scholarly journals Mucoepidermoid Carcinoma Associated with Osteosarcoma in a True Malignant Mixed Tumor of the Submandibular Region

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Dario Marcotullio ◽  
Marco de Vincentiis ◽  
Giannicola Iannella ◽  
Bruna Cerbelli ◽  
Giuseppe Magliulo
Keyword(s):  
Submandibular Gland ◽  
Mucoepidermoid Carcinoma ◽  
De Novo ◽  
High Grade ◽  
Mixed Tumor ◽  
Submandibular Region ◽  
Case Presentation ◽  
First Case ◽  
Malignant Mixed Tumor ◽  
Benign Mixed Tumor

Introduction. True malignant mixed tumor, also known as carcinosarcoma, is a rare tumor of the salivary gland composed of both malignant epithelial and malignant mesenchymal elements. Frequently carcinosarcoma arises in the background of a preexisting pleomorphic adenoma; however, if no evidence of benign mixed tumor is present, the lesion is known as carcinosarcoma “de novo.” We reported the first case of true malignant mixed tumor of the submandibular gland composed of high grade mucoepidermoid carcinoma associated with osteosarcoma.Case Presentation. A 69-year-old Caucasian male came to our department complaining of the appearance of an asymptomatic left submandibular neoformation progressively increasing in size over 3 months. We opted for surgical treatment. Histological examination confirmed the diagnosis of carcinosarcoma with the coexistence of high grade mucoepidermoid carcinoma and osteosarcoma.Conclusion. To the best of our knowledge, in the true malignant mixed tumor of the submandibular gland, mucoepidermoid carcinoma associated with osteosarcoma has never been previously reported.

scholarly journals Lymphoepthelial cyst of submandibular region: a case report

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Sana Iqbal ◽  
Sufyan Ahmed ◽  
Mehwash Kashif
Keyword(s):  
Submandibular Gland ◽  
Tertiary Care ◽  
Clinical Problem ◽  
Care Hospital ◽  
Lymphoepithelial Cyst ◽  
Submandibular Region ◽  
Case Presentation ◽  
Lymphoepithelial Cysts ◽  
Branchial Cleft ◽  
The Right

Abstract Background The oral lymphoepithelial cyst (LEC) is a rare, soft-tissue, developmental cyst, initially presented by Gold in 1962 as a “branchial cleft cyst”. It may occur in the pancreas, tongue, neck, and other regions of the oral cavity. No study has been reported in Pakistan and Karachi reporting a case of lymphoepithelial cyst in the submandibular region. This rare case of LEC has been reported to help the clinicians to bring LEC into their differential diagnosis for lesions affecting the submandibular region. Case presentation We report a case of 57 years old female reported to the Maxillofacial OPD of a tertiary care hospital with the complaint of swelling on the right side of the neck for 3 weeks which was rapidly increasing in size. She was having difficulty in mastication. On extra-oral examination, there was swelling on the right side in the submandibular area. The overlying skin is normal with no evidence of pus and discharge. On palpation, the swelling was soft, non-tender, non-fluctuant, non-displaceable into the submandibular area. Lymph nodes were impalpable. Excision of the lesion performed under general anesthesia and biopsy revealed lymphoepithelial cyst associated with submandibular gland. Here we present an attention-grabbing case of swelling in the right submandibular region which was provisionally diagnosed as a malignant submandibular lymph node however later evidence histopathologically as a lymphoepithelial cyst of the submandibular gland. Conclusion An unusual cause of swelling in the neck is lymphoepithelial cysts. Submandibular gland appearance is not usual and can prove to be a clinical problem.

scholarly journals Carcinoma Expleomorphic Adenoma of the Submandibular Gland

2013 ◽  
Vol 47 (3) ◽  
pp. 162-166
Author(s):  
Akshay Kudpaje ◽  
Sumit Gupta ◽  
Sudhir Naik ◽  
Rajshekar Halkud ◽  
Siddharth Biswas ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Mucoepidermoid Carcinoma ◽  
Needle Aspiration ◽  
High Grade ◽  
Fine Needle ◽  
Efficient Management ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct ◽  
History Of

ABSTRACT Background and objectives Carcinoma expleomorphic adenoma (CXPA) is a rare neoplasm of the salivary gland which arises in the epithelial component of a pleomorphic adenoma. It is not automatically a high-grade tumor as is traditionally suggested and should be further qualified as to type, grade of carcinoma and extent, since intracapsular and minimally invasive tumors behave favorably. Setting Department of Head and Neck oncosurgery, Kidwai Memorial Institute of Oncology, Bengaluru. Case Report A 38-year-old female was referred to our outpatient clinic with history of a painless swelling in the left side of the neck since 8 years. Fine needle aspiration revealed carcinoma of the submandibular gland. Contrast enhanced CT revealed a large heterogeneously enhancing mass lesion in the submandibular fossa with the gland not seen separately. Lymph nodes in level Ib and II were enlarged. Excision of the tumor revealed CXPA with foci of high grade mucoepidermoid carcinoma. Conclusion CXPA should no longer be considered a specific diagnosis but a category in which the carcinoma should be typed, graded and quantitated to impart more prognostically and therapeutically relevant data for efficient management. How to cite this article Naik SM, Shenoy AM, Chavan P, Halkud R, Biswas S, Kalloli M, Gupta S, kudpaje A. Carcinoma Expleomorphic Adenoma of the Submandibular Gland. J Postgrad Med Edu Res 2013;47(3):162-166.

