Positive Correlation between IP-10 and IFN-γLevels in Rhesus Monkeys(Macaca mulatta)with Either Naturally Acquired or Experimental Infection ofMycobacterium tuberculosis

Numerous studies identify that IP-10 and IFN-γare involved in leucocyte migration and activation and regarded as promising surrogate biomarkers in human and bovine tuberculosis infection, but there is lack of evidence for IP-10 in nonhuman primates. In this study, we directly determined IP-10 and IFN-γlevels in plasma from 30 healthy monkeys, 30 monkeys with naturally acquired tuberculosis, 4 monkeys experimentally infected with tuberculosis, and PPD stimulated whole blood of 14 monkeys with naturally acquired tuberculosis by ELISA. Higher plasma levels of IP-10 and IFN-γwere observed in natural tuberculosis monkeys than in healthy controls. The dynamic changes of plasma IP-10 and IFN-γin experimental infections showed consistent representation of a transient increase during the infection period. After PPD stimulation, release of IP-10 and IFN-γis significantly induced in natural tuberculosis monkeys, but the stimulation index of IP-10 was significantly lower than IFN-γ. Further analysis showed that positive correlation between IP-10 and IFN-γexisted in healthy and tuberculosis monkeys. Our findings support plasma IP-10 and IFN-γas biomarkers for monitoring ongoing inflammation of nonhuman primate tuberculosis, and IFN-γis a more valuable diagnostic biomarker.

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Diabetic Nephropathy in Spontaneously Type 2 Diabetic Nonhuman Primates (Rhesus Monkeys Macaca mulatta ): Comparator Validation of Angiotensin Receptor Blocker Valsartan

The FASEB Journal ◽

10.1096/fasebj.2020.34.s1.07592 ◽

2020 ◽

Vol 34 (S1) ◽

pp. 1-1

Author(s):

Barbara Caleen Hansen ◽

Zunyuan Yang ◽

Yinan Liang ◽

Zunwei Yao ◽

Licai Zeng ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Macaca Mulatta ◽

Rhesus Monkeys ◽

Angiotensin Receptor Blocker ◽

Nonhuman Primates ◽

Receptor Blocker ◽

Angiotensin Receptor ◽

Type 2 Diabetic

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Oestradiol and somatomedin-C influence body weight patterns in premenarchial rhesus monkeys housed outdoors

Journal of Endocrinology ◽

10.1677/joe.0.1020311 ◽

1984 ◽

Vol 102 (3) ◽

pp. 311-317 ◽

Cited By ~ 7

Author(s):

M. E. Wilson ◽

S. M. Schwartz ◽

M. L. Walker ◽

T. P. Gordon

Keyword(s):

Body Weight ◽

Macaca Mulatta ◽

Rhesus Monkeys ◽

Serum Insulin ◽

Dynamic Changes ◽

Somatomedin C ◽

Gh Secretion ◽

Accelerated Growth ◽

Gonadal Status ◽

Serum Gh

ABSTRACT The influence of gonadal status on the pattern of changes in body weight was examined in three groups of outdoor-housed premenarchial rhesus monkeys (Macaca mulatta) from 1 to 2 years of age. Gonadally intact (n=8) and ovariectomized oestradiol-treated females (n=5) gained significantly more weight than ovariectomized untreated females (n=5). The overall larger weight gains for the intact and ovariectomized oestradiol-treated groups were associated with significantly higher fasting levels of serum insulin. All subjects exhibited two periods of significant weight gain from 12 to 16 months of age between May and September and from 21 to 24 months of age between February and May. Serum GH and somatomedin-C levels were also raised during these periods of accelerated growth. Although the pattern of serum GH was similar among groups, serum somatomedin-C levels were significantly higher in both intact and ovariectomized oestradiol-treated subjects from 21 to 24 months of age, suggesting physiological levels of oestradiol may facilitate somatomedin-C production during periods of increased GH secretion. Thus, absolute changes in body weight in outdoor-housed premenarchial rhesus monkeys are influenced by gonadal status, possibly mediated through increases in serum insulin. Furthermore, dynamic changes in body weight occur during prepubertal development, with the largest increments associated with increased somatomedin-C levels at specific ages synchronized with natural changes in the environment. J. Endocr. (1984) 102, 311–317

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