scholarly journals Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM)

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Luiz H. Lima ◽  
Yael Morales ◽  
Thiago Cabral
Keyword(s):  
Inflammatory Reaction ◽  
Intravitreal Injections ◽  
Tissue Adhesive ◽  
Fundus Photography ◽  
Histopathological Study ◽  
Retinal Diseases ◽  
Retinal Damage ◽  
Fundus Fluorescein Angiography ◽  
The Right

Purpose. To study the safety of intravitreal injections of poly-N-isopropylacrylamide (pNIPAM) tissue adhesive in rabbit eyes. Methods. Twelve study rabbits received an intravitreal injection of 0.1 mL 50% pNIPAM in the right eye. Follow-up examinations included color fundus photography, fundus fluorescein angiography (FA), optical coherence tomography (OCT), and electroretinography (ERG). Subsequent to the last follow-up assessment, the rabbits were sacrificed and histopathological study on the scleral incision sites was performed. Results. All study animals developed mild to moderate levels of inflammatory reaction in the conjunctiva, anterior chamber, and the anterior vitreous during the first month of follow-up. After this period, the level of the inflammatory reaction progressively decreased and completely disappeared after the third month of follow-up. The lens and cornea remained clear during the entire follow-up period. OCT and FA did not show areas of retinal damage or neovascularization. Histological and ERG studies of eyes injected with pNIPAM demonstrated absence of retinal toxicity. Conclusion. Intravitreal injections of pNIPAM were nontoxic in this animal study, and pNIPAM may be safe to be used as a bioadhesive in certain retinal diseases.

scholarly journals Urrets-Zavalia Syndrome Following Cataract Surgery

2021 ◽  
pp. 659-663
Author(s):  
Shimon Kurtz ◽  
Maayan Fradkin
Keyword(s):  
Intraocular Pressure ◽  
Case Report ◽  
Cataract Surgery ◽  
Anterior Chamber ◽  
Inflammatory Reaction ◽  
Intraocular Lens Implantation ◽  
Postoperative Course ◽  
Lens Implantation ◽  
The Right

We describe a case of Urrets-Zavalia syndrome (UZS) in a healthy 56-year-old woman who underwent femtosecond-assisted phacoemulsification with intraocular lens implantation in both eyes. One month after an uneventful postoperative course in the left eye, the right eye was operated. Dilated pupil which was nonreactive to light appeared on day 21 postoperatively. This was discovered upon examination following anterior chamber inflammatory reaction which occurred 2 weeks following her surgery. Our case report emphasizes the importance and danger in developing UZS even if the reaction in the anterior chamber does not occur immediately after surgery. In addition, the importance of intraocular pressure follow-up in the period after UZS is acknowledged.

Optical Coherence Tomography Angiography in idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) syndrome: A case report

2020 ◽  
pp. 112067212095759
Author(s):  
Meriem Ouederni ◽  
Hela Sassi ◽  
Zied Chelly ◽  
Fehmy Nefaa ◽  
Monia Cheour
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Vasculitis ◽  
Retinal Neovascularization ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography ◽  
Blurred Vision ◽  
Additional Tool ◽  
The Right

Purpose: Since its first description by Chang et al. in 1995, the diagnosis of Idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) syndrome has been based on the findings of Fundus Fluorescein Angiography (FFA). Our purpose was to describe the utility of optical coherence tomography angiography (OCT-A) in its diagnosis and management. Case description: A 40-year-old female presented with bilateral blurred vision. Her best corrected visual acuity was at 8/10. Fundus examination revealed blurred disc margins, perivascular exudates, arterial sheaths and retinal hemorrhages bilaterally. FFA showed staining of the optic disc with dye leakage in the right eye, a punctuate hyperfluorescence of the temporosuperior artery in the left eye, bilateral vascular sheathing and capillary dropout. OCT-A showed simultaneous presence of papillary aneurysm and neovascularization of the optic nerve head in the right eye, a papillary aneurysm in the left eye and bilateral capillary non-perfusion. Our patient was diagnosed with IRVAN syndrome. Oral steroids associated with panretinal laser photocoagulation and intravitreal injection of bevacizumab in the right eye resulted in vanishing of the papillary neovascularization with no recurrence on OCT-A at 10-month follow-up. Conclusions: OCT-A is an additional tool to FFA for visualization of arterial macroaneurysms and retinal neovascularization without the interference of dye leakage. It well demarcates nonperfused areas and ensures follow-up of retinal neovascularization. Its limitations are the limited field of view and the low sensitivity in detecting arteriolar dilations. Thus, OCT-A is unable to outplace FFA but should be considered alternately with it for non-invasive follow-up of IRVAN syndrome.

scholarly journals Adult Coats Disease Presenting as Subfoveal Nodule

2018 ◽  
Vol 9 (1) ◽  
pp. 232-237 ◽  
Author(s):  
Salim Z. Asaad ◽  
Nazimul Hussain
Keyword(s):  
Retinal Vessel ◽  
Fundus Fluorescein Angiography ◽  
The Third ◽  
Macular Lesion ◽  
Corrected Visual Acuity ◽  
Coats Disease ◽  
The Right ◽  
Lost To Follow Up ◽  
Best Corrected Visual Acuity

