Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients

Purpose. To evaluate clinically activated retinal astrocytes and Müller cells (ARAM) regarding retinal sensitivity and retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG). Methods. Central visual field (VF; i.e., retinal sensitivity) was measured with a custom-made macular pattern by microperimetry and correlated with the presence (ARAM+) or absence (ARAM−) of ARAM on red-free fundus photography and with the corresponding RNFL by optical coherence tomography (OCT). Results. In the eyes of POAG patients, ARAM+ had overall a significantly lower retinal sensitivity (ARAM+: 7.34 dB, ARAM−: 11.9 dB; p<0.001) and lower RNFL thickness in the inferior peripapillary quadrants compared to ARAM− (RNFL superior: ARAM+ 74.2 μm, ARAM− 77.5 μm; RNFL temporal: ARAM+ 46.8 μm, ARAM− 53.0 μm, p<0.001; and RNFL inferior: ARAM+ 63.2 μm, ARAM− 73.1 μm, p<0.001). Within the same eye, ARAM+ showed a lower retinal sensitivity compared to ARAM− ([ARAM− (11.13 dB)] − [ARAM+ (9.56 dB) = 1.57 dB; p=0.25). The proportion of ARAM+ per eye correlated strongly with reduced retinal light sensitivity (p=0.02), corresponding lower peripapillary RNFL thickness (p=0.02), and lower RNFL temporal quadrant thickness (p<0.01), but not with greater age (p=0.45). Conclusion. ARAM was more frequently identified in the eyes with a lower retinal sensitivity and peripapillary RNFL thickness and may be a clinical sign in the macula for an advanced stage of POAG.

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Relationship between optic nerve head topography and nerve fiber layer thickness with central corneal thickness in patients with primary open-angle glaucoma

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh191126066c ◽

2020 ◽

pp. 66-66

Author(s):

Natasa Civcic-Kalinic ◽

Miroslav Stamenkovic ◽

Nada Civcic ◽

Stefan Brunet

Keyword(s):

Central Corneal Thickness ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Corneal Thickness ◽

Area Ratio ◽

Open Angle ◽

Fiber Layer ◽

Rnfl Thickness ◽

Disc Area ◽

Thin Cornea

Introduction/Objective. In patients with primary open-angle glaucoma (POAG) we explored the relationship between optic nerve head (ONH) topography parameters and retinal nerve fiber layer (RNFL) thickness with central corneal thickness (CCT). Methods. This retrospective study included 97 patients (97 eyes) with primary open-angle glaucoma. Patients were divided into a thin CCT<540?m (45 eyes) and a thick CCT?540?m (52 eyes) group, using ultrasonic pachymeter. Topographic measurements of the ONH parameters and RNFL thickness was performed using optical coherence tomography (OCT). The outcomes were compared with the thin and thick CCT and correlated with the thin CCT of the subjects. Results. There were significantly lower mean intraocular pressure (IOP) (p<0.0001) and CCT (p<0.0001) in patients with thin CCT compared to patients with thick CCT. Statistically significant differences of ONH parameters were found in thin cornea group compared to thick cornea group in: cup/disc area ratio (p<0.03), vertical cup/disc ratio (p<0.01) and rim volume (p<0.01). Statistically significant differences of RNFL thickness were found in thin cornea group compared to thick cornea group in: average (p<0.001), superior (p<0.03), inferior (p<0.03) and nasal (p<0.01). Significant positive correlation was found between thin CCT and OCT parameters in: optic disc area (r=0.429, p=0.003), cup/disc area ratio (r=0.287, p=0.05), horizontal cup/disc ratio (r=0.472, p<0.001), vertical cup/disc ratio (r=0.578, p<0.001), average RNFL (r=0.796, p<0.001), superior RNFL (r=0.665, p<0.001), inferior RNFL (r=0.650, p<0.001), nasal RNFL (r=0.611, p<0.001) and temporal RNFL thickness (r=0.601, p<0.001). Conclusion. POAG patients with thin cornea will probably develop larger glaucoma changes than those with a thicker cornea. Ultrasonic pachymetry measurements of CCT and OCT analysis of ONH topography parameters and RNFL thickness provide significant information in early diagnosis and monitoring progression of POAG.