Secretory Carcinoma Ex Pleomorphic Adenoma: A Case Report

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S74-S75
Author(s):  
Erika Egal ◽  
Reydson Souza ◽  
João Scarini ◽  
Antonio Martins ◽  
Andre Casarini ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Pleomorphic Adenoma ◽  
Histopathological Examination ◽  
Morphological Characteristics ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Dystrophic Calcification ◽  
Parotid Glands ◽  
Secretory Carcinoma ◽  
Submandibular Region ◽  
First Case

Abstract The objective of this study is to report a case of carcinoma ex pleomorphic adenoma subclassified as secretory carcinoma ex pleomorphic adenoma frankly invasive. A 60-year-old male patient attended our service for cervical injury assessment, painless with slow and progressive growth for about 3 years. At the clinical examination, an increase in volume in the submandibular region and a lesion in the region of the nasolabial sulcus were observed. A biopsy of the lesion was performed and the morphological characteristics were compatible with secretory carcinoma of the salivary gland. The patient underwent a radical cervical emptying, excision of the left submandibular gland, and removal of the lesion in the left nasogastric sulcus. At the macroscopic examination, the submandibular gland presented a hardened, heterogeneous nodule, poorly delimited, with gross calcification at the center, measuring 2.0 × 1.5 × 1.5 cm. At the histopathological examination, eosinophilic cells containing intracytoplasmic vacuoles, with a ductal formation and solid arrangement and dystrophic calcification, were observed corresponding to the old hyalinized areas of residual PA. In view of these findings, the diagnosis was secretory carcinoma ex adenoma pleomorphic frankly invasive of the submandibular gland with extension to the nasogenian sulcus. Complementary immunohistochemical examination was carried out evidencing positivity for mammaglobin, S100, and CK7 in tumor cells and negativity for calponin, 1A4, and p63. Conclusion: Although CXPA is a rare lesion and is more common in parotid glands, it may affect other locations. Several histopathological phenotypes may arise from the malignant transformation of the PA, but to the best of our understanding, this is the first case of secretory carcinoma ex pleomorphic adenoma reported in the literature.

scholarly journals A CASE OF METASTATIC RENAL TUMOR ORIGINATING FROM A MALIGNANT MIXED TUMOR OF THE SUBMANDIBULAR GLAND

1991 ◽  
Vol 82 (11) ◽  
pp. 1829-1832
Author(s):  
Yukitsugu Kawabata ◽  
Shunji Shimizu ◽  
Kazuo Ieda ◽  
Hiroshi Nakamura ◽  
Shintarou Terahata ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Renal Tumor ◽  
Mixed Tumor ◽  
Malignant Mixed Tumor

Coexisting Benign Mixed Tumor and Mucoepidermoid Carcinoma of the Parotid Gland

1979 ◽  
Vol 88 (3) ◽  
pp. 327-330 ◽  
Author(s):  
Nicholas Pontilena ◽  
Robin M. Rankow
Keyword(s):  
Parotid Gland ◽  
Mucoepidermoid Carcinoma ◽  
Review Of The Literature ◽  
Mixed Tumor ◽  
Parotid Gland Tumors ◽  
Parotid Tumors ◽  
Benign Mixed Tumor ◽  
The Right

Multiple unilateral parotid gland tumors are very rare. A review of the literature shows only seven cases of coexisting unilateral parotid tumors. This patient had a benign mixed tumor and a mucoepidermoid carcinoma of the right parotid gland. This is the eighth reported case of multiple unilateral parotid tumors and the first to show such a combination of tumors.

scholarly journals A New Case of de novo Variant c.892C>T (p.Arg298Trp) in NACC1: A First Case Report From China

2021 ◽  
Vol 9 ◽  
Author(s):  
Baiyu Lyu ◽  
Yan Dong ◽  
Juan Kang
Keyword(s):  
Intellectual Disability ◽  
Congenital Cataract ◽  
De Novo ◽  
Neurodevelopmental Disorder ◽  
Brain Mri ◽  
Case Presentation ◽  
Feeding Difficulties ◽  
Severe Intellectual Disability ◽  
First Case ◽  
Infantile Epilepsy

Background: The nucleus accumbens associated 1 (NACC1) gene is a transcription factor member of the BTB/POZ family. A de novo heterozygous c.892C>T (p.Arg298Trp) variant in the NACC1 may define a syndrome characterized by intellectual disability, infantile epilepsy, congenital cataract, and feeding difficulties.Case Presentation: We report a new case with a neurodevelopmental disorder characterized by severe intellectual disability, infantile epilepsy, congenital cataract, and feeding difficulties. Brain MRI reveals brain dysplasia. We observe a de novo heterozygous c.892C>T (p.Arg298Trp) variant in the NACC1 gene in this case. Now, the child regularly goes to the hospital for rehabilitation training (once a month). Sodium Valproate (10 mg/kg/day) and Clobazam (10 mg/kg/day) are used in the treatment of epilepsy. A total of three articles were screened, and two papers were excluded. The search revealed one article related to a syndrome caused by a de novo heterozygous c.892C>T (p.Arg298Trp) variant in the NACC1; they screened the main clinical features of eight cases of a syndrome, which were summarized and analyzed.Conclusions: The NACC1 gene is a member of the BTB/POZ family of transcription factors. A de novo heterozygous c.892C>T (p.Arg298Trp) variant in the NACC1 may define a syndrome characterized by intellectual disability, infantile epilepsy, congenital cataract, and feeding difficulties. At present, there is no effective cure. In the future, we need more cases to determine the phenotype–genotype correlation of NACC1 variants. Many questions remain to be answered, and many challenges remain to be faced. Future transcriptional studies may further clarify this rare, recurrent variant, and could potentially lead to targeted therapies.

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