A 21-year-old female presented with decreased vision in the right eye. Best corrected visual acuity was 6/60 in the right eye and 6/6 in the left eye. Funduscopy of the right eye revealed a subfoveal nodule with surrounding exudates and temporal peripheral retinal vessel telangiectasia with exudation. The patient underwent retinal laser in the areas of telangiectatic vessels and capillary non-perfusion as seen on fundus fluorescein angiography. It was combined with an intravitreal injection of bevacizumab which was repeated twice at monthly intervals. The macular lesion and peripheral vessels along with subretinal exudates showed resolution during the course of treatment. However, the patient was lost to follow-up and returned 5 months later when examination revealed increased macular fibrosis. In the literature, the reported presentation of subfoveal nodule in Coats disease is during the first decade. It progresses to macular fibrosis within a few months. This case illustrates that subfoveal nodule before macular fibrosis in Coats disease may present later, even up to the third decade.

scholarly journals Primary Ewing sarcoma of squamous temporal bone with intracranial extension: a case report

2016 ◽  
Vol 30 (2) ◽  
pp. 296-299 ◽  
Author(s):  
Somil Jaiswal ◽  
Pooja Jaiswal ◽  
Bal Krishna Ojha ◽  
Anil Chandra
Keyword(s):  
Temporal Bone ◽  
Ewing Sarcoma ◽  
Intracranial Extension ◽  
Histopathological Study ◽  
Eastern India ◽  
Imaging Studies ◽  
Sporadic Cases ◽  
The Right ◽  
Radio Chemotherapy

Abstract Primary Cranial Ewing sarcoma (ES) is rare and that of temporal bone is even rarer entity. Only a few sporadic cases have been reported and no such case has been reported from Eastern India In this report we describe a case of 18 yrs old male with primary cranial ES of squamous temporal bone involving intracranial and extracranial compartment. The patient presented with swelling in zygomatic fossa and imaging studies showed a mass originating in the right temporal bone. Gross total resection of the tumor was done and sent for histopathological study. The case was referred for radio-chemotherapy and had no recurrence up to eight months of follow up.

scholarly journals Acute Macular Neuroretinopathy in a Patient with Retinal Vascular Tortuosity

2021 ◽  
pp. 412-417
Author(s):  
Izabella Karska-Basta ◽  
Weronika Pociej-Marciak ◽  
Bożena Romanowska-Dixon ◽  
Barbara Bukowska-Mikos
Keyword(s):  
Rare Case ◽  
Imaging Techniques ◽  
Fundus Photography ◽  
Common Finding ◽  
Retinal Vessels ◽  
Vascular Tortuosity ◽  
Acute Macular Neuroretinopathy ◽  
The Right ◽  
Retinal Vascular Tortuosity

We report a rare case of a young woman with acute macular neuroretinopathy (AMN) in the right eye and concomitant retinal vascular tortuosity in both eyes. A 19-years-old woman presented with a sudden loss of central vision in the right eye. Apart from flu-like infection 2 weeks before the onset of symptoms, she reported overall good health. She used oral contraceptive pills. Multimodal imaging techniques including color fundus photography, fundus autofluorescence, infrared reflectance imaging, fluorescein angiography, swept-source optical coherence tomography (SS-OCT), and visual field assessment were used for the diagnosis of AMN as well as disease monitoring during follow-up. At presentation, ophthalmoscopy revealed a reddish parafoveal lesion, while SS-OCT showed hyper-reflectivity in the outer plexiform and outer nuclear layers with a slightly disrupted inner segment/outer segment junction. All these imaging findings indicated AMN, but the interpretation was slightly difficult due to the presence of tortuous retinal arteries in both eyes. During the disease course, functional and morphological recovery was documented at 1- and 6-month follow-up. However, as the abnormal appearance of the retinal vessels did not change, congenital retinal vascular tortuosity was diagnosed. Since the pathogenesis of AMN has not been fully elucidated, there is currently no effective treatment. Numerous studies have emphasized a vascular origin and the key role of ischemia in AMN. Our rare case suggests that congenital tortuosity of the retinal vessels, although constituting a common finding in healthy individuals, may be involved in the pathophysiology of the disease.

scholarly journals Multimodal Imaging in a Case with Bilateral Choroidal Folds

2021 ◽  
pp. 585-593
Author(s):  
David Xu ◽  
Ambar Faridi
Keyword(s):  
Multimodal Imaging ◽  
Fundus Autofluorescence ◽  
Fundus Photography ◽  
Pattern Dystrophy ◽  
Snellen Visual Acuity ◽  
Bevacizumab Treatment ◽  
Treatment Naïve ◽  
Choroidal Folds ◽  
The Right

