scholarly journals Oral Intravascular Papillary Endothelial Hyperplasia Associated with an Organizing Thrombus: Case Report and Immunohistochemical Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Darcy Fernandes ◽  
Daphine Caxias Travassos ◽  
Túlio Morandin Ferrisse ◽  
Elaine Maria Sgavioli Massucato ◽  
Cláudia Maria Navarro ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Benign Lesion ◽  
Microscopic Analysis ◽  
Immunohistochemical Analysis ◽  
Final Diagnosis ◽  
Proliferation Index ◽  
Surgical Removal ◽  
Intravascular Papillary Endothelial Hyperplasia ◽  
Ki 67 ◽  
Papillary Endothelial Hyperplasia

Intravascular papillary endothelial hyperplasia (IPEH) is a benign lesion of the skin and mucosa of vascular origin characterized by reactive proliferation of endothelial cells. A 76-year-old woman was referred presenting a painless nodule on the lip. Intraoral examination revealed bluish submucosal nodular proliferation, measuring 10 × 5 × 5 mm, affecting the lower labial mucosa. The lesion had a firm consistency and it was not fixed to the adjacent tissues. The main differential diagnoses were mucocele/mucus retention cyst, sialolith, or salivary gland neoplasia. An incisional biopsy was performed and during the intraoperative procedure an encapsulated red-bluish nodular mass was observed. Microscopic analysis revealed papillary endothelial proliferation in the center of the lesion and fibrin admixed with inflammatory cells in organization peripherally. There was no nuclear atypia, mitotic figures, or necrosis. The endothelial cells were CD34 positive, with low Ki-67 proliferation index (4%). α-SMA highlighted the vessel walls, whereas negativity for D2-40 excluded lymphatic origin. Final diagnosis was IPEH associated with an organizing thrombus. Dentists should be aware about this rare benign vascular lesion, whose final diagnosis is achieved only after histopathology analysis. Surgical removal is the treatment of choice and no recurrence is expected.

scholarly journals Mandibular odontogenic sarcoma (ameloblastic fibrodentinosarcoma) in an aged cat — Short communication

2017 ◽  
Vol 65 (1) ◽  
pp. 89-95
Author(s):  
Gustavo A. Ramírez ◽  
Lorenzo Ressel ◽  
Jaume Altimira ◽  
Miquel Vilafranca
Keyword(s):  
Alveolar Bone ◽  
S100 Protein ◽  
Final Diagnosis ◽  
Proliferation Index ◽  
Cell Component ◽  
Ki 67 ◽  
Histologic Subtype ◽  
Odontogenic Tumours ◽  
Odontogenic Epithelium ◽  
Shaped Cell

A 13-year-old male cat presented with an ill-defined mass in the rostral mandible causing destruction and loss of alveolar bone. Microscopically, the mass consisted of cords or islands of benign odontogenic epithelium and a malignant, pleomorphic spindle-shaped cell component with dysplastic dentine formation. Immunohistochemically, neoplastic mesenchymal cells proved to be strongly positive for vimentin and negative for cytokeratins, desmin, actin and S100 protein; the Ki67 proliferation index was high. Morphological and immunohistochemical features largely overlap those reported for ameloblastic fibrodentinosarcoma, an uncommon histologic subtype of odontogenic sarcoma recognised in humans but no reported previously in animals. Ki-67 expression assessment may help to discriminate between malignant and benign forms of odontogenic tumours but the final diagnosis is mainly morphological.

CLINICAL, HISTOCHEMICAL, AND IMMUNOHISTOCHEMICAL ANALYSIS OF ORAL INTRAVASCULAR PAPILLARY ENDOTHELIAL HYPERPLASIA

2020 ◽  
Vol 129 (1) ◽  
pp. e52
Author(s):  
ÁLVARO CAVALHEIRO SOARES ◽  
RUTH TRAMONTANI RAMOS ◽  
GERALDO OLIVEIRA SILVA ◽  
MARILIA HEFFER CANTISANO ◽  
FÁBIO RAMÔA PIRES
Keyword(s):  
Immunohistochemical Analysis ◽  
Intravascular Papillary Endothelial Hyperplasia ◽  
Papillary Endothelial Hyperplasia

scholarly journals Masson’s Tumor of the Hand: An Uncommon Histopathological Entity

