FORMULATION, OPTIMIZATION, AND CHARACTERIZATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS CONTAINING EPLERENONE

Objective: The proposed work was aimed at optimization, formulation, and characterization of transdermal patches of eplerenone for efficient transdermal delivery of the drug. Methods: The log p estimation of eplerenone is 1.34, it was closer to standard worth. Log P value in a range of 1 to 4 indicates higher permeation through the skin. FTIIR study was carried out individually for drug, each polymer, and finished product (Patches) compared eplerenone and FTIR spectra of pure drug and polymer. The calibration curve of eplerenone in Phosphate buffer pH 6.8 was analyzed. Results: The selected range of eplerenone was found to be linear. A regression coefficient (R2) at 245 nm was found to be 0.994. Drug content outcomes additionally discovered uniform in all clusters in a range of 97 % to 98 %, that batches arranged with ERS 100 show great mechanical properties contrast with different polymers however helpless glue properties. The flatness of 4 cm2 patches ranges from 348±0.087 mg to 387±0.527 mg. skin irritation it was produced irritation with negligible erythema following 10 d and unequivocal erythema, promptly obvious edema was produced following 12 d. Conclusion: These after-effects of the in vivo skin irritation study recommended that advanced batch S9 doesn't show any kind of significant disturbance on rodent skin for as long as 14 d and it was securely utilized around 24 h. the optimized batch S9 drug was constantly discharged through the Wistar rodent skin up to 16 hr and the delivery design was like an in vitro dissolution profile of the market product.

Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome

Rosemary (Rosmarinus officinalis [family Lamiaceae]), an herb of economic and gustatory repute, is employed in traditional medicines in many countries. Rosemary contains carnosic acid (CA) and carnosol (CS), abietane-type phenolic diterpenes, which account for most of its biological and pharmacological actions, although claims have also been made for contributions of another constituent, rosmarinic acid. This review focuses on the potential applications of CA and CS for Alzheimer’s disease (AD), Parkinson’s disease (PD), and coronavirus disease 2019 (COVID-19), in part via inhibition of the NLRP3 inflammasome. CA exerts antioxidant, anti-inflammatory, and neuroprotective effects via phase 2 enzyme induction initiated by activation of the KEAP1/NRF2 transcriptional pathway, which in turn attenuates NLRP3 activation. In addition, we propose that CA-related compounds may serve as therapeutics against the brain-related after-effects of SARS-CoV-2 infection, termed “long-COVID.” One factor that contributes to COVID-19 is cytokine storm emanating from macrophages as a result of unregulated inflammation in and around lung epithelial and endovascular cells. Additionally, neurological aftereffects such as anxiety and “brain fog” are becoming a major issue for both the pandemic and post-pandemic period. Many reports hold that unregulated NLRP3 inflammasome activation may potentially contribute to the severity of COVID-19 and its aftermath. It is therefore possible that suppression of NLRP3 inflammasome activity may prove efficacious against both acute lung disease and chronic neurological after-effects. Because CA has been shown to not only act systemically but also to penetrate the blood–brain barrier and reach the brain parenchyma to exert neuroprotective effects, we discuss the evidence that CA or rosemary extracts containing CA may represent an effective countermeasure against both acute and chronic pathological events initiated by SARS-CoV-2 infection as well as other chronic neurodegenerative diseases including AD and PD.

PELATIHAN AFTER EFECTS UNTUK MENINGKATKAN KREATIFITAS SISWA JURUSAN MULTIMEDIA SMK MUHAMMADIYAH 2 PEKANBARU

Abstrak: After Effects salah satu software efek digital visual, grafis gerak, dan aplikasi compositing yang dikembangkan oleh Adobe Systems dan digunakan dalam proses pasca produksi pembuatan film dan produksi televisi. After Effects dapat digunakan untuk memasukkan, melacak, rotoscoping, compositing dan animasi. Kegiatan pelatihan ini ditujukan pada siswa –siswi SMK Muhammadiyah 2 Pekanbaru jurusan Multimedia. Siswa diberikan materi dari konsep pengembangan multimedia, pengenalan after effects, pengenalan tool, project opening, animasi teks dan mini kompetisi multimedia. Dengan adanya pelatihan ini akan meningkatkan kreatifitas multimedia untuk menjadi bekal siswa dalam menghadapi magang dan Ujian Keahlian Kompetensi (UKK). Kata Kunci: After Effects, Multimedia, SMK Muhammadiyah 2 Pekanbaru Abstract: After Effects is a digital visual effects software, motion graphics, and compositing application developed by Adobe Systems and used in the post-production process of filmmaking and television production. After Effects can be used for inserting, tracing, rotoscoping, compositing and animation. This training activity is aimed at students of SMK Muhammadiyah 2 Pekanbaru majoring in Multimedia. Students are given material from the concept of multimedia development, introduction to after effects, introduction to tools, project opening, text animation and multimedia mini competition. With this training, it will increase multimedia creativity to equip students to face internships and the Competency Skills Exam (UKK). Keywords: After Effects, Multimedia, SMK Muhammadiyah 2 Pekanbaru

Wearable Hand-Rehabilitation System with Soft Gloves for Patient with Face Paralysis and Disability

