scholarly journals Recurrent Thyrotoxicosis due to Both Graves’ Disease and Hashimoto’s Thyroiditis in the Same Three Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Ashley Schaffer ◽  
Vidya Puthenpura ◽  
Ian Marshall
Keyword(s):  
Case Report ◽  
Autoimmune Disease ◽  
Thyroid Gland ◽  
Hashimoto’S Thyroiditis ◽  
Monozygotic Twins ◽  
The Other ◽  
Initial Presentation ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
The Relationship

Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are the 2 most common autoimmune disease processes affecting the thyroid gland. The relationship between the two is complex and not clearly understood. It has been theorized that HT and GD are 2 separate disease processes due to unique genetic differences demonstrated by genome studies. On the other hand, based on occurrence of both HT and GD in monozygotic twins and within the same family, they have been regarded to represent 2 ends of the same spectrum. This case report describes 3 patients who presented with thyrotoxicosis due to both GD and HT. The initial presentation was thyrotoxicosis due to GD treated with antithyroid medication followed by temporary resolution. They all subsequently experienced recurrence of thyrotoxicosis in the form of Hashitoxicosis due to HT, and then eventually all developed thyrotoxicosis due to GD, requiring radioablation therapy.

GRAVES' DIEASE AND HASHIMOTO'S THYROIDITIS IN MONOZYGOUS TWINS

1973 ◽  
Vol 72 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Bruce S. Chertow ◽  
William J. Fidler ◽  
Bruce L. Fariss
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Monozygotic Twins ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Thyroglobulin Antibodies ◽  
Protein Binding Assay ◽  
Competitive Protein Binding Assay ◽  
Competitive Protein Binding ◽  
High Concentrations ◽  
Monozygous Twins

ABSTRACT Monozygous twins and their family were studied. One twin had Graves' disease and the other had Hashimoto's thyroiditis. Their mother had Hashimoto's thyroiditis and their maternal grandmother and maternal great aunt had hyperthyroidism. Thyroid biopsies were obtained in each of the twins and showed changes of Graves' disease and Hashimoto's thyroiditis, respectively. High concentrations of anti-thyroid microsomal and anti-thyroglobulin antibodies were present by competitive protein binding assay, but LATS was absent in the twins and their mother. The occurrence of Graves' disease and Hashimoto's thyroiditis in monozygotic twins supports the concept of a common genetic aetiologic factor in the basic pathogenesis of these two diseases; however, the expression of this factor is variable, acquired, and, at least in part, genetically independent.

Primary Non-Hodgkin's T-Cell Lymphoma of the Thyroid Gland Complicating Hashimoto's Thyroiditis: Case Report

Thyroid ◽  
2000 ◽  
Vol 10 (8) ◽  
pp. 717-720 ◽  
Author(s):  
Mehmet Haciyanli ◽  
Nazif Erkan ◽  
Kutsal Yorukoglu ◽  
Ozgul Sagol ◽  
Ömer Harmancioğlu
Keyword(s):  
Case Report ◽  
T Cell ◽  
Thyroid Gland ◽  
Hashimoto’S Thyroiditis ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Hashimoto's Thyroiditis

scholarly journals Association of Hashimoto’s Thyroiditis and Graves’ Disease: A Case Report and Review of the Literature

2021 ◽  
Vol 10 (10) ◽  
pp. 303-307
Author(s):  
Nafissatou Diagne ◽  
Maimouna Sow ◽  
Atoumane Faye ◽  
Awa Cheikh Ndao ◽  
Mouhamed Dieng ◽  
...  
Keyword(s):  
Case Report ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Review Of The Literature

Identification of apoptotic proteins in thyroid gland from patients with Graves' disease and Hashimoto's thyroiditis

Autoimmunity ◽  
2008 ◽  
Vol 41 (2) ◽  
pp. 163-173 ◽  
Author(s):  
A. Bossowski ◽  
B. Czarnocka ◽  
K. Bardadin ◽  
A. Stasiak-Barmuta ◽  
M. Urban ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Apoptotic Proteins

scholarly journals Graves’ disease and Hashimoto’s thyroiditis in monozygotic twins: case study as well as transcriptomic and immunohistological analysis of thyroid tissues

2006 ◽  
Vol 154 (1) ◽  
pp. 13-20 ◽  
Author(s):  
G Aust ◽  
K Krohn ◽  
N G Morgenthaler ◽  
S Schröder ◽  
A Schütz ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Hashimoto’S Thyroiditis ◽  
Thyroid Tissue ◽  
Monozygotic Twins ◽  
Hashimoto's Thyroiditis ◽  
Simultaneous Occurrence ◽  
Graves Disease ◽  
Autoimmune Thyroid ◽  
Extracellular Matrix Components ◽  
Lymphocytic Infiltrates

Objective: To report on the rare simultaneous occurrence of Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) in monozygotic twins. Design: We compared the pattern of thyroid tissue-derived cDNAs to gain insight into previous and ongoing immune destruction and reconstruction processes using microarrays. The results were confirmed by immunohistology and real-time PCR. Results: Destruction of thyroid tissue in HT reduced levels of thyrocyte-related cDNAs and cDNAs encoding extracellular matrix components, but increased levels of proteases involved in extracellular matrix degradation compared with GD. Lymphocytic infiltrates forming ectopic follicles replaced the thyroid tissue almost completely in HT. Thus, lymphocyte-related cDNA levels were higher in HT than in GD. The same was true for many chemokines and their receptors, which not only enable migration towards the thyroid but also maintain the lymphocytic infiltrate. HT also showed increased levels of cDNAs encoding molecules related to apoptosis than did GD. Surprisingly, the Th1- and Th2-specific cytokine profiles suggested for HT and GD respectively could not be confirmed. cDNAs encoding factors and receptors involved in angiogenesis were increased in GD compared with HT. Conclusions: Comparison of gene expression reflects the cellular differences between the two types of autoimmune thyroid disease in twins with identical genetic and similar environmental background.

scholarly journals Endoscopic orbital decompression in Graves ophthalmopathy - Case report

2018 ◽  
Vol 8 (30) ◽  
pp. 121-124
Author(s):  
Vlad A. Budu ◽  
Tatiana Decuseara ◽  
Ioan Bulescu ◽  
Andrei Panfiloiu ◽  
Lavinia Georgiana Sava ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Autoimmune Disease ◽  
Thyroid Gland ◽  
Surgical Outcome ◽  
Graves Disease ◽  
Orbital Decompression ◽  
Graves Ophthalmopathy

Abstract Graves ophthalmopathy, an autoimmune disease, associated with hypermetabolism, enlargement of the thyroid gland and exophthalmia are the most frequent expressions of Graves’ disease, which often require surgical treatment. We present the case of a 41-year-old male with severe Graves ophthalmopathy for which we performed an endoscopic orbital decompression with good surgical outcome, the patient being discharged after 48 hours.

scholarly journals The Place of Surgery in Thyroidal Autoimmune Conditions

2021 ◽  
pp. 1-2
Author(s):  
Constantinos Avgoustou ◽  
Constantinos Avgoustou ◽  
Avgoustou Eirini
Keyword(s):  
Thyroid Gland ◽  
Medical Treatment ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Autoimmune Conditions

The two most common autoimmune conditions of the thyroid gland, Hashimoto's thyroiditis (HT) and Graves' disease (GD) are the frequent causes of inflammation of the thyroid, with major consequences in the function of the organ, which is substantially disturbed in the prolonged disease. Although medical treatment is always the primary and mostly the unique consideration for the treatment of both diseases, there are certain indications that make surgery inevitable and essential to their management.

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