scholarly journals Cytokine Reduction in the Setting of an ARDS-Associated Inflammatory Response with Multiple Organ Failure

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Karl Träger ◽  
Christian Schütz ◽  
Günther Fischer ◽  
Janpeter Schröder ◽  
Christian Skrabal ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Inflammatory Mediators ◽  
Clinical Status ◽  
Combined Treatment ◽  
Multiple Organ ◽  
Lung Mechanics ◽  
Anesthesia Induction ◽  
Indirect Measures ◽  
Respiratory Weaning

A 45-year-old male was admitted to our hospital with a small bowel obstruction due to torsion and was immediately scheduled for surgical intervention. At anesthesia induction, the patient aspirated and subsequently developed a severe SIRS with ARDS and multiple organ failure requiring the use of ECMO, CRRT, antibiotics, and low dose steroids. Due to a rapid deterioration in clinical status and a concurrent surge in inflammatory biomarkers, an extracorporeal cytokine adsorber (CytoSorb) was added to the CRRT blood circuit. The combined treatment resulted in a rapid and significant reduction in the levels of circulating inflammatory mediators. This decrease was paralleled by marked clinical stabilization of the patient including a significant improvement in hemodynamic stability and a reduced need for norepinephrine and improved respiratory function as measured by PaO2/FIO2, ventilator parameters, lung mechanics, and indirect measures of capillary leak syndrome. The patient could be discharged to a respiratory weaning unit where successful respiratory weaning could be achieved later on. We attribute the clinical improvement to the rapid control of the hyperinflammatory response and the reduction of inflammatory mediators using a combination of CytoSorb and these other therapies. CytoSorb treatment was safe and well tolerated, with no device-related adverse effects observed.

Multiple organ failure in human acute pancreatitis is associated with increased local and systemic inflammatory mediators

2000 ◽  
Vol 118 (4) ◽  
pp. A673
Author(s):  
Jens M. Mayer ◽  
Bettina Rau ◽  
Frank Gansauge ◽  
Hans G. Beger
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Inflammatory Mediators ◽  
Multiple Organ ◽  
Human Acute Pancreatitis

Release of anti-inflammatory mediators after major torso trauma correlates with the development of postinjury multiple organ failure

1999 ◽  
Vol 178 (6) ◽  
pp. 564-568 ◽  
Author(s):  
David A Partrick ◽  
Ernest E Moore ◽  
Frederick A Moore ◽  
Walter L Biffl ◽  
Carlton C Barnett
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Inflammatory Mediators ◽  
Multiple Organ ◽  
Anti Inflammatory ◽  
Torso Trauma

Multiple organ failure syndrome

1994 ◽  
Vol 14 (2) ◽  
pp. 25-26 ◽  
Author(s):  
E Reilly ◽  
CB Yucha
Keyword(s):  
Critical Care ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Metabolic Response ◽  
Clinical Status ◽  
Multiple Organ ◽  
Critical Care Nurses ◽  
Supportive Environment ◽  
Regulatory Aspects ◽  
Life Threatening

Although many new areas of research are directed at the regulatory aspects of the metabolic response, the prognosis of MOF remains poor. Critical care nurses, challenged to provide a supportive environment during this life-threatening syndrome, must understand its onset, clinical patterns, and prolonged support required by patients. Such knowledge will enable critical care nurses to detect subtle changes while monitoring clinical status, and facilitate timely interventions in order to decrease the morbidity and mortality associated with MOF.

Phospholipase A2 Regulates Critical Inflammatory Mediators of Multiple Organ Failure

1994 ◽  
Vol 56 (2) ◽  
pp. 199-205 ◽  
Author(s):  
Benjamin O. Anderson ◽  
Ernest E. Moore ◽  
Anirban Banerjee
Keyword(s):  
Phospholipase A2 ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Inflammatory Mediators ◽  
Multiple Organ

Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma

1995 ◽  
Vol 23 (3) ◽  
pp. 474-480 ◽  
Author(s):  
Rudi M. H. Roumen ◽  
Heinz Redl ◽  
Gunther Schlag ◽  
Gertrud Zilow ◽  
Wolfgang Sandtner ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Blunt Trauma ◽  
Inflammatory Mediators ◽  
Multiple Organ

Can Body Composition in Multiple Organ Failure be Favorably Influenced by Feeding?

Nutrition ◽  
1997 ◽  
Vol 13 (9) ◽  
pp. 79S-83S ◽  
Author(s):  
I Campbell
Keyword(s):  
Body Composition ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ

Clinical case of periostitis in pregnant women complicated by sepsis

2020 ◽  
pp. 61-63
Author(s):  
S. Sh. Kakvaeva ◽  
M. A. Magomedova ◽  
A. N. Dzhalilova
Keyword(s):  
Pregnant Woman ◽  
Multiple Organ Failure ◽  
Pregnant Women ◽  
Organ Failure ◽  
Clinical Case ◽  
Clinical Observation ◽  
Infectious Agent ◽  
Modern Medicine ◽  
Multiple Organ ◽  
Number Of Patients

One of the most serious problems of modern medicine is sepsis. The number of patients undergoing this complication is 20–30 million (WHO) annually and has no tendency to decrease. Sepsis is characterized by severe multiple organ failure due to a violation of the response of the macroorganism to an infectious agent. Moreover, it is dangerous with high mortality. Sepsis often develops in patients with immunodeficiency conditions, which primarily include pregnant women. The article presents a clinical observation of a case of periostitis in a pregnant woman complicated by a septic state.

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