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Pengaruh Lamanya Pemberian Citicoline dalam Memperbaiki Retinal Nerve Fiber Layer (Rnfl) dan Lapang Pandangan pada Primary Open Angle Glaucoma (Poag)

Jurnal Kesehatan Andalas ◽

10.25077/jka.v3i1.28 ◽

2014 ◽

Vol 3 (1) ◽

Author(s):

Kemala Sayuti ◽

Harmen Harmen ◽

Hondrizal Hondrizal

Keyword(s):

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

Mean Sensitivity ◽

Retinal Nerve Fiber

AbstrakTujuan penelitian ini adalah untuk menilai pengaruh lamanya pemberian citicoline dalam memperbaiki kualitas RNFL dan lapang pandangan pada POAG. Penelitian ini dilakukan pada pasien POAG yang datang dari bulan September 2010 – Januari 2011 dengan tehnik consecutive sampling. Semua subjek penelitian yang sudah diskrining dilakukan pemeriksaan OCT dan perimetri segera sebelum pemberian citicoline, pemeriksaan ulangan dilakukan setelah 10 hari pertama, 10 hari kedua, dan 10 hari ketiga pemberian citicoline. Dari penelitian ini didapatkan perbaikan ketebalan RNFL dengan pemeriksaan OCT lebih banyak terjadi pada pemberian citicoline selama 10 hari III (45.7%) dibandingkan dengan pemberian 10 hari I (25,7%) dan 10 hari II (42,9%). Perbaikan mean sensitivity lapang pandangan dengan pemeriksaan perimetri lebih banyak terjadi pada pemberian citicoline selama 10 hari III (51,4%) dibandingkan dengan pemberian 10 hari I (32.4%) dan 10 hari II (37.2%). Lama pemberian citicoline sangat berpengaruh meningkatkan ketebalan RNFL dengan pemeriksaan OCT dan mean sensitivity lapang pandangan dengan pemeriksaan perimetri pada pasien POAG dan bermakna secara statistik dengan p=0.000 dan p=0.001Kata kunci: Primary Open Angle Glaucoma, Retinal Nerve Fiber Layer, CiticolineAbstractThe objective of this study was to assessing the influence of duration of citicoline administration in improve the quality of RNFL and visual field in POAG. The study was conducted in patients with POAG who take place in September 2010 - January 2011 with consecutive sampling technique. After screening examination, subjects underwent OCT examination and early perimetry after the administration of citicoline, re-examination were in first 10 days, second 10 days, and third 10 days. RNFL thickness by OCT examination were much more going in citicoline administered for the third 10 days (45.7%) compared with the provision of first 10 days (25.7%) and second 10 day (42.9%). Mean sensitivity improvements with visual field perimetry examination occurs more frequently in the administration of citicoline for the third 10 days (51.4%), compared with 10 days of first administration (32.4%) and second 10 days (37.2%). Length of citicoline administration is influencing of RNFL thickness in OCT examination and improvement of the mean sensitivity of perimetry examination in patients with POAG and statistically significant, each with p = 0.000 and p = 0.001.Keywords: Primary Open Angle Glaucoma, Retinal Nerve Fiber Layer, Citicoline

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Retinal nerve fiber layer thickness analysis in normal, ocular hypertensive, and primary open angle glaucoma: an optical coherence tomography study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20181287 ◽

2018 ◽

Vol 6 (4) ◽

pp. 1304

Author(s):

Dipak Patel ◽

Poonam Rana ◽

Siddharth Dua ◽

Roshni Patel

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Optical Coherence ◽

Open Angle ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Rnfl Thickness

Background: To correlate the findings of optical coherence tomography (OCT) evaluation of retinal nerve fiber layer (RNFL) thickness in primary open angle glaucoma, ocular hypertensive and normal eyes.Methods: A 34 consecutive normal, 26 consecutive ocular hypertensives and 40 consecutive glaucomatous eyes underwent a complete ophthalmic examination, including applanation tonometry, disc evaluation, gonioscopy and perimetry. Thickness of the RNFL around the optic disc was determined with 3.4 mm diameter-wide 3D 2000 TOPCON OCT. Average and segmental RNFL thickness values were compared among all groups.Results: Of the 100 eyes enrolled, the mean RNFL thickness was significantly less in glaucomatous eyes (83.165±15.938) than in normal’s (102.42±15.2) and ocular hypertensive’s (100.45±7.38). RNFL, average thicknesses in all four quadrants in POAG patients were significantly decreased compared with the OHT and the control groups.Conclusions: RNFL measurement with SD-OCT could provide important information for detection of early stages of glaucoma. (pre-perimetric glaucoma) as well as help in evaluating progression of glaucoma.