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Parviz Mardani ◽  
Amir Askari ◽  
Reza Shahriarirad ◽  
Keivan Ranjbar ◽  
Amirhossein Erfani ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Vascular Lesion ◽  
Accurate Diagnosis ◽  
Intravascular Papillary Endothelial Hyperplasia ◽  
Masson’S Tumor ◽  
Papillary Endothelial Hyperplasia ◽  
Subcutaneous Tissues ◽  
Malignant Lesions ◽  
Masson’S Hemangioma

Masson’s tumor or Masson’s hemangioma, more precisely termed intravascular papillary endothelial hyperplasia (IPEH), is an uncommon benign vascular lesion of the skin and subcutaneous tissues which can be frequently confused with angiosarcoma. Although relatively rare, its accurate diagnosis is essential since it can clinically be similar to both benign and malignant lesions. We present a 39-year-old man with a round bulging arising from the left palm side of the hand with gradual growth in the last 5 months and on and off tenderness. The microscopic section demonstrated the papillary proliferation of endothelial cells in favor of Masson’s hemangioma, which was sufficiently treated with excision alone.

scholarly journals Intravascular Papillary Endothelial Hyperplasia Associated with Venous Pool Arising in the Lower Lip: A Case Report

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Hisanobu Yonezawa ◽  
Akimitsu Hiraki ◽  
Ken-ichi Iyama ◽  
Masanori Shinohara
Keyword(s):  
Endothelial Cells ◽  
Vascular Tissue ◽  
Clinical Course ◽  
Histopathological Examination ◽  
Vascular Lesion ◽  
Intravascular Papillary Endothelial Hyperplasia ◽  
Lower Lip ◽  
Radiologic Findings ◽  
Papillary Endothelial Hyperplasia ◽  
Benign Nature

Intravascular papillary endothelial hyperplasia is a benign nonneoplastic vascular lesion that consists of endothelial cells with abundant vascular tissue with papillary proliferation. An adult female had a painless growing dark red nodule on the left side of the lower lip and often touched and gnawed at it for more than 4 years. The lesion was a tender, smooth mass approximately 1 cm in diameter without discoloration reaction. Magnetic resonance imaging of the lesion showed specific findings. She was diagnosed clinically as having mimicked hemangioma, and the lesion was totally excised under local anesthesia. Histopathological examination revealed that papillary proliferated endothelial cells with venous pool, and the lesion was diagnosed as intravascular papillary endothelial hyperplasia associated with venous pool. There has been no recurrence for more than 1 year. Despite the benign nature of this lesion, it could have been mistaken for a malignant tumor because of its clinical course and radiologic findings.

scholarly journals A Case of Masson’s Tumor in Lateral Neck

2020 ◽  
Vol 63 (11) ◽  
pp. 541-544
Author(s):  
Hoyoung Lee ◽  
Soo Jeong Choi ◽  
In Hak Choi ◽  
Kwang Yoon Jung
Keyword(s):  
Endothelial Cells ◽  
Differential Diagnosis ◽  
Rare Case ◽  
Vascular Tumor ◽  
Neck Mass ◽  
Lateral Neck ◽  
Intravascular Papillary Endothelial Hyperplasia ◽  
Masson’S Tumor ◽  
Papillary Endothelial Hyperplasia ◽  
The Right

Masson’s tumor, also known as intravascular papillary endothelial hyperplasia (IPEH), is a rare, benign vascular tumor characterized by the proliferation of endothelial cells with papillary formations. Differential diagnosis between IPEH and angiosarcoma is important because both have microscopic similarity. Herein, we report a rare case of IPEH on the right lateral neck of a 50-year-old female presenting with a neck mass, which was completely removed without complication.

scholarly journals Glomus tumor of small intestine: case report and review of literature

2021 ◽  
Author(s):  
Yan Tan ◽  
Xinyi Wang ◽  
Guifang Yang ◽  
Lan Liu ◽  
Jun Fang ◽  
...  
Keyword(s):  
Small Intestine ◽  
Glomus Tumor ◽  
Final Diagnosis ◽  
Good Prognosis ◽  
Proliferation Index ◽  
Review Of Literature ◽  
Ki 67 ◽  
Glomus Tumors ◽  
Single Balloon ◽  
Single Balloon Enteroscopy

