scholarly journals Relationship between optic nerve head topography and nerve fiber layer thickness with central corneal thickness in patients with primary open-angle glaucoma

2020 ◽  
pp. 66-66
Author(s):  
Natasa Civcic-Kalinic ◽  
Miroslav Stamenkovic ◽  
Nada Civcic ◽  
Stefan Brunet
Keyword(s):  
Central Corneal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Area Ratio ◽  
Open Angle ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Disc Area ◽  
Thin Cornea

Introduction/Objective. In patients with primary open-angle glaucoma (POAG) we explored the relationship between optic nerve head (ONH) topography parameters and retinal nerve fiber layer (RNFL) thickness with central corneal thickness (CCT). Methods. This retrospective study included 97 patients (97 eyes) with primary open-angle glaucoma. Patients were divided into a thin CCT<540?m (45 eyes) and a thick CCT?540?m (52 eyes) group, using ultrasonic pachymeter. Topographic measurements of the ONH parameters and RNFL thickness was performed using optical coherence tomography (OCT). The outcomes were compared with the thin and thick CCT and correlated with the thin CCT of the subjects. Results. There were significantly lower mean intraocular pressure (IOP) (p<0.0001) and CCT (p<0.0001) in patients with thin CCT compared to patients with thick CCT. Statistically significant differences of ONH parameters were found in thin cornea group compared to thick cornea group in: cup/disc area ratio (p<0.03), vertical cup/disc ratio (p<0.01) and rim volume (p<0.01). Statistically significant differences of RNFL thickness were found in thin cornea group compared to thick cornea group in: average (p<0.001), superior (p<0.03), inferior (p<0.03) and nasal (p<0.01). Significant positive correlation was found between thin CCT and OCT parameters in: optic disc area (r=0.429, p=0.003), cup/disc area ratio (r=0.287, p=0.05), horizontal cup/disc ratio (r=0.472, p<0.001), vertical cup/disc ratio (r=0.578, p<0.001), average RNFL (r=0.796, p<0.001), superior RNFL (r=0.665, p<0.001), inferior RNFL (r=0.650, p<0.001), nasal RNFL (r=0.611, p<0.001) and temporal RNFL thickness (r=0.601, p<0.001). Conclusion. POAG patients with thin cornea will probably develop larger glaucoma changes than those with a thicker cornea. Ultrasonic pachymetry measurements of CCT and OCT analysis of ONH topography parameters and RNFL thickness provide significant information in early diagnosis and monitoring progression of POAG.

Clinical Profile of Myopic Patients as a Risk Factor for Primary Open Angle Glaucoma - A Prospective Observational Study in Gorakhpur, Uttar Pradesh

2021 ◽  
Vol 8 (33) ◽  
pp. 3084-3089
Author(s):  
Ram Kumar Jaiswal ◽  
Ramyash Singh Yadav ◽  
Mridula Ranjan ◽  
Dipti Wahi ◽  
Chiranji Rai
Keyword(s):  
Risk Factor ◽  
Intraocular Pressure ◽  
Observational Study ◽  
High Myopia ◽  
Central Corneal Thickness ◽  
Prospective Observational Study ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Open Angle

BACKGROUND Myopia is a complex trait including both genetic and environmental factors as well as gene-environment interactions. It has been recognized as a risk factor for development of glaucoma. Both Myopia and raised IOP are known to increase mechanical stress at optic nerve head leading to glaucomatous nerve damage. This study intends to evaluate the clinical profile of myopic subjects and its correlation with Primary open angle glaucoma (POAG). METHODS A prospective observational study done from November 2019 to December 2020 after taking proper informed consent and ethical clearance. 164 eyes of 96 patients studied were divided into three groups, Group 1: low myopia (< -3.00D), Group 2: moderate myopia (-3.00 D to -5.75 D), Group 3: high myopia (≥ -6.00 D). A complete ocular examination was performed. Intraocular pressure was measured using Goldmann applanation tonometer. Visual field analysis using Humphrey automated perimetry was done in patients with suspected primary open angle glaucoma (POAG). Angle parameters and central corneal thickness (CCT) were measured using anterior segment optical coherence tomography (AS-OCT). RESULTS 164 eyes of 96 Myopic subjects were studied with no dropout during study period. Mean age was 46.05 yr. (range: 25-75 yr.). The refraction ranged from -0.50 DS to -17.00 DS. There was no statistically significant difference between Intraocular pressure (IOP), Central corneal thickness (CCT), corrected IOP and Nasal and Temporal Trabecular-iris Angle (TIA) between male and female of same age group. Mean IOP and mean CCT were found to vary significantly with age and with higher degree of myopia. Corrected IOP, Nasal and Temporal TIA increase significantly with higher degree of myopia. Cup-disc ratio (CDR) was found to be significantly higher in patients with moderate to high degree of Myopia. CONCLUSIONS Myopia is an important risk factor for development of primary open angle glaucoma, with its incidence increasing in patients with moderate to high myopia. KEYWORDS Myopia, Primary Open Angle Glaucoma, Intraocular Pressure, Central Corneal Thickness, Trabecular Iris Angle

scholarly journals Adjusting Intraocular Pressure for Central Corneal Thickness Does Not Improve Prediction Models for Primary Open-Angle Glaucoma

Ophthalmology ◽  
2012 ◽  
Vol 119 (3) ◽  
pp. 437-442 ◽  
Author(s):  
James D. Brandt ◽  
Mae O. Gordon ◽  
Feng Gao ◽  
Julia A. Beiser ◽  
J. Phillip Miller ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Central Corneal Thickness ◽  
Prediction Models ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Open Angle

scholarly journals Factors Related to Superior and Inferior Hemifield Defects in Primary Open-Angle Glaucoma

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Remi Takeuchi ◽  
Nobuko Enomoto ◽  
Kyoko Ishida ◽  
Ayako Anraku ◽  
Goji Tomita
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Defect Group ◽  
Ganglion Cell Complex ◽  
Open Angle ◽  
Contributing Factors ◽  
Fiber Layer ◽  
Defect Groups ◽  
Disc Area ◽  
History Of

Purpose. We aimed to investigate factors related to superior and inferior hemifield defects in primary open-angle glaucoma (POAG). Methods. Sixty-seven subjects with newly diagnosed, untreated POAG underwent optical coherence tomography (OCT) of the disc area, macular ganglion cell complex (mGCC), and circumpapillary retinal nerve fiber layer (cpRNFL) thickness within 6 months of the visual field (VF) test. Based on the VF and OCT results, 40 subjects had a superior and 27 an inferior hemifield defect. Clinical data including visual acuity, refractive error, disc hemorrhage, VF indexes, and medical history were recorded. Results. Average mGCC thickness corresponding to the defective hemifields was thinner in the superior VF defect group than in the inferior VF defect group (P=0.003). Average total deviation (TD) was comparable between the two groups. However, the superior VF defect group had a higher prevalence of defects (P=0.001) and lower TD (P=0.002) within central 5 degrees of VF than the inferior VF defect group. In multivariate regression analyses, the temporal-lower and inferior-temporal cpRNFL thicknesses were significant contributing factors to the inferior mGCC thickness in the superior VF defect group. In the inferior VF defect group, the disc area, family history of glaucoma, and temporal-upper cpRNFL thickness contributed to the superior mGCC thickness. Conclusion. The inferior mGCC thickness corresponding to the superior hemifield defect group was significantly thinner than the superior mGCC thickness corresponding to the inferior hemifield defect group. The factors related to the reduction of the corresponding mGCC thickness may differ between superior VF defect and inferior VF defect groups.

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