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Study of Retinal Nerve Fiber Layer Thickness by Optical Coherence Tomography in Primary Open Angle Glaucoma, Glaucoma Suspect and Normal Nepalese Population

Nepal Medical College Journal ◽

10.3126/nmcj.v22i3.32635 ◽

2020 ◽

Vol 22 (3) ◽

pp. 135-140

Author(s):

Srijana Thapa Godar ◽

KR Kaini

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

Retinal Nerve Fiber

The measurement of retinal nerve fiber layer thickness can help significantly in the early diagnosis of glaucoma and monitoring of its progression. The objective of this study was to compare the retinal nerve fiber layer (RNFL) thickness by optical coherence tomography in primary open angle glaucoma, glaucoma suspects and normal Nepalese population. This was a hospital based cross-sectional study conducted in the Ophthalmology Out Patient Department of Manipal Teaching Hospital, Pokhara. Total 100 numbers of subjects (40 primary open angle glaucoma, 30 glaucoma suspects and 30 normal people) were evaluated. Complete ophthalmological examinations including tonometry, gonioscopy, optical coherence tomography, perimetry were performed. Statistical analysis was carried out using Epi-info 7. The result showed that the average retinal nerve fiber layer (RNFL) thickness was 70.22±12.07μm in right eye and 69.42±11.53μm in left eye in primary open angle glaucoma (POAG), 88.87±10.39μm in right eye and 88.73±9.59μm in left eye in glaucoma suspects (GS) and 94.40±9.21μm in right eye and 94.73±6.76μm in left eye in normal group respectively. The mean RNFL thickness was statistically significant in all three comparison groups except in nasal quadrant. The mean RNFL thickness was statistically significant in two comparison groups except in GS-Normal (nasal and temporal quadrant), GS-POAG (left nasal quadrant) and Normal-POAG (left nasal quadrant). The study concluded that the RNFL thickness is lower in POAG as compared to glaucoma suspects and normal group in the Nepalese population.

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Diagnostic capability of different morphological parameters for primary open‐angle glaucoma in the Chinese population

BMC Ophthalmology ◽

10.1186/s12886-021-01906-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ruoshi Li ◽

Xia Wang ◽

Yahui Wei ◽

Yuan Fang ◽

Tian Tian ◽

...

Keyword(s):

Healthy Subjects ◽

Chinese Population ◽

Primary Open Angle Glaucoma ◽

Early Stage ◽

Open Angle Glaucoma ◽

Structural Parameters ◽

Open Angle ◽

Fiber Layer ◽

Diagnostic Capability ◽

Diagnostic Power

Abstract Background To assess the diagnostic capability of novel Bruch’s membrane opening (BMO)-based disc parameters, the BMO-minimum rim width (BMO-MRW) and the BMO-minimum rim area (BMO-MRA) in the Chinese population and compare them to the retinal nerve fiber layer (RNFL) from optical coherence tomography (OCT) and the rim area (RA) from the Heidelberg retinal tomograph-III (HRT-III). Methods In total, 200 eyes of 77 healthy and 123 primary open-angle glaucoma (POAG) subjects were included in this cross-sectional study. All participants underwent the visual field test and structural measurements by OCT and HRT-III. The areas under the receiver operating characteristic curves (AUCs) of different structural parameters were calculated to assess their diagnostic power and compared using the DeLong test. Results In populations with different characteristics, the BMO-MRW and BMO-MRA had better diagnostic power than the RA. In discriminating between all POAG subjects and healthy controls and between early-stage patients and controls, the global BMO-MRW had comparable AUCs with the RNFL, but the BMO-MRA had lower AUCs than the RNFL. In healthy subjects with macrodiscs, both the global and sectoral BMO-MRW were thinner than those in healthy subjects with normal disc size. The AUCs of BMO-MRA, BMO-MRW and RNFL in subjects with macrodiscs were comparable. Additionally, in the myopic population, the BMO-MRA and BMO-MRW had comparable AUCs with the RNFL. Conclusions The BMO-MRW had comparable diagnostic power with the RNFL, and compared with BMO-MRW, the BMO-MRA might have advantages in certain populations, such as macrodiscs. All OCT-derived parameters exceeded the RA in diagnostic capability.

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