Artificially intelligent advances such as tech gloves allow handicapped wearers to handle daily matters as normal. A wearable hand-rehabilitation system, i.e., a robotic arm, is engineered with controlled programming to control a disabled hand with features such as movement of fingers and holding items. A life-threatening disease (stroke) is caused when brain cells start to die, causing around 50–70% of patients to face paralysis and disability. People may face after-effects such as reduced use of the hand and limb or a paralyzed hand. Many methods have been introduced to overcome these issues, including therapies, but they are not so reliable when overcoming disability issues. To overcome these issues, we proposed a smart robotic hand that encounters hand disability issues. The smart robotic hand will aid the hands of disabled people by replacing their disabled hand with the smart robotic hand and by controlling the movement of the robot with the movement of the other hand. This can also be helpful for environments where it is not feasible for humans to work, such as in nuclear reactors and in bomb disposal squads. Some people have disabilities of the hand, so this smart robotic hand can also be used in that scenario. The robotic hand is mainly controlled through a flex sensor. By using Arduino, flex sensor outputs are mapped accordingly to the servo motors. The robot is controlled by a wired arrangement.

Identifying the Perspectives of Domestic Tourists Visiting Puducherry of India During the COVID-19 Pandemic

A fishbone diagram was used in this study to identify the perspectives of Indian tourists who visited Puducherry during the COVID-19 pandemic. The main problems encountered by the tourists who visited Puducherry were personal problems and issues related to food and accommodations, transportation, lockdown after effects, government regulations and territorial restrictions. Tourism authorities and local governments should consider and solve the problems identified by the tourists to boost the local economy to attract domestic tourists during the ongoing pandemic.

RECURSOS AUDIOVISUAIS COMO ESTRATÉGIA DE COMUNICAÇÃO PARA ABORDAR O TEMA SEGURANÇA DO PACIENTE.

Introdução: Segurança do Paciente é uma dimensão da qualidade que envolve o cumprimento de Boas Práticas nos Serviços de Saúde. Porém, incidentes podem ocorrer, sendo necessário que os órgãos sanitários sejam notificados de suas ocorrências. Para ampliar a divulgação do portal de notificação do módulo cidadão da Anvisa, foi produzido um vídeo na disciplina de Educação e Comunicação na Vigilância em Saúde do Programa de Pós-Graduação em Ciências da Coordenadoria de Controle de Doenças, que compôs o processo avaliativo da disciplina. Objetivo: O objetivo do projeto foi desenvolver um produto audiovisual voltado à população que utiliza os serviços de saúde, com o intuito de orientar e estimular a notificação dos incidentes/Eventos Adversos no portal da Anvisa. Material e métodos: Foi proposta uma produção audiovisual, com uma linguagem informal direcionada a sociedade para que possam compreender o acesso e a importância do uso da ferramenta para notificação de incidentes. Com relação a edição do vídeo, foram utilizadas as ferramentas: Illustrator e After Effects. Resultados: Foi produzido um vídeo com 04:11 minutos, com diálogos entre dois personagens ilustrativos e uma narração. Também foi criado um logotipo para a Segurança do Paciente e um QR Code para facilitar o acesso ao site. O material produzido apresenta qualidade de informação, agregada ao uso da tecnologia educacional. A produção fortaleceu e qualificou o trabalho em equipe. Conclusão: O vídeo possui uma linguagem agradável e objetiva, que transmite as informações necessárias para que o cidadão compreenda a importância da notificação. O principal desafio enfrentado foi a adequação destas informações para uma linguagem acessível para o público alvo.

The changing face of contemporary translation studies through polydisciplinary lenses: Possibilities and caveats

This paper offers a meta-reflection of contemporary translation studies (TS) through tracing its polydisciplinary tensions which are approached as both formative forces as well as hindrances. Taking a form of an argumentative essay employing the methods of a reflexive introspection, synthesis and evaluation, the principal aim is to address the potentials and controversies in present-day TS which are connected to its polydisciplinarity. This is a result from the aftermath of Snell-Hornbys integrated approach (1988/1995), TSs cultural and ideological turns as well as cognitive, sociological, anthropological, technological and economic twists. Four major strands of the consequences of the polydisciplinarity in TS are addressed: (a) the clash between the focus on the epistemological core of TS as an antidote to the expanding boundaries of the meta-discipline and embrace of reciprocal interdisciplinarity; (b) the tension between academia as Ivory Tower and practice-minded language industry; (c) the diffusion of the outer boundaries of TS and erasure of its inner boundaries; (d) a multitude of different conceptualizations of TS foregrounding either the abstract or practical. Following TSs inward orientations, two outward turns are suggested, i.e. promoting its relevance to other disciplines and reaching out to translation practice, in tune with Zwischenbergers approach (2019). A continuation of the outward turns may be seen in Gentzlers post-translation studies focusing on the study of pre-translation culture and after-effects of translation in the target culture. Although the paper does not tend to conceptual extremes, it suggests that authentic transdisciplinary TS should be mindful of a constructive and mutually enriching dialogue with donor disciplines and interlacement between theory and practice, with a focus on real-world issues, becomes imperative in order to make TS viable.

Navigating the "COVID hangover" in physiology courses

Undergraduate educators and students must navigate lingering after-effects of the COVID pandemic on education in the 2021-2022 academic year even as COVID continues to impact delivery of undergraduate science education. This article describes ongoing difficulties for undergraduate STEM students and educators and suggests strategies and easy-to-use resources that may help educators navigate the "COVID hangover" and ongoing COVID-related disruptions.