scholarly journals Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Ehtasham Ahmad ◽  
Mohamed Mohamed ◽  
Apostolos Vrettos
Keyword(s):  
Visual Impairment ◽  
Pathological Features ◽  
Imaging Studies ◽  
Primary Diffuse Leptomeningeal Gliomatosis ◽  
Leptomeningeal Gliomatosis ◽  
Protein Levels ◽  
Csf Analysis ◽  
Diagnostic Biopsy

We present the case of a 43-year-old lady who presented with headaches, visual impairment, and seizures, progressing rapidly over the course of a few weeks. Extensive workup excluded an inflammatory or infectious cause. Imaging studies revealed diffuse thickening of the leptomeninges and serial CSF analysis showed raised opening pressures and increased protein levels. A diagnostic biopsy of the lower thoracic dura confirmed the diagnosis of primary diffuse leptomeningeal gliomatosis (PDGL). She was managed supportively for her symptoms and unfortunately she passed away a few weeks later.

scholarly journals Neonatal Ureaplasma parvum meningitis complicated with subdural hematoma: a case report and literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Canyang Zhan ◽  
Lihua Chen ◽  
Lingling Hu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Subdural Hematoma ◽  
Central Nervous System Infection ◽  
Neonatal Meningitis ◽  
High Morbidity ◽  
Ureaplasma Parvum ◽  
Protein Levels ◽  
Csf Analysis ◽  
Empirical Antibiotics

Abstract Background Neonatal meningitis is a severe infectious disease of the central nervous system with high morbidity and mortality. Ureaplasma parvum is extremely rare in neonatal central nervous system infection. Case presentation We herein report a case of U. parvum meningitis in a full-term neonate who presented with fever and seizure complicated with subdural hematoma. After hematoma evacuation, the seizure disappeared, though the fever remained. Cerebrospinal fluid (CSF) analysis showed inflammation with CSF pleocytosis (1135–1319 leukocytes/μl, mainly lymphocytes), elevated CSF protein levels (1.36–2.259 g/l) and decreased CSF glucose (0.45–1.21 mmol/l). However, no bacterial or viral pathogens in either CSF or blood were detected by routine culture or serology. Additionally, PCR for enteroviruses and herpes simplex virus was negative. Furthermore, the CSF findings did not improve with empirical antibiotics, and the baby experienced repeated fever. Thus, we performed metagenomic next-generation sequencing (mNGS) to identify the etiology of the infection. U. parvum was identified by mNGS in CSF samples and confirmed by culture incubation on mycoplasma identification medium. The patient’s condition improved after treatment with erythromycin for approximately 5 weeks. Conclusions Considering the difficulty of etiological diagnosis in neonatal U. parvum meningitis, mNGS might offer a new strategy for diagnosing neurological infections.

scholarly journals Cerebrospinal fluid examination may be useful in diagnosing neurosyphilis in asymptomatic HIV+ patients with syphilis

2016 ◽  
Vol 74 (2) ◽  
pp. 128-132 ◽  
Author(s):  
Ronald Salamano ◽  
Raquel Ballesté ◽  
Abayubá Perna ◽  
Natalia Rodriguez ◽  
Diego Lombardo ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Venereal Disease ◽  
Treponema Pallidum ◽  
Hiv Patients ◽  
Hemagglutination Assay ◽  
Protein Levels ◽  
Disease Research ◽  
Csf Analysis ◽  
High Degree ◽  
Asymptomatic Hiv

ABSTRACT Lumbar puncture in neurologically asymptomatic HIV+ patients is still under debate. There are different criteria for detecting neurosyphilis through cerebrospinal fluid (CSF), especially in cases that are negative through the Venereal Disease Research Laboratory (VDRL), regarding cellularity and protein content. However, a diagnosis of neurosyphilis can still exist despite negative VDRL. Treponema pallidum hemagglutination assay (TPHA) titers and application of the TPHA index in albumin and IgG improve the sensitivity, with a high degree of specificity. Thirty-two patients were selected for this study. VDRL was positive in five of them. The number of diagnoses reached 14 when the other techniques were added. It was not determined whether cellularity and increased protein levels were auxiliary tools in the diagnosis. According to our investigation, CSF analysis using the abovementioned techniques may be useful in diagnosing neurosyphilis in these patients.

scholarly journals Teaching NeuroImages: FDG-PET imaging in primary diffuse leptomeningeal gliomatosis

Neurology ◽  
2013 ◽  
Vol 81 (16) ◽  
pp. e119-e120
Author(s):  
A. Weijenberg ◽  
J. M. C. van Dijk ◽  
J. Pruim ◽  
G.-J. Luijckx
Keyword(s):  
Pet Imaging ◽  
Fdg Pet ◽  
Primary Diffuse Leptomeningeal Gliomatosis ◽  
Leptomeningeal Gliomatosis

Primary diffuse leptomeningeal gliomatosis with anaplastic features

1995 ◽  
Vol 132 (1-3) ◽  
pp. 154-159 ◽  
Author(s):  
M. T. Giordana ◽  
G. B. Bradac ◽  
C. A. Pagni ◽  
S. Marino ◽  
A. Attanasio
Keyword(s):  
Primary Diffuse Leptomeningeal Gliomatosis ◽  
Leptomeningeal Gliomatosis

High-grade primary diffuse leptomeningeal gliomatosis in a child with neurofibromatosis Type 1

2008 ◽  
Vol 2 (6) ◽  
pp. 402-405 ◽  
Author(s):  
James A. J. King ◽  
William Halliday ◽  
James M. Drake
Keyword(s):  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
High Grade ◽  
First Report ◽  
Primary Diffuse Leptomeningeal Gliomatosis ◽  
Leptomeningeal Gliomatosis ◽  
Primary Glioma

The authors report on a child with known neurofibromatosis Type 1 who developed high-grade diffuse leptomeningeal gliomatosis, without a known primary glioma. To the authors' knowledge, this is the first report of the coexistence of these conditions in a child.

Primary diffuse leptomeningeal gliomatosis: do we miss the diagnosis?

2017 ◽  
Vol 36 (09) ◽  
pp. 222-226 ◽  
Author(s):  
Sébastien Lepreux ◽  
Sharmilla Sagnier ◽  
Jean-Thomas Perez ◽  
François Léger ◽  
Igor Sibon ◽  
...  
Keyword(s):  
Primary Diffuse Leptomeningeal Gliomatosis ◽  
Leptomeningeal Gliomatosis
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