scholarly journals Randomized, Double-Blinded, Double-Dummy, Active-Controlled, and Multiple-Dose Clinical Study Comparing the Efficacy and Safety of Mulberry Twig (Ramulus Mori, Sangzhi) Alkaloid Tablet and Acarbose in Individuals with Type 2 Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Mengyi Li ◽  
Xuemin Huang ◽  
Hui Ye ◽  
Yao Chen ◽  
Jing Yu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Efficacy And Safety ◽  
Postprandial Plasma Glucose ◽  
Glucose Levels ◽  
Fasting Plasma ◽  
Significant Difference

Aims. To evaluate the efficacy and safety of mulberry twig alkaloid (SZ-A) tablet compared with acarbose in patients with type 2 diabetes.Methods. This clinical trial enrolled 38 patients who were randomized into two groups (SZ-A: 23; acarbose: 15) and were treated for 24 weeks. Patients and clinical trial staffs were masked to treatment assignment throughout the study. The primary outcome measures were glycated hemoglobin (HbA1c) and 1-hour and 2-hour postprandial and fasting plasma glucose levels from baseline to the end of treatment. Analysis included all patients who completed this study.Results. By the end of this study, HbA1c level in SZ-A group was decreased from baseline significantly (P<0.001). No significant difference was found when compared with acarbose group (P=0.652). Similarly, 1-hour and 2-hour postprandial plasma glucose levels in SZ-A group were decreased from baseline statistically (P<0.05), without any significant differences compared with acarbose group (P=0.748and 0.558, resp.). The fasting plasma glucose levels were not significantly changed in both groups. One of 23 patients in SZ-A group (4.76%) and 5 of 15 patients in acarbose group (33.33%) suffered from gastrointestinal adverse events.Conclusions. Compared with acarbose, SZ-A tablet was effective and safe in glycemic control in patients with type 2 diabetes.

scholarly journals A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

2008 ◽  
Vol 41 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Nabila Bouatia-Naji ◽  
Amélie Bonnefond ◽  
Christine Cavalcanti-Proença ◽  
Thomas Sparsø ◽  
Johan Holmkvist ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Diabetes Risk ◽  
Glucose Levels ◽  
Fasting Plasma

scholarly journals A STUDY OF PLASMA GLUCOSE AND SERUM CERULOPLASMIN IN TYPE-2 DIABETES MELLITUS (T2DM) AT A TERTIARY CARE HOSPITAL

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Mukul Sharma ◽  
Kapil Bhatia ◽  
Pratibha Misra ◽  
Sibin MK ◽  
Vivek N Ambade ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Care Hospital ◽  
Serum Ceruloplasmin ◽  
Glucose Levels ◽  
Fasting Plasma

Introduction: Diabetes mellitus (DM) is a metabolic disorder occurring due to either defect in the secretion of insulin or defect in the action of insulin characterized by hyperglycemia. Hyperglycemia causes oxidative stress due to increased production of mitochondrial Reactive oxygen species (ROS) in T2DM. Ceruloplasmin (Cp) acts as an antioxidant through its ferroxidase activity. There is an association between the raised serum Cp levels and elevated plasma glucose levels in Type-2 Diabetes mellitus (T2DM) patients. Aim and objectives: The aim of this study is to evaluate the correlation between the fasting plasma glucose (FPG), 2hour plasma glucose (2hPG), and serum Cp level in T2DM patients as compared to non diabetics. Materials and methods: 165 cases of T2DM were recruited along with the 40 healthy age and sex matched controls. The blood samples were analyzed for serum Cp and FPG and 2hPG after 75-gram oral glucose. Results: The serum Cp levels of the patient group with T2DM were significantly higher than the control group (p = 0.000). There was a significant positive association between serum Cp level and 2hPG level of the patient population (r = 0.283, p = 0.000), but there was no significant correlation found between serum Cp levels and fasting plasma glucose levels in patients (r = 0.146, p =0.061). Similar findings were seen in the sub group analysis. Conclusion: Our study concludes a significant positive correlation between serum Cp and 2hPG levels in T2DM patients. Hence Cp levels may be considered as a part of the routine diagnostic panel to assess diabetes mellitus. Keywords: Serum Ceruloplasmin, Type-2 Diabetes Mellitus, Fasting plasma glucose, 2hour plasma glucose

scholarly journals Using GH-Method: Math-Physical Medicine to Investigate Different Contribution Margins of Fasting Plasma Glucose vs. Postprandial Plasma Glucose on HbA1C

2020 ◽  
Vol 3 (3) ◽  
Keyword(s):  
Type 2 Diabetes ◽  
Medical Research ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Physical Medicine ◽  
Postprandial Plasma Glucose ◽  
Fasting Plasma ◽  
Metabolic Conditions

This paper displays results of the contribution margin calculation of fasting plasma glucose (FPG) vs. postprandial plasma glucose (PPG) on HbA1C. The dataset is provided by the author, who uses his own type 2 diabetes metabolic conditions control, as a case study via the “math-physical medicine” approach of a nontraditional methodology in medical research.

Guesstimate Probable Partial Self-Recovery of Pancreatic Beta Cells Using Calculations of Annualized Glucose Data Using GH-Method: Math-Physical Medicine

2020 ◽  
pp. 1-4
Author(s):  
Gerald C. Hsu
Keyword(s):  
Type 2 Diabetes ◽  
Beta Cells ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Pancreatic Beta Cells ◽  
Physical Medicine ◽  
Postprandial Plasma Glucose ◽  
Fasting Plasma ◽  
Regeneration Capability

In this paper, the author describes his hypothesis on the probable partial self-recovery of some insulin regeneration capability of pancreatic beta cells on a Type 2 Diabetes (T2D) patient via his collected data of both Postprandial Plasma Glucose (PPG) and Fasting Plasma Glucose (FPG) during the period of 1/1/2014 to 11/23/2019.

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