scholarly journals Retroperitoneal Solitary Fibrous Tumor: A “Patternless” Tumor

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
D. Myoteri ◽  
D. Dellaportas ◽  
C. Nastos ◽  
I. Gioti ◽  
G. Gkiokas ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Spindle Cell ◽  
Pelvic Mass ◽  
Histopathological Diagnosis ◽  
Recurrence Rates ◽  
Rare Type ◽  
Case Presentation ◽  
Spindle Cells ◽  
Fibrous Tumor ◽  
Mesenteric Excision

Introduction. Solitary fibrous tumor is a rare type of mesenchymal, spindle-cell tumor reported mostly in the pleura. Retroperitoneal occurrence is rare and histopathological diagnosis is challenging. Case Presentation. A 55-year-old woman with nonspecific abdominal pain was found to have a retroperitoneal/pelvic mass adjacent to the upper rectum. The patient underwent surgical resection in clear margins of this pelvic tumor, entering the total mesenteric excision surgical plane. Final histopathology revealed a solitary fibrous tumor and the case is presented herein. Discussion. Solitary fibrous tumor in the retroperitoneum is rarely found in the literature and to the best of our knowledge less than a hundred cases are described so far. Histopathological diagnosis is mostly based on a “patternless pattern” on microscopic examination, which is a storiform arrangement of spindle cells combined with a “hemangiopericytoma-like appearance” and increased vascularity of the lesion. Surgery is the mainstay of treatment and recurrence rates are generally low.

Solitary Fibrous Tumor of the Anterior Mediastinum: A Rare Extrapleural Neoplasm

2007 ◽  
Vol 93 (5) ◽  
pp. 508-510 ◽  
Author(s):  
Brian R Gannon ◽  
Carolyn D O'Hara ◽  
Kenneth Reid ◽  
Phillip A Isotalo
Keyword(s):  
Solitary Fibrous Tumor ◽  
Mediastinal Mass ◽  
Spindle Cell ◽  
Sarcomatoid Carcinoma ◽  
Anterior Mediastinal Mass ◽  
Peripheral Nerve Sheath Tumors ◽  
Solitary Fibrous Tumors ◽  
Spindle Cells ◽  
Complete Surgical Excision ◽  
Fibrous Tumor

Solitary fibrous tumors are uncommon spindle cell neoplasms originally thought to be restricted to the pleura. We describe a 62-year-old woman who presented with stridor and an anterior mediastinal mass. At thoracotomy, a 10.5 × 6.5 × 5.5 cm, circumscribed, firm mediastinal mass demonstrated no direct cardiac or pulmonary involvement. The tumor consisted of spindle cells organized in a patternless pattern with collagenous stroma and hemangiopericytoma-like vessels. Spindle cells were immunoreactive for CD34, CD99, desmin, vimentin and bcl-2 protein and a diagnosis of mediastinal solitary fibrous tumor was confirmed. The differential diagnosis of mediastinal solitary fibrous tumors is extensive and includes spindle cell thymoma, sarcomatoid carcinoma, malignant mesothelioma, inflammatory myofibroblastic tumor, peripheral nerve sheath tumors and various sarcomas. Despite their rarity in the mediastinum, solitary fibrous tumors can be recognized by their classic patternless morphology and immunophenotypic pattern. Their accurate classification is important, as solitary fibrous tumors are intermediate (rarely metastasizing) neoplasms that require complete surgical excision and long-term clinical follow-up for optimum therapy.

scholarly journals Solitary Fibrous Tumor of the Kidney with Massive Retroperitoneal Recurrence. A Case Presentation

2012 ◽  
Vol 113 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Stavros Sfoungaristos ◽  
M. Papatheodorou ◽  
A. Kavouras ◽  
P. Perimenis
Keyword(s):  
Solitary Fibrous Tumor ◽  
Tumor Recurrence ◽  
Spindle Cell ◽  
Surgical Excision ◽  
Imaging Findings ◽  
Case Presentation ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Fibrous Tumor ◽  
Disease Free