Abstract BackgroundGlomus tumors are exceedingly rare tumors arising from the normal glomus body. Only a very few cases of glomus tumors located in the small intestine were reported to date. Here, we present a case of glomus tumor of the jejunum in a 30-year-old female patient, and discuss its clinical, imaging, and pathologic features.Case presentationA 30-year-old female referred to our hospital with the chief complain of melena and fatigue for 3 weeks. Oral single-balloon enteroscopy discovered a 2.0*2.0cm tumor without epithelial lining in the jejunum. The patient then underwent partial enterectomy. HE stain illustrated that the tumor was interspersed with congestive capillaries of various size, and admixed with smooth muscle bundles. Immunohistochemical study showed that the tumor cells were strongly positive for SMA and collagen type Ⅳ. The Ki-67 proliferation index was less than 1% and mitotic activity is very low (about 1/50 HPF). The case was finally diagnosed as benign glomus tumor.ConclusionsGlomus tumors arising from the small intestine are extremely rare. The final diagnosis is made by histological and immunohistochemical examination. Although there is no standardized management pathway for these patients, early diagnosis and treatment are important for a good prognosis.

scholarly journals Neurendocrine tumor of common hepatic duct: an uncommon site tumor

2019 ◽  
Vol 9 (2) ◽  
pp. 1599-1603
Author(s):  
Pallavi Srivastava ◽  
Saumya Shukla ◽  
Nuzhat Husain ◽  
Priyanka Sameer
Keyword(s):  
Neuroendocrine Tumor ◽  
Epigastric Pain ◽  
Hepatic Duct ◽  
Tumor Resection ◽  
Final Diagnosis ◽  
Proliferation Index ◽  
Common Hepatic Duct ◽  
Intravenous Chemotherapy ◽  
Ki 67 ◽  
Histopathology Examination

The neuroendocrine tumor of extrahepatic biliary tract is a rare neoplasm of the gastrointestinal tract. We present a case of 16 year old male presenting with epigastric pain and jaundice with a well-defined lesion in common hepatic duct on imaging. The patient underwent tumor resection. Histopathology examination revealed thickened common hepatic duct infiltrated by tumor cells with expression of Pan CK, Synaptophysin & Chromogranin with Ki- 67 proliferation index of 5%. The final diagnosis of Neuroendocrine tumor of Common Hepatic Duct, grade 2 was rendered. The patient showed no recurrence to date without intravenous chemotherapy.

scholarly journals Glomus Tumor of Small Intestine: Case Report and Review of Literature

2021 ◽  
Author(s):  
Yan Tan ◽  
Xinyi Wang ◽  
Guifang Yang ◽  
Lan Liu ◽  
Jun Fang ◽  
...  
Keyword(s):  
Small Intestine ◽  
Glomus Tumor ◽  
Final Diagnosis ◽  
Good Prognosis ◽  
Proliferation Index ◽  
Ki 67 ◽  
Glomus Tumors ◽  
Pathologic Features ◽  
Single Balloon ◽  
Single Balloon Enteroscopy

Abstract Background: Glomus tumors are exceedingly rare tumors arising from the normal glomus body. Only a very few cases of glomus tumors located in the small intestine were reported to date. Here, we present a case of glomus tumor of the jejunum in a 30-year-old female patient, and discuss its clinical, imaging, and pathologic features.Case presentation: A 30-year-old female referred to our hospital with the chief complain of melena and fatigue for 3 weeks. Oral single-balloon enteroscopy discovered a 2.0*2.0cm tumor without epithelial lining in the jejunum. The patient then underwent partial enterectomy. HE stain illustrated that the tumor was interspersed with congestive capillaries of various size, and admixed with smooth muscle bundles. Immunohistochemical study showed that the tumor cells were strongly positive for SMA and collagen type Ⅳ. The Ki-67 proliferation index was less than 1% and mitotic activity is very low (about 1/50 HPF). The case was finally diagnosed as benign glomus tumor. Conclusion: Glomus tumors arising from the small intestine are extremely rare. The final diagnosis is made by histological and immunohistochemical examination. Although there is no standardized management pathway for these patients, early diagnosis and treatment are important for a good prognosis.

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