We highlight the use of multimodal imaging to diagnose and report what is, to our knowledge, a novel presentation of bilateral choroidal neovascularization (CNV) and prominent macular choroidal folds (CFs) in a patient with pattern dystrophy. An 81-year-old Caucasian male presented with painless, blurry central vision in both eyes. Color fundus photography, spectral-domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), fundus autofluorescence, and brightness scan ultrasonography supported the diagnosis of pattern dystrophy with bilateral CNV and CF. In the right eye, visually significant CNV worsened post-bevacizumab treatment but responded well to aflibercept. During 4-year follow-up, Snellen visual acuity remained excellent in both eyes at 20/20, including the treatment-naïve left eye. CFs remained markedly stable in both eyes.

scholarly journals A Case of Chorioretinitis with Retinal Angiomatous Proliferation

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yanru Chen ◽  
Mingyan Wei ◽  
Qian Chen ◽  
Minghan Li
Keyword(s):  
Inflammatory Cells ◽  
Interleukin 10 ◽  
Retinal Angiomatous Proliferation ◽  
Fundus Photography ◽  
Endogenous Endophthalmitis ◽  
Fundus Fluorescein Angiography ◽  
Blurred Vision ◽  
Corrected Visual Acuity ◽  
The Right ◽  
Systemic Condition

A 48-year-old woman had an acute blurred vision in the right eye immediately after drainage of liver abscess. Her best corrected visual acuity (BCVA) was 8/400; fundus photography suggested the diagnosis of endogenous endophthalmitis with chorioretinitis and vitritis. Due to the bad systemic condition, a systemic antibiotic combined with periocular triamcinolone (TA) was carried out first. Inflammatory cells in the vitreous cavity were decreased after treatment; however, fundus fluorescein angiography (FFA) showed abnormal dilation and leakage of the capillaries and retinal-choroidal anastomose, supporting that there was retinal angiomatous proliferation (RAP). Vitreous interleukin-6 (IL-6) was only slightly elevated; the ratio of interleukin-10 (IL-10) and IL-6 was less than 1, and the etiological test was negative. After receiving intravitreal vancomycin injection combined with periocular TA injection, the patient’s BCVA was improved from 16/400 to 20/400 with a reduction in vitreous inflammatory cells. However, the patient’s RAP was progressed and her BCVA was dramatically decreased to count finger/30 cm. After intravitreal injection of ranibizumab, the patient’s BCVA was 5/400 with a significant shrink in lesions and absorption of hemorrhage, exudation, and fluid. Thus, we suggest that early anti-inflammatory treatment in conjunction with anti-VEGF may achieve a better prognosis in patients with inflammatory retinal angiomatous proliferation (RAP).

scholarly journals Case Report: Self-Resolved Macular Edema Secondary to Congenital Retinal Macrovessels

2022 ◽  
Vol 8 ◽  
Author(s):  
Fang Zheng ◽  
Kairan Lai ◽  
Houfa Yin ◽  
Jingliang He ◽  
Yufeng Xu ◽  
...  
Keyword(s):  
Macular Edema ◽  
Plexiform Layer ◽  
Fundus Examination ◽  
Pressure Treatment ◽  
Fundus Fluorescein Angiography ◽  
Good Visual Acuity ◽  
Retinal Capillary ◽  
Blurry Vision ◽  
The Right

PurposeTo report a case of macular edema secondary to congenital retinal macrovessels (CRMs), which resolved spontaneously without any treatment.ObservationsA 39-year-old female presented with blurry vision of the right eye for one day. Fundus examination revealed a branch of artery and vein of the inferior retinal arcade crossing the horizontal raphe. Optical coherence tomography (OCT) through the fovea showed cystoid macular edema in the outer plexiform layer. However, no leakage of the vessels was noticed by fundus fluorescein angiography (FFA). Observation was recommended with close follow-up. Two weeks later, the patient returned with good visual acuity, and the macular edema was resolved spontaneously.ConclusionsMacular edema is a possible complication of CRM by increasing retinal capillary hydrostatic pressure. Treatment is not necessary for this kind of macular edema if no leakage of the vessels is noticed on FFA.

CASE REPORT: SURGICAL MANAGEMENT OF LUMBAR COMPRESSION FRACTURE

2019 ◽  
Vol 1 (4) ◽  
Author(s):  
Yustinus Robby Budiman Gondowardojo ◽  
Tjokorda Gde Bagus Mahadewa
Keyword(s):  
Spinal Cord ◽  
Left Lung ◽  
Lumbar Vertebrae ◽  
Compression Fracture ◽  
High Mobility ◽  
Early Mobilization ◽  
Cord Injury ◽  
Cardiothoracic Surgeon ◽  
The Right

The lumbar vertebrae are the most common site for fracture incident because of its high mobility. The spinal cord injury usually happened as a result of a direct traumatic blow to the spine causing fractured and compressed spinal cord. A 38-year-old man presented with lumbar spine’s compression fracture at L2 level. In this patient, decompression laminectomy, stabilization, and fusion were done by posterior approach. The operation was successful, according to the X-Ray and patient’s early mobilization. Pneumothorax of the right lung and pleural effusion of the left lung occurred in this patient, so consultation was made to a cardiothoracic surgeon. Chest tube and WSD insertion were performed to treat the comorbidities. Although the patient had multiple trauma that threat a patient’s life, the management was done quickly, so the problems could be solved thus saving the patient’s life. After two months follow up, the patient could already walk and do daily activities independently.

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