Aging and immunity in nonhuman primates: I. Effects of age and gender on cellular immune function in rhesus monkeys (Macaca mulatta)

1988 ◽  
Vol 15 (2) ◽  
pp. 181-188 ◽  
Author(s):  
William B. Ershler ◽  
Christopher L. Coe ◽  
Stefan Gravenstein ◽  
Kevin T. Schultz ◽  
Roger G. Klopp ◽  
...  
Keyword(s):  
Immune Function ◽  
Macaca Mulatta ◽  
Rhesus Monkeys ◽  
Nonhuman Primates ◽  
Age And Gender ◽  
Cellular Immune Function ◽  
And Gender ◽  
Cellular Immune

scholarly journals Drusenoid maculopathy in rhesus monkeys (Macaca mulatta): effects of age and gender

2008 ◽  
Vol 246 (10) ◽  
pp. 1395-1402 ◽  
Author(s):  
Peter Gouras ◽  
Lena Ivert ◽  
Noelle Landauer ◽  
Julie A. Mattison ◽  
Donald K. Ingram ◽  
...  
Keyword(s):  
Macaca Mulatta ◽  
Rhesus Monkeys ◽  
Age And Gender ◽  
And Gender

scholarly journals Marital distress prospectively predicts poorer cellular immune function

2013 ◽  
Vol 38 (11) ◽  
pp. 2713-2719 ◽  
Author(s):  
Lisa M. Jaremka ◽  
Ronald Glaser ◽  
William B. Malarkey ◽  
Janice K. Kiecolt-Glaser
Keyword(s):  
Immune Function ◽  
Marital Distress ◽  
Cellular Immune Function ◽  
Cellular Immune

scholarly journals Immunologic and clinical effects of repeated blood exchange in familial erythrophagocytic lymphohistiocytosis

Blood ◽  
1982 ◽  
Vol 60 (4) ◽  
pp. 814-821 ◽  
Author(s):  
S Ladisch ◽  
W Ho ◽  
D Matheson ◽  
R Pilkington ◽  
G Hartman
Keyword(s):  
Immune Function ◽  
Inhibitory Activity ◽  
Clinical Effects ◽  
Cellular Immune Function ◽  
Susceptibility To Infection ◽  
Blood Exchange ◽  
Cellular Immunodeficiency ◽  
Cellular Immune ◽  
Immune Defects

Depressed cellular immune function and increased susceptibility to infection characterize familial erythrophagocytic lymphohistiocytosis (FEL), a usually fatal autosomal recessive disease. One component of the immunodeficiency is plasma-mediated inhibition of lymphocyte proliferation. We have tested whether repeated plasma or blood exchange would decrease plasma inhibitory activity and improve cellular immune function in FEL. Following this treatment, reduction in plasma inhibitory activity, reversal of depressed antigen-specific lymphocyte proliferative responses and monocyte antibody-dependent cytotoxic function in vitro, and clinical improvement were complete in two and partial in one of three patients studied. Relapse, which was ultimately fatal, was associated with recurrence of the immune defects. These findings suggest that cellular immunodeficiency in FEL is acquired and possibly related to circulating immunosuppressive activity, the removal of which is associated with transient immunologic and clinical recovery.

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