Solitary fibrous tumor is an unusual spindle cell neoplasm that usually occurs in the pleura but has also been described in other sites. Renal presentation is rare and only 38 cases of SFT of the kidney have been described until now. Up to 90% of the tumors have benign characteristics. Local retroperitoneal recurrence is extremely rare. We report a case of a large malignant solitary fibrous tumor recurrence after the surgical excision of the primary tumor. Histological examination of the specimen confirmed the diagnosis by revealing highly positive reaction of the neoplasmatic cells for vimentin, CD34, bcl-2 and moderately positive for actin. The rate of Ki67 lied between 2–7%. No adjuvant therapy was given to the patient and he is disease-free with no imaging findings of recurrence or metastasis 9 months after the re-operation.

scholarly journals Solitary Fibrous Tumor of the Spinal Nerve Rootlet: Report of a Case Mimicking Schwannoma

2004 ◽  
Vol 128 (3) ◽  
pp. 335-337 ◽  
Author(s):  
Simonetta Piana ◽  
Innocenza Putrino ◽  
Alberto Cavazza ◽  
Evandro Nigrisoli
Keyword(s):  
Solitary Fibrous Tumor ◽  
Epithelial Membrane Antigen ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Spinal Nerve ◽  
Lumbar Pain ◽  
Spindle Cells ◽  
Collagenous Stroma ◽  
Fibrous Tumor

Abstract We report a case of solitary fibrous tumor involving the spinal nerve root at the L1-L2 level in a 67-year-old man. The patient presented with lumbar pain and weakness in his right lower extremity. Histologically, the tumor was composed of a proliferation of monomorphous spindle cells in an abundant collagenous stroma; neither necrosis nor mitoses were evident. These cells were strongly immunoreactive with CD34, Bcl-2, CD99, and vimentin, but were negative with S100 protein, smooth muscle actin, and epithelial membrane antigen. Such an immunohistochemical profile was consistent with a solitary fibrous tumor of the spinal nerve rootlet and ruled out the main differential diagnoses, schwannoma and meningioma. The present case suggests that solitary fibrous tumor should be considered in differentiating spindle cell lesions of the spinal cord and nerve rootlet.

A Rare Case of Dedifferentiated Solitary Fibrous Tumor

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S42-S42
Author(s):  
A P Kanteti ◽  
E Martinez Duarte
Keyword(s):  
Solitary Fibrous Tumor ◽  
Spindle Cell ◽  
Clinical History ◽  
Low Grade ◽  
High Grade ◽  
Epithelioid Cells ◽  
Spindle Cells ◽  
Mesenchymal Neoplasm ◽  
Mitotic Figures ◽  
Fibrous Tumor

Abstract Casestudy: Dedifferentiated solitary fibrous tumor is a rare malignant subtype of the common benign mesenchymal neoplasm with fibroblastic differentiation known as solitary fibrous tumor (SFT). These account for less than 2% of all soft masses; and about 20% of SFTs turn aggressive. They feature bland spindle cells creating a classic “pattern-less pattern” in collagenous stroma with prominent staghorn vessels. They can dedifferentiate into a biphasic tumor with low grade areas that are spindle cell rich and high-grade areas with epithelioid cells, mitotic figures and necrosis. Here we present an 84-year-old female who came from an outside institution for a pathology review. The patient’s clinical history was lacking and biopsies from the right lower and middle lobes of the lung, azygous and hilar lymph nodes were investigated. The pathology revealed multiple areas with epithelioid cells that were pleomorphic and had high nuclear to cytoplasmic ratio. These areas also contained numerous mitotic figures, necrosis and giant cells; with lymphovascular space invasion. There was a clear demarcation between the epithelioid area and an area rich in spindle cells. The spindled areas revealed a fascicular architecture with intervening sclerotic stoma and prominent rounded and dilated blood vessels. Immunohistochemistry analysis of the epithelioid and spindle cell areas were positive for STAT6. Additional testing for CD34 was diffusely positive in the spindle cell component and only focally positive in the high-grade portion of the tumor. Ki-67stain was utilized to estimate the proliferative index which was up to 80 percent in the high-grade epithelioid component and about 15% in the spindle cell portion. These morphological and histochemical findings were consistent with the diagnosis of a dedifferentiated solitary fibrous tumor.

scholarly journals Solitary fibrous tumor of the greater omentum: case report and review of literature

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Karim M. Eltawil ◽  
Carly Whalen ◽  
Bryce Knapp
Keyword(s):  
Solitary Fibrous Tumor ◽  
Management Strategy ◽  
Abdominal Mass ◽  
Lower Abdominal Pain ◽  
Greater Omentum ◽  
Team Approach ◽  
Review Of Literature ◽  
Case Presentation ◽  
Multidisciplinary Team Approach ◽  
Fibrous Tumor

Abstract Background Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin occurring most often in the visceral pleura, however, it has been described in almost every anatomic location of the human body. While most SFTs have a benign behavior, they can potentially be locally aggressive and demonstrate a malignant behavior. Case presentation A 63 year-old male patient presented with lower abdominal pain and nausea and was noted on CT to have a large, heterogeneous lower abdominal mass with no evidence of metastatic disease. A surgical resection was performed and the mass appeared to be connected to the greater omentum with a vascular pedicle. It was not invading any intra-abdominal or pelvic organs. Pathology revealed an SFT of omental origin. The mitotic count was less than 4 per 10 high-power fields and all pathologic characteristics did not meet the criteria for a malignant SFT. Conclusions We report an extremely rare case of SFT originating from the greater omentum. A multidisciplinary team approach was followed to plan the patient’s management strategy.

scholarly journals Retroperitoneal fibrous tumor recurring as lung metastases after 10 years: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kozue Matsuishi ◽  
Kojiro Eto ◽  
Atsushi Morito ◽  
Hirokazu Hamasaki ◽  
Keisuke Morita ◽  
...  
Keyword(s):  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Distant Metastasis ◽  
Curative Resection ◽  
Lung Metastases ◽  
Lung Resection ◽  
Left Lung ◽  
Metastatic Lesion ◽  
Case Presentation ◽  
Fibrous Tumor

Abstract Background Solitary fibrous tumor (SFT) is a relatively rare mesenchymal tumor that mainly affects adults. Its prognosis is good after curative resection, but distant recurrences after 10 years or longer have been reported. Recurrent SFT usually arises as a local lesion; distant metastasis is rarely reported. Here, we report lung metastases that recurred a decade after excising a retroperitoneal primary SFT. Case presentation A 44-year-old woman had an SFT resected from her right retroperitoneum at our hospital. Ten years later, at age 54, she underwent a lung resection after CT showed three suspected metastases in her left lung. All three were histologically diagnosed as lung metastases from the retroperitoneal SFT. However, whereas the primary SFT had 1–2 mitotic cells/10 high power fields (HPF), the metastatic lesion increased malignancy, at 50/10 HPF. Conclusion Patients who have had resected SFTs should be carefully followed up, as malignancy may change in distant metastasis, as in this case.

Solitary Fibrous Tumor of the Prostate

2001 ◽  
Vol 125 (2) ◽  
pp. 274-277
Author(s):  
Michael R. Pins ◽  
Steven C. Campbell ◽  
William B. Laskin ◽  
Karen Steinbronn ◽  
Daniel P. Dalton
Keyword(s):  
Mitotic Activity ◽  
Solitary Fibrous Tumor ◽  
Growth Pattern ◽  
Spindle Cell ◽  
Cytologic Atypia ◽  
Diffuse Growth ◽  
High Mitotic Activity ◽  
Spindle Cell Tumors ◽  
Fibrous Tumor

Abstract We report 2 cases of solitary fibrous tumor of the prostate. Histologically, both tumors demonstrated a multipatterned architecture with varying degrees of collagenization and hemangiopericytoma-like foci, and both were composed of CD34-immunopositive spindled cells that insinuated themselves between strips of collagen. The tumor in case 1 was well circumscribed and showed minimal mitotic activity or pleomorphism, whereas the tumor in case 2 was more cellular, less collagenous, had a more diffuse growth pattern, and exhibited cytologic atypia and high mitotic activity. Prostatic solitary fibrous tumor must be distinguished from other spindle cell tumors reported to occur in the prostate. To our knowledge, these cases represent only the fifth and sixth reported cases of prostatic solitary fibrous tumor.

scholarly journals Intrapulmonary Solitary Fibrous Tumor of the Lung: A Rare Case Presentation

2016 ◽  
Vol 2 (2) ◽  
pp. 42-44
Author(s):  
S Parinita ◽  
KN Mohan Rao ◽  
Vivek LNU
Keyword(s):  
Solitary Fibrous Tumor ◽  
Rare Case ◽  
Pleural Cavity ◽  
Visceral Pleura ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Fibrous Tumor

ABSTRACT Localized fibrous tumors of the lung arise from the visceral pleura and are pedunculated. They also project into the pleural cavity. The tumor with an entirely pulmonary location is extremely rare. We present here a rare case of intrapulmonary localized fibrous tumor with review of the literature. How to cite this article Parinita S, Rao KNM, Vivek. Intrapulmonary Solitary Fibrous Tumor of the Lung: A Rare Case Presentation. J Med Sci 2016;2(2):42-44.

scholarly journals Endometrioid adenocarcinoma of the rectovaginal septum with invasion of the rectum: a case report and review of literature

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Hua Yang ◽  
Jiao-jiao Gu ◽  
Yue Qi ◽  
Wei Zhao ◽  
Xin-lu Wang
Keyword(s):  
Lower Abdominal Pain ◽  
Pelvic Mass ◽  
Preoperative Imaging ◽  
Histopathological Diagnosis ◽  
Endometrioid Adenocarcinoma ◽  
Rectovaginal Septum ◽  
Case Presentation ◽  
Additional Chemotherapy ◽  
Good Treatment Response ◽  
Gynecological Tumor

Abstract Background Malignant transformation of endometriosis in the rectovaginal septum is rare and usually misdiagnosed as a colorectal or gynecological tumor. We report a rare case of primary endometrioid adenocarcinoma of the rectovaginal septum with invasion of the rectum. Case presentation A 57-year-old overweight woman presented with vaginal bleeding and self-reported left lower abdominal pain during the previous 2 weeks. Preoperative imaging showed a large pelvic mass with invasion of the rectum, suggestive of a gynecologic malignancy. Multiple endoscopic biopsies and immunohistochemical analyses of specimens was performed. The patient received joint gynecological-surgical laparotomy, and there were no intra- or postoperative complications. The histopathological diagnosis was rectovaginal endometrioid adenocarcinoma with rectum infiltration. The patient received adjuvant chemotherapy and achieved good treatment response, with no early complications. At 12 months after surgery, there was no evidence of recurrence. Conclusions A high index of clinical suspicion is required for the diagnosis of endometrioid adenocarcinoma in the rectovaginal septum. Surgery combined with additional chemotherapy or radiotherapy seems to be a standard treatment, and hormonal therapy is optional. The efficacies of other therapies, including targeted medication and immunotherapy, are unknown.

Solitary Fibrous Tumor of the Parapharyngeal Space: A Case Report and Review of the Literature

1996 ◽  
Vol 75 (10) ◽  
pp. 681-684 ◽  
Author(s):  
Kunal Gangopadhyay ◽  
Khalid Taibah ◽  
M. Babu Manohar ◽  
Hala Kfoury
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Solitary Fibrous Tumor ◽  
Spindle Cell ◽  
Parapharyngeal Space ◽  
English Literature ◽  
Review Of The Literature ◽  
Solitary Fibrous Tumors ◽  
Rare Location ◽  
Fibrous Tumor

Solitary fibrous tumors are uncommon spindle cell neoplasms generally associated with serosal surfaces, especially the pleura. Recently, these tumors have been documented in a number of extrapleural sites including the head and neck. So far only two cases of parapharyngeal solitary fibrous tumor have been reported in the English literature. Rare location of an uncommon lesion often gives rise to difficulty in diagnosis or to misdiagnosis. In both the previously reported cases, as well as in our case, the diagnosis of solitary fibrous tumor was not made until the excised tumor was subjected to histopathology and immunohistochemistry.

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