang ◽  
Daniella Terney ◽  
Holger Rothkegel ◽  
Andrea Antal ◽  
Walter Paulus
Keyword(s):  
Motor Cortex ◽  
Inhibitory Effects ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Human Motor

scholarly journals High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions

2022 ◽  
Vol 15 ◽  
Author(s):  
Ru Ma ◽  
Xinzhao Xia ◽  
Wei Zhang ◽  
Zhuo Lu ◽  
Qianying Wu ◽  
...  
Keyword(s):  
Reaction Time ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Reaction Time Task ◽  
Promoting Effect ◽  
Motor Functions ◽  
Human Motor Cortex ◽  
Time Task ◽  
Motor Cortex Excitability ◽  
Human Motor

Background: Temporal interference (TI) stimulation is a new technique of non-invasive brain stimulation. Envelope-modulated waveforms with two high-frequency carriers can activate neurons in target brain regions without stimulating the overlying cortex, which has been validated in mouse brains. However, whether TI stimulation can work on the human brain has not been elucidated.Objective: To assess the effectiveness of the envelope-modulated waveform of TI stimulation on the human primary motor cortex (M1).Methods: Participants attended three sessions of 30-min TI stimulation during a random reaction time task (RRTT) or a serial reaction time task (SRTT). Motor cortex excitability was measured before and after TI stimulation.Results: In the RRTT experiment, only 70 Hz TI stimulation had a promoting effect on the reaction time (RT) performance and excitability of the motor cortex compared to sham stimulation. Meanwhile, compared with the sham condition, only 20 Hz TI stimulation significantly facilitated motor learning in the SRTT experiment, which was significantly positively correlated with the increase in motor evoked potential.Conclusion: These results indicate that the envelope-modulated waveform of TI stimulation has a significant promoting effect on human motor functions, experimentally suggesting the effectiveness of TI stimulation in humans for the first time and paving the way for further explorations.

Dopaminergic modulation of long-lasting direct current-induced cortical excitability changes in the human motor cortex

2006 ◽  
Vol 23 (6) ◽  
pp. 1651-1657 ◽  
Author(s):  
Michael A. Nitsche ◽  
Christian Lampe ◽  
Andrea Antal ◽  
David Liebetanz ◽  
Nicolas Lang ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Direct Current ◽  
Cortical Excitability ◽  
Human Motor Cortex ◽  
Dopaminergic Modulation ◽  
Human Motor

Influence of (S)-ketamine on human motor cortex excitability

2012 ◽  
Vol 225 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Oliver Höffken ◽  
Ida S. Haussleiter ◽  
Andrea Westermann ◽  
Jörn Lötsch ◽  
Christoph Maier ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Human Motor

scholarly journals Effect of Serotonin on Paired Associative Stimulation-Induced Plasticity in the Human Motor Cortex

2013 ◽  
Vol 38 (11) ◽  
pp. 2260-2267 ◽  
Author(s):  
Giorgi Batsikadze ◽  
Walter Paulus ◽  
Min-Fang Kuo ◽  
Michael A Nitsche
Keyword(s):  
Motor Cortex ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Human Motor

Visual deprivation effects on human motor cortex excitability

2005 ◽  
Vol 389 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Fidias E. Leon-Sarmiento ◽  
William Bara-Jimenez ◽  
Eric M. Wassermann
Keyword(s):  
Motor Cortex ◽  
Visual Deprivation ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Human Motor

NMDA Receptor-Mediated Motor Cortex Plasticity After 20 Hz Transcranial Alternating Current Stimulation

2018 ◽  
Vol 29 (7) ◽  
pp. 2924-2931 ◽  
Author(s):  
M Wischnewski ◽  
M Engelhardt ◽  
M A Salehinejad ◽  
D J L G Schutter ◽  
M -F Kuo ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Cortical Excitability ◽  
Alternating Current ◽  
Beta Oscillations ◽  
Human Motor Cortex ◽  
After Effects ◽  
Transcranial Alternating Current Stimulation ◽  
Human Motor ◽  
Motor Cortex Plasticity

Abstract Transcranial alternating current stimulation (tACS) has been shown to modulate neural oscillations and excitability levels in the primary motor cortex (M1). These effects can last for more than an hour and an involvement of N-methyl-d-aspartate receptor (NMDAR) mediated synaptic plasticity has been suggested. However, to date the cortical mechanisms underlying tACS after-effects have not been explored. Here, we applied 20 Hz beta tACS to M1 while participants received either the NMDAR antagonist dextromethorphan or a placebo and the effects on cortical beta oscillations and excitability were explored. When a placebo medication was administered, beta tACS was found to increase cortical excitability and beta oscillations for at least 60 min, whereas when dextromethorphan was administered, these effects were completely abolished. These results provide the first direct evidence that tACS can induce NMDAR-mediated plasticity in the motor cortex, which contributes to our understanding of tACS-induced influences on human motor cortex physiology.

Sign in / Sign up

Export Citation Format

Share Document