scholarly journals Cytokine Profile in Chronic Periodontitis Patients with and without Obesity: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Zohaib Akram ◽  
Tariq Abduljabbar ◽  
Mohamed Ibrahim Abu Hassan ◽  
Fawad Javed ◽  
Fahim Vohra
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Meta Analysis ◽  
Cytokine Profile ◽  
Obese Patients ◽  
Necrosis Factor Alpha ◽  
Periodontal Inflammation ◽  
Mesh Terms ◽  
Meta Analyses ◽  
Crevicular Fluid

To investigate the cytokine profile as biomarkers in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with and without obesity, MEDLINE/PubMed, EMBASE, ScienceDirect, and SCOPUS databases were combined with handsearching of articles published from 1977 up to May 2016 using relevant MeSH terms. Meta-analyses were conducted separately for each of the cytokines: resistin, adiponectin, TNF-α, leptin, IL-6, IL-8, and IL-1β. Forest plots were produced reporting standardized mean difference of outcomes and 95% confidence intervals. Eleven studies were included. Three studies showed comparable levels of leptin among obese and nonobese patients with CP. Four studies reported comparable levels of interleukin- (IL-) 6 and resistin whereas five studies reported comparable levels of adiponectin. Two studies reported similar levels of CRP in patients with periodontitis with and without obesity. One study showed higher levels of tumor necrosis factor-alpha in obese patients with CP. One study showed higher levels of IL-1βand IL-8 in obese patients with CP. The level of localized periodontal inflammation may have a greater influence on the GCF proinflammatory biomarker levels as compared to systemic obesity. Whether patients having chronic periodontitis with obesity have elevated proinflammatory GCF biomarkers levels compared to nonobese individuals remains debatable.

scholarly journals Periodontal Treatment Downregulates Protease-Activated Receptor 2 in Human Gingival Crevicular Fluid Cells

2013 ◽  
Vol 81 (12) ◽  
pp. 4399-4407 ◽  
Author(s):  
Vanessa Tubero Euzebio Alves ◽  
Henrique Aparecido Bueno da Silva ◽  
Bruno Nunes de França ◽  
Rosangela Santos Eichler ◽  
Luciana Saraiva ◽  
...  
Keyword(s):  
Growth Factor ◽  
Inflammatory Mediators ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Periodontal Treatment ◽  
Positive Staining ◽  
Proinflammatory Mediators ◽  
Periodontal Inflammation ◽  
Crevicular Fluid ◽  
Protease Activated Receptor 2

ABSTRACTProtease-activated receptor 2 (PAR2) is implicated in the pathogenesis of chronic inflammatory diseases, including periodontitis; it can be activated by gingipain and produced byPorphyromonas gingivalisand by neutrophil protease 3 (P3). PAR2 activation plays a relevant role in inflammatory processes by inducing the release of important inflammatory mediators associated with periodontal breakdown. The effects of periodontal treatment on PAR2 expression and its association with levels of proinflammatory mediators and activating proteases were investigated in chronic periodontitis patients. Positive staining for PAR2 was observed in gingival crevicular fluid cells and was reflective of tissue destruction. Overexpression of PAR2 was positively associated with inflammatory clinical parameters and with the levels of interleukin-6 (IL-6), IL-8, tumor necrosis factor alpha, matrix metalloprotease 2 (MMP-2), MMP-8, hepatocyte growth factor, and vascular endothelial growth factor. Elevated levels of gingipain and P3 and decreased levels of dentilisin and the protease inhibitors secretory leukocyte protease inhibitor and elafin were also associated with PAR2 overexpression. Healthy periodontal sites from individuals with chronic periodontitis showed diminished expression of PAR2 mRNA and the PAR2 protein (P< 0.05). Furthermore, periodontal treatment resulted in decreased PAR2 expression and correlated with decreased expression of inflammatory mediators and activating proteases. We concluded that periodontal treatment resulted in decreased levels of proteases and that proinflammatory mediators are associated with decreased PAR2 expression, suggesting that PAR2 expression is influenced by the presence of periodontal infection and is not a constitutive characteristic favoring periodontal inflammation.

Cytokine profile in the gingival crevicular fluid of rheumatoid arthritis patients with chronic periodontitis

2013 ◽  
Vol 5 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Fawad Javed ◽  
Hameeda B. Ahmed ◽  
Toshinari Mikami ◽  
Khalid Almas ◽  
Georgios E. Romanos ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Cytokine Profile ◽  
Crevicular Fluid

Gingival crevicular fluid levels of cytokines/chemokines in chronic periodontitis: a meta-analysis

2016 ◽  
Vol 43 (9) ◽  
pp. 727-745 ◽  
Author(s):  
Amanda F. Stadler ◽  
Patrícia D. M. Angst ◽  
Roger M. Arce ◽  
Sabrina C. Gomes ◽  
Rui V. Oppermann ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Meta Analysis ◽  
Crevicular Fluid ◽  
Fluid Levels

scholarly journals Pre-Procedural Lumbar Neuraxial Ultrasound—A Systematic Review of Randomized Controlled Trials and Meta-Analysis

Healthcare ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 479
Author(s):  
Tatiana Sidiropoulou ◽  
Kalliopi Christodoulaki ◽  
Charalampos Siristatidis
Keyword(s):  
Systematic Review ◽  
Lumbar Spine ◽  
Randomized Controlled Trials ◽  
Success Rate ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Technical Failure ◽  
Obese Patients ◽  
Randomized Controlled ◽  
Meta Analyses

A pre-procedural ultrasound of the lumbar spine is frequently used to facilitate neuraxial procedures. The aim of this review is to examine the evidence sustaining the utilization of pre-procedural neuraxial ultrasound compared to conventional methods. We perform a systematic review of randomized controlled trials with meta-analyses. We search the electronic databases Medline, Cochrane Central, Science Direct and Scopus up to 1 June 2019. We include trials comparing a pre-procedural lumbar spine ultrasound to a non-ultrasound-assisted method. The primary endpoints are technical failure rate, first-attempt success rate, number of needle redirections and procedure time. We retrieve 32 trials (3439 patients) comparing pre-procedural lumbar ultrasounds to palpations for neuraxial procedures in various clinical settings. Pre-procedural ultrasounds decrease the overall risk of technical failure (Risk Ratio (RR) 0.69 (99% CI, 0.43 to 1.10), p = 0.04) but not in obese and difficult spinal patients (RR 0.53, p = 0.06) and increase the first-attempt success rate (RR 1.5 (99% CI, 1.22 to 1.86), p < 0.0001, NNT = 5). In difficult spines and obese patients, the RR is 1.84 (99% CI, 1.44 to 2.3; p < 0.0001, NNT = 3). The number of needle redirections is lower with pre-procedural ultrasounds (SMD = −0.55 (99% CI, −0.81 to −0.29), p < 0.0001), as is the case in difficult spines and obese patients (SMD = −0.85 (99% CI, −1.08 to −0.61), p < 0.0001). No differences are observed in procedural times. Ιn conclusion, a pre-procedural ultrasound provides significant benefit in terms of technical failure, number of needle redirections and first attempt-success rate. Τhe effect of pre-procedural ultrasound scanning of the lumbar spine is more significant in a subgroup analysis of difficult spines and obese patients.

scholarly journals The Effect of Nonsurgical Periodontal Therapy on HNP1-3 Level in Gingival Crevicular Fluid of Chronic Periodontitis Patients

2017 ◽  
Vol 65 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Ewa Dolińska ◽  
Anna Skurska ◽  
Małgorzata Pietruska ◽  
Violetta Dymicka-Piekarska ◽  
Robert Milewski ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Periodontal Therapy ◽  
Nonsurgical Periodontal Therapy ◽  
Crevicular